ABCB9

ABCB9
Identifiers
Aliases	ABCB9 , EST122234, TAPL, ATP binding cassette subfamily B member 9
External IDs	OMIM: 605453 MGI: 1861729 HomoloGene: 10491 GeneCards: ABCB9
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12q24.31 Start 122,920,951 bp [1] End 122,981,649 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5|5 F Start 124,199,593 bp [2] End 124,233,861 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in superficial temporal artery sperm oocyte prefrontal cortex ventral tegmental area cardia subthalamic nucleus Brodmann area 9 cingulate gyrus nucleus accumbens Top expressed in superior frontal gyrus entorhinal cortex cerebellar cortex olfactory tubercle primary motor cortex medulla oblongata inferior colliculus islet of Langerhans spermatid secondary oocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding ATPase activity protein homodimerization activity transmembrane transporter activity ABC-type oligopeptide transporter activity ATP binding ABC-type peptide transporter activity ATPase-coupled transmembrane transporter activity protein binding peptide transmembrane transporter activity Cellular component integral component of membrane early endosome membrane integral component of endoplasmic reticulum membrane endoplasmic reticulum lysosome lysosomal membrane intracellular membrane-bounded organelle Biological process transmembrane transport peptide transport antigen processing and presentation of peptide antigen via MHC class I protein transport oligopeptide transmembrane transport transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23457 56325 Ensembl ENSG00000150967 ENSMUSG00000029408 UniProt Q9NP78 Q9JJ59 RefSeq (mRNA) NM_001243013 NM_001243014 NM_019624 NM_019625 NM_203444 NM_203445 NM_019875 RefSeq (protein) NP_001229942 NP_001229943 NP_062570 NP_062571 NP_982269 NP_063928 Location (UCSC) Chr 12: 122.92 – 122.98 Mb Chr 5: 124.2 – 124.23 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

ATP-binding cassette sub-family B member 9 is a protein that in humans is encoded by the ABCB9 gene. ^{[5] [6]}

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. The function of this half-transporter has not yet been determined; however, this protein may play a role in lysosomes. Alternative splicing of this gene results in distinct isoforms which are likely to have different substrate specifications. ^[6]

See also

• ATP-binding cassette transporter

References

1. GRCh38: Ensembl release 89: ENSG00000150967 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029408 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Allikmets R, Gerrard B, Hutchinson A, Dean M (Feb 1997). "Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database". Hum Mol Genet. 5 (10): 1649–55. doi: 10.1093/hmg/5.10.1649 . PMID   8894702.
6. "Entrez Gene: ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9".

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Zhang F, Zhang W, Liu L, et al. (2000). "Characterization of ABCB9, an ATP binding cassette protein associated with lysosomes". J. Biol. Chem. 275 (30): 23287–94. doi: 10.1074/jbc.M001819200 . PMID   10748049.
• Nagase T, Kikuno R, Ishikawa K, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi: 10.1093/dnares/7.2.143 . PMID   10819331.
• Kobayashi A, Kasano M, Maeda T, et al. (2000). "A half-type ABC transporter TAPL is highly conserved between rodent and man, and the human gene is not responsive to interferon-gamma in contrast to TAP1 and TAP2". J. Biochem. 128 (4): 711–8. doi:10.1093/oxfordjournals.jbchem.a022805. PMID   11011155.
• Saito S, Iida A, Sekine A, et al. (2002). "Three hundred twenty-six genetic variations in genes encoding nine members of ATP-binding cassette, subfamily B (ABCB/MDR/TAP), in the Japanese population". J. Hum. Genet. 47 (1): 38–50. doi: 10.1007/s10038-002-8653-6 . PMID   11829140.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Kobayashi A, Hori S, Suita N, Maeda M (2003). "Gene organization of human transporter associated with antigen processing-like (TAPL, ABCB9): analysis of alternative splicing variants and promoter activity". Biochem. Biophys. Res. Commun. 309 (4): 815–22. doi:10.1016/j.bbrc.2003.08.081. PMID   13679046.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Homma K, Kikuno RF, Nagase T, et al. (2004). "Alternative splice variants encoding unstable protein domains exist in the human brain". J. Mol. Biol. 343 (5): 1207–20. doi:10.1016/j.jmb.2004.09.028. PMID   15491607.
• Wolters JC, Abele R, Tampé R (2005). "Selective and ATP-dependent translocation of peptides by the homodimeric ATP binding cassette transporter TAP-like (ABCB9)". J. Biol. Chem. 280 (25): 23631–6. doi: 10.1074/jbc.M503231200 . PMID   15863492.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Ohashi-Kobayashi A, Ohashi K, Du WB, et al. (2006). "Examination of drug resistance activity of human TAP-like (ABCB9) expressed in yeast". Biochem. Biophys. Res. Commun. 343 (2): 597–601. doi:10.1016/j.bbrc.2006.03.002. PMID   16554024.

External links

• ABCB9+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Human ABCB9 genome location and ABCB9 gene details page in the UCSC Genome Browser .

This article incorporates text from the United States National Library of Medicine, which is in the public domain.