ABCF1

ABCF1
Identifiers
Aliases	ABCF1 , ABC27, ABC50, ATP binding cassette subfamily F member 1
External IDs	OMIM: 603429; MGI: 1351658; HomoloGene: 849; GeneCards: ABCF1; OMA:ABCF1 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6p21.33 Start 30,571,393 bp [1] End 30,597,179 bp [1]
Gene location (Mouse) Chr. Chromosome 17 (mouse) [2] Band 17 B1|17 18.8 cM Start 36,267,711 bp [2] End 36,280,653 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve gastrocnemius muscle skeletal muscle tissue islet of Langerhans muscle of thigh placenta ventricular zone mucosa of transverse colon stromal cell of endometrium granulocyte Top expressed in neural layer of retina tail of embryo Rostral migratory stream genital tubercle yolk sac condyle primitive streak lacrimal gland fetal liver hematopoietic progenitor cell fossa More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotide binding ribosome binding translation activator activity translation factor activity, RNA binding ATPase activity protein binding ATP binding RNA binding Cellular component cytoplasm ribosome nuclear envelope membrane nucleoplasm nucleus polysomal ribosome cytosol Biological process protein biosynthesis ribosome biogenesis positive regulation of translation transmembrane transport translational initiation inflammatory response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23 224742 Ensembl ENSG00000206490 ENSG00000225989 ENSG00000236149 ENSG00000232169 ENSG00000204574 ENSG00000236342 ENSG00000231129 ENSMUSG00000038762 UniProt Q8NE71 Q6P542 RefSeq (mRNA) NM_001090 NM_001025091 NM_013854 RefSeq (protein) NP_001020262 NP_001081 NP_038882 Location (UCSC) Chr 6: 30.57 – 30.6 Mb Chr 17: 36.27 – 36.28 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

ATP-binding cassette sub-family F member 1 is a protein that in humans is encoded by the ABCF1 gene. ^{[5] [6]}

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the GCN20 subfamily. Unlike other members of the superfamily, this protein lacks the transmembrane domains, characteristic of most ABC transporters. This protein may be regulated by tumor necrosis factor-alpha and play a role in enhancing protein synthesis and inflammation. ^[6]

See also

• ATP-binding cassette transporter

References

1. ENSG00000225989, ENSG00000236149, ENSG00000232169, ENSG00000204574, ENSG00000236342, ENSG00000231129 GRCh38: Ensembl release 89: ENSG00000206490, ENSG00000225989, ENSG00000236149, ENSG00000232169, ENSG00000204574, ENSG00000236342, ENSG00000231129 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038762 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Richard M, Drouin R, Beaulieu AD (Dec 1998). "ABC50, a novel human ATP-binding cassette protein found in tumor necrosis factor-alpha-stimulated synoviocytes". Genomics. 53 (2): 137–45. doi:10.1006/geno.1998.5480. PMID   9790762.
6. "Entrez Gene: ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1".

Further reading

• Klein I, Sarkadi B, Váradi A (2000). "An inventory of the human ABC proteins". Biochim. Biophys. Acta. 1461 (2): 237–62. doi: 10.1016/s0005-2736(99)00161-3 . PMID   10581359.
• You KT, Li LS, Kim NG, et al. (2007). "Selective Translational Repression of Truncated Proteins from Frameshift Mutation-Derived mRNAs in Tumors". PLOS Biol. 5 (5): e109. doi: 10.1371/journal.pbio.0050109 . PMC   1854916 . PMID   17456004.
• Ota M, Katsuyama Y, Hamano H, et al. (2007). "Two critical genes (HLA-DRB1 and ABCF1)in the HLA region are associated with the susceptibility to autoimmune pancreatitis". Immunogenetics. 59 (1): 45–52. doi:10.1007/s00251-006-0178-2. PMID   17119950. S2CID   23164855.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID   16964243. S2CID   14294292.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi: 10.1074/mcp.M400085-MCP200 . PMID   15345747.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi: 10.1038/nature02055 . PMID   14574404.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Tyzack JK, Wang X, Belsham GJ, Proud CG (2000). "ABC50 interacts with eukaryotic initiation factor 2 and associates with the ribosome in an ATP-dependent manner". J. Biol. Chem. 275 (44): 34131–9. doi: 10.1074/jbc.M002868200 . PMID   10931828.

External links

• ABCF1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Human ABCF1 genome location and ABCF1 gene details page in the UCSC Genome Browser .

This article incorporates text from the United States National Library of Medicine, which is in the public domain.