ABCC13

ABCC13
Identifiers
Aliases	ABCC13 , C21orf73, PRED6, ABCC13P, ATP binding cassette subfamily C member 13 (pseudogene)
External IDs	OMIM: 608835; GeneCards: ABCC13; OMA:ABCC13 - orthologs
Gene location (Human) Chr. Chromosome 21 (human) [1] Band 21q11.2 Start 14,236,206 bp [1] End 14,362,754 bp [1]
Orthologs Species Human Mouse Entrez 150000 n/a Ensembl ENSG00000243064 n/a UniProt n a n/a RefSeq (mRNA) NM_138726 NM_172024 NM_172025 NM_172026 n/a RefSeq (protein) n/a n/a Location (UCSC) Chr 21: 14.24 – 14.36 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Putative ATP-binding cassette transporter sub-family C member 13 is a protein that is not present in humans. In humans, ABCC13 is a pseudogene. ^[3]

Function

This gene is a member of the superfamily of genes encoding ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This family member is part of the MRP subfamily, which is involved in multi-drug resistance, but the human locus is now thought to be a pseudogene incapable of encoding a functional ABC protein. Alternative splicing results in multiple transcript variants; however, not all variants have been fully described. ^[3]

See also

• ATP-binding cassette transporter
• ABCC13+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

References

1. GRCh38: Ensembl release 89: ENSG00000243064 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "ABCC13 ATP binding cassette subfamily C member 13 (pseudogene) [ Homo sapiens (human) ]". National Center for Biotechnology Information . Retrieved 11 August 2019.

Further reading

• Dean M, Annilo T (2005). "Evolution of the ATP-binding cassette (ABC) transporter superfamily in vertebrates". Annual Review of Genomics and Human Genetics. 6: 123–42. doi:10.1146/annurev.genom.6.080604.162122. PMID   16124856.
• Annilo T, Dean M (Jul 2004). "Degeneration of an ATP-binding cassette transporter gene, ABCC13, in different mammalian lineages". Genomics. 84 (1): 34–46. doi:10.1016/j.ygeno.2004.02.010. PMID   15203202.
• Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance". Genome Biology. 5 (2): R8. doi: 10.1186/gb-2004-5-2-r8 . PMC   395752 . PMID   14759258.
• Brun ME, Ruault M, Ventura M, Roizès G, De Sario A (Jul 2003). "Juxtacentromeric region of human chromosome 21: a boundary between centromeric heterochromatin and euchromatic chromosome arms". Gene. 312: 41–50. doi:10.1016/S0378-1119(03)00530-4. PMID   12909339.
• Yabuuchi H, Takayanagi S, Yoshinaga K, Taniguchi N, Aburatani H, Ishikawa T (Dec 2002). "ABCC13, an unusual truncated ABC transporter, is highly expressed in fetal human liver". Biochemical and Biophysical Research Communications. 299 (3): 410–7. doi:10.1016/S0006-291X(02)02658-X. PMID   12445816.
• Gardiner K, Slavov D, Bechtel L, Davisson M (Jun 2002). "Annotation of human chromosome 21 for relevance to Down syndrome: gene structure and expression analysis". Genomics. 79 (6): 833–43. doi:10.1006/geno.2002.6782. PMID   12036298.
• Allikmets R, Gerrard B, Hutchinson A, Dean M (Oct 1996). "Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database". Human Molecular Genetics. 5 (10): 1649–55. doi: 10.1093/hmg/5.10.1649 . PMID   8894702.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.