ABCC3

ABCC3
Identifiers
Aliases	ABCC3 , ABC31, EST90757, MLP2, MOAT-D, MRP3, cMOAT2, ATP binding cassette subfamily C member 3
External IDs	OMIM: 604323; MGI: 1923658; HomoloGene: 68364; GeneCards: ABCC3; OMA:ABCC3 - orthologs
Gene location (Mouse) Chr. Chromosome 11 (mouse) [1] Band 11|11 D Start 94,234,121 bp [1] End 94,283,823 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic ductal cell right adrenal gland left adrenal gland right lobe of liver body of pancreas gallbladder rectum duodenum body of stomach pylorus Top expressed in transitional epithelium of urinary bladder spermatid left lobe of liver Ileal epithelium gastric mucosa mucous cell of stomach spermatocyte epithelium of stomach stroma of bone marrow duodenum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ATPase-coupled transmembrane transporter activity nucleotide binding organic anion transmembrane transporter activity ATPase activity ATP binding ATPase-coupled inorganic anion transmembrane transporter activity ABC-type bile acid transporter activity ABC-type xenobiotic transporter activity transmembrane transporter activity Cellular component integral component of membrane plasma membrane membrane basolateral plasma membrane integral component of plasma membrane vacuolar membrane Biological process transmembrane transport bile acid and bile salt transport xenobiotic transmembrane transport xenobiotic transport canalicular bile acid transport organic anion transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8714 76408 Ensembl n/a ENSMUSG00000020865 UniProt O15438 B2RX12 RefSeq (mRNA) NM_001144070 NM_003786 NM_020037 NM_020038 NM_029600 NM_001363187 NM_001363189 RefSeq (protein) NP_001137542 NP_003777 NP_083876 NP_001350116 NP_001350118 Location (UCSC) n/a Chr 11: 94.23 – 94.28 Mb PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

Canalicular multispecific organic anion transporter 2 is a protein that in humans is encoded by the ABCC3 gene. ^{[4] [5] [6]}

Function

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. ^[6]

ABCC3 is induced as a hepatoprotective response to a variety of pathologic liver conditions. The constitutive androstane receptor, pregnane X receptor and nuclear factor (erythroid-derived 2)-like 2 (Nrf2) transcription factors are involved in mediating induction. A functional antioxidant response element in the 8th intron of the human ABCC3 gene appears responsible for Nrf2-mediated induction in response to oxidative stress. ^[7]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. ^{[§ 1]}

[[File:

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

[[

]]

|alt=Fluorouracil (5-FU) Activity edit]]

Fluorouracil (5-FU) Activity edit

1. The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601".

See also

• ATP-binding cassette transporter

References

1. GRCm38: Ensembl release 89: ENSMUSG00000020865 – Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Allikmets R, Gerrard B, Hutchinson A, Dean M (Feb 1997). "Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database". Hum Mol Genet. 5 (10): 1649–55. doi: 10.1093/hmg/5.10.1649 . PMID   8894702.
5. Belinsky MG, Bain LJ, Balsara BB, Testa JR, Kruh GD (Dec 1998). "Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT subfamily of transporter proteins". J Natl Cancer Inst. 90 (22): 1735–41. doi: 10.1093/jnci/90.22.1735 . PMID   9827529.
6. "Entrez Gene: ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3".
7. Canet MJ, Merrell MD, Harder BG, Maher JM, Wu T, Lickteig AJ, Jackson JP, Zhang DD, Yamamoto M, Cherrington NJ (2014-10-27). "Identification of a Functional Antioxidant Response Element within the Eighth Intron of the Human ABCC3 Gene". Drug Metabolism and Disposition. 43 (1): 93–99. doi:10.1124/dmd.114.060103. PMC   4279086 . PMID   25349122.

Further reading

• Kool M, de Haas M, Scheffer GL, Scheper RJ, van Eijk MJ, Juijn JA, Baas F, Borst P (1997). "Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines". Cancer Res. 57 (16): 3537–47. PMID   9270026.
• Kiuchi Y, Suzuki H, Hirohashi T, Tyson CA, Sugiyama Y (1998). "cDNA cloning and inducible expression of human multidrug resistance associated protein 3 (MRP3)". FEBS Lett. 433 (1–2): 149–52. doi: 10.1016/S0014-5793(98)00899-0 . PMID   9738950. S2CID   82754183.
• Uchiumi T, Hinoshita E, Haga S, Nakamura T, Tanaka T, Toh S, Furukawa M, Kawabe T, Wada M, Kagotani K, Okumura K, Kohno K, Akiyama S, Kuwano M (1998). "Isolation of a novel human canalicular multispecific organic anion transporter, cMOAT2/MRP3, and its expression in cisplatin-resistant cancer cells with decreased ATP-dependent drug transport". Biochem. Biophys. Res. Commun. 252 (1): 103–10. doi:10.1006/bbrc.1998.9546. PMID   9813153.
• Fromm MF, Leake B, Roden DM, Wilkinson GR, Kim RB (1999). "Human MRP3 transporter: identification of the 5'-flanking region, genomic organization and alternative splice variants". Biochim. Biophys. Acta. 1415 (2): 369–74. doi:10.1016/S0005-2736(98)00233-8. PMID   9889399.
• König J, Rost D, Cui Y, Keppler D (1999). "Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatocyte membrane". Hepatology. 29 (4): 1156–63. doi: 10.1002/hep.510290404 . PMID   10094960. S2CID   1465220.
• Cole SP (1999). "Re: Characterization of MOAT-C and MOAT-D, new members of the MRP/cMOAT subfamily of transporter proteins". J. Natl. Cancer Inst. 91 (10): 888–9. doi:10.1093/jnci/91.10.888. PMID   10340910.
• Kool M, van der Linden M, de Haas M, Scheffer GL, de Vree JM, Smith AJ, Jansen G, Peters GJ, Ponne N, Scheper RJ, Elferink RP, Baas F, Borst P (1999). "MRP3, an organic anion transporter able to transport anti-cancer drugs". Proc. Natl. Acad. Sci. U.S.A. 96 (12): 6914–9. Bibcode:1999PNAS...96.6914K. doi: 10.1073/pnas.96.12.6914 . PMC   22016 . PMID   10359813.
• Ortiz DF, Li S, Iyer R, Zhang X, Novikoff P, Arias IM (1999). "MRP3, a new ATP-binding cassette protein localized to the canalicular domain of the hepatocyte". Am. J. Physiol. 276 (6 Pt 1): G1493–500. doi: 10.1152/ajpgi.1999.276.6.G1493 . PMID   10362653.
• Takada T, Suzuki H, Sugiyama Y (2000). "Characterization of 5'-flanking region of human MRP3". Biochem. Biophys. Res. Commun. 270 (3): 728–32. doi:10.1006/bbrc.2000.2507. PMID   10772892.
• Nies AT, König J, Pfannschmidt M, Klar E, Hofmann WJ, Keppler D (2002). "Expression of the multidrug resistance proteins MRP2 and MRP3 in human hepatocellular carcinoma". Int. J. Cancer. 94 (4): 492–9. doi: 10.1002/ijc.1498 . PMID   11745434.
• Tatebe S, Sinicrope FA, Kuo MT (2002). "Induction of multidrug resistance proteins MRP1 and MRP3 and gamma-glutamylcysteine synthetase gene expression by nonsteroidal anti-inflammatory drugs in human colon cancer cells". Biochem. Biophys. Res. Commun. 290 (5): 1427–33. doi:10.1006/bbrc.2002.6367. PMID   11820781.
• Scheffer GL, Kool M, de Haas M, de Vree JM, Pijnenborg AC, Bosman DK, Elferink RP, van der Valk P, Borst P, Scheper RJ (2002). "Tissue distribution and induction of human multidrug resistant protein 3". Lab. Invest. 82 (2): 193–201. doi: 10.1038/labinvest.3780411 . PMID   11850532.
• Zelcer N, Saeki T, Bot I, Kuil A, Borst P (2003). "Transport of bile acids in multidrug-resistance-protein 3-overexpressing cells co-transfected with the ileal Na+-dependent bile-acid transporter". Biochem. J. 369 (Pt 1): 23–30. doi:10.1042/BJ20021081. PMC   1223054 . PMID   12220224.
• Hooijberg JH, Peters GJ, Assaraf YG, Kathmann I, Priest DG, Bunni MA, Veerman AJ, Scheffer GL, Kaspers GJ, Jansen G (2003). "The role of multidrug resistance proteins MRP1, MRP2 and MRP3 in cellular folate homeostasis". Biochem. Pharmacol. 65 (5): 765–71. doi:10.1016/S0006-2952(02)01615-5. PMID   12628490.
• Bodo A, Bakos E, Szeri F, Varadi A, Sarkadi B (2003). "Differential modulation of the human liver conjugate transporters MRP2 and MRP3 by bile acids and organic anions". J. Biol. Chem. 278 (26): 23529–37. doi: 10.1074/jbc.M303515200 . PMID   12704183.
• Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance". Genome Biol. 5 (2): R8. doi: 10.1186/gb-2004-5-2-r8 . PMC   395752 . PMID   14759258.
• Lang T, Hitzl M, Burk O, Mornhinweg E, Keil A, Kerb R, Klein K, Zanger UM, Eichelbaum M, Fromm MF (2004). "Genetic polymorphisms in the multidrug resistance-associated protein 3 (ABCC3, MRP3) gene and relationship to its mRNA and protein expression in human liver". Pharmacogenetics. 14 (3): 155–64. doi:10.1097/00008571-200403000-00003. PMID   15167703.

External links

• ABCC3+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Human ABCC3 genome location and ABCC3 gene details page in the UCSC Genome Browser .

This article incorporates text from the United States National Library of Medicine, which is in the public domain.