ABCC9

ABCC9
Identifiers
Aliases	ABCC9 , ABC37, ATFB12, CANTU, CMD1O, SUR2, ATP binding cassette subfamily C member 9, IDMYS
External IDs	OMIM: 601439; MGI: 1352630; HomoloGene: 56521; GeneCards: ABCC9; OMA:ABCC9 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12p12.1 Start 21,797,389 bp [1] End 21,942,543 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6 G2|6 74.35 cM Start 142,533,588 bp [2] End 142,648,041 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gastrocnemius muscle muscle of thigh Achilles tendon left ventricle apex of heart right lobe of liver gastric mucosa stromal cell of endometrium buccal mucosa cell body of uterus Top expressed in triceps brachii muscle sternocleidomastoid muscle temporal muscle digastric muscle body of femur ankle ascending aorta myocardium of ventricle soleus muscle intercostal muscle More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotide binding transmembrane transporter binding transporter activity potassium channel regulator activity sulfonylurea receptor activity ATPase activity ATP binding ATPase-coupled inorganic anion transmembrane transporter activity potassium channel activity ATPase-coupled transmembrane transporter activity Cellular component integral component of membrane membrane plasma membrane sarcomere sarcolemma inward rectifying potassium channel Biological process potassium ion transport defense response to virus signal transduction transmembrane transport potassium ion import across plasma membrane regulation of cardiac conduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10060 20928 Ensembl ENSG00000069431 ENSMUSG00000030249 UniProt O60706 Q8N4N7 P70170 RefSeq (mRNA) NM_005691 NM_020297 NM_020298 NM_001377273 NM_001377274 NM_001044720 NM_011511 NM_021041 NM_021042 NM_021043 NM_001310143 RefSeq (protein) NP_005682 NP_064693 NP_001364202 NP_001364203 NP_001038185 NP_001297072 NP_035641 NP_066378 NP_066379 Location (UCSC) Chr 12: 21.8 – 21.94 Mb Chr 6: 142.53 – 142.65 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

ATP-binding cassette, sub-family C member 9 (ABCC9) also known as sulfonylurea receptor 2 (SUR2) is an ATP-binding cassette transporter that in humans is encoded by the ABCC9 gene. ^{[5] [6]}

Function

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is thought to form ATP-sensitive potassium channels in cardiac, skeletal, and vascular and non-vascular smooth muscle. Protein structure suggests a role as the drug-binding channel-modulating subunit of the extrapancreatic ATP-sensitive potassium channels. Alternative splicing of this gene results in several products, two of which result from differential usage of two terminal exons and one of which results from exon deletion. ^[7]

• SUR2A — uses exon 38A
• SUR2B — uses exon 38B
• SUR-delta-14 — lack exon 14 and uses exon 38A

Clinical significance

The gene has been associated with dilated cardiomyopathy and Cantú syndrome. ^{[6] [8]}

A variant has also been associated with circa 25 minutes more sleep per day in humans; lack thereof has been associated with three hours less sleep per day in fruit flies. ^{[9] [10]}

A study involving 12,901 individuals from Iceland demonstrated a link between variants of the ABCC9 gene and higher vocal pitch in both men and women. This discovery establishes ABCC9 as the first identified genetic locus associated with vocal pitch. ^[11]

See also

• Sulfonylurea receptor

References

1. GRCh38: Ensembl release 89: ENSG00000069431 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030249 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Aguilar-Bryan L, Clement JP, Gonzalez G, Kunjilwar K, Babenko A, Bryan J (January 1998). "Toward understanding the assembly and structure of KATP channels". Physiological Reviews. 78 (1): 227–245. doi:10.1152/physrev.1998.78.1.227. PMID   9457174. S2CID   11851627.
6. Bienengraeber M, Olson TM, Selivanov VA, Kathmann EC, O'Cochlain F, Gao F, et al. (April 2004). "ABCC9 mutations identified in human dilated cardiomyopathy disrupt catalytic KATP channel gating". Nature Genetics. 36 (4): 382–387. doi:10.1038/ng1329. PMC   1995438 . PMID   15034580.
7. "Entrez Gene: ABCC9, ATP-binding cassette, sub-family C (CFTR/MRP), member 9".
8. Harakalova M, van Harssel JJ, Terhal PA, van Lieshout S, Duran K, Renkens I, et al. (May 2012). "Dominant missense mutations in ABCC9 cause Cantú syndrome". Nature Genetics. 44 (7): 793–796. doi:10.1038/ng.2324. PMID   22610116. S2CID   205345718.
9. "The ABCC9 of sleep: A genetic factor regulates how long we sleep".
10. Allebrandt KV, Amin N, Müller-Myhsok B, Esko T, Teder-Laving M, Azevedo RV, et al. (January 2013). "A K(ATP) channel gene effect on sleep duration: from genome-wide association studies to function in Drosophila". Molecular Psychiatry. 18 (1): 122–132. doi: 10.1038/mp.2011.142 . PMID   22105623.
11. Gisladottir RS, Helgason A, Halldorsson BV, Helgason H, Borsky M, Chien YR, et al. (June 2023). "Sequence variants affecting voice pitch in humans". Science Advances. 9 (23): eabq2969. Bibcode:2023SciA....9.2969G. doi:10.1126/sciadv.abq2969. PMC   10256171 . PMID   37294764.

Further reading

• Jiao J, Garg V, Yang B, Elton TS, Hu K (September 2008). "Protein kinase C-epsilon induces caveolin-dependent internalization of vascular adenosine 5'-triphosphate-sensitive K+ channels". Hypertension. 52 (3): 499–506. doi: 10.1161/HYPERTENSIONAHA.108.110817 . PMID   18663158.
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–1178. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Croker B, Crozat K, Berger M, Xia Y, Sovath S, Schaffer L, et al. (December 2007). "ATP-sensitive potassium channels mediate survival during infection in mammals and insects". Nature Genetics. 39 (12): 1453–1460. doi:10.1038/ng.2007.25. PMID   18026101. S2CID   41183715.
• Kang Y, Ng B, Leung YM, He Y, Xie H, Lodwick D, et al. (July 2006). "Syntaxin-1A actions on sulfonylurea receptor 2A can block acidic pH-induced cardiac K(ATP) channel activation". The Journal of Biological Chemistry. 281 (28): 19019–19028. doi: 10.1074/jbc.M513160200 . PMID   16672225.
• Saito A, Kawamoto M, Kamatani N (June 2009). "Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects". Journal of Human Genetics. 54 (6): 317–323. doi: 10.1038/jhg.2009.31 . PMID   19343046.
• Insuk SO, Chae MR, Choi JW, Yang DK, Sim JH, Lee SW (August 2003). "Molecular basis and characteristics of KATP channel in human corporal smooth muscle cells". International Journal of Impotence Research. 15 (4): 258–266. doi: 10.1038/sj.ijir.3901013 . PMID   12934053.
• Singh H, Hudman D, Lawrence CL, Rainbow RD, Lodwick D, Norman RI (May 2003). "Distribution of Kir6.0 and SUR2 ATP-sensitive potassium channel subunits in isolated ventricular myocytes". Journal of Molecular and Cellular Cardiology. 35 (5): 445–459. doi:10.1016/S0022-2828(03)00041-5. hdl: 2381/14 . PMID   12738227.
• Jöns T, Wittschieber D, Beyer A, Meier C, Brune A, Thomzig A, et al. (August 2006). "K+-ATP-channel-related protein complexes: potential transducers in the regulation of epithelial tight junction permeability". Journal of Cell Science. 119 (Pt 15): 3087–3097. doi:10.1242/jcs.03041. PMID   16820413. S2CID   21379360.
• Minoretti P, Falcone C, Aldeghi A, Olivieri V, Mori F, Emanuele E, et al. (August 2006). "A novel Val734Ile variant in the ABCC9 gene associated with myocardial infarction". Clinica Chimica Acta; International Journal of Clinical Chemistry. 370 (1–2): 124–128. doi:10.1016/j.cca.2006.02.007. PMID   16563363.
• Kang Y, Leung YM, Manning-Fox JE, Xia F, Xie H, Sheu L, et al. (November 2004). "Syntaxin-1A inhibits cardiac KATP channels by its actions on nucleotide binding folds 1 and 2 of sulfonylurea receptor 2A". The Journal of Biological Chemistry. 279 (45): 47125–47131. doi: 10.1074/jbc.M404954200 . PMID   15339904.
• Burke MA, Mutharasan RK, Ardehali H (February 2008). "The sulfonylurea receptor, an atypical ATP-binding cassette protein, and its regulation of the KATP channel". Circulation Research. 102 (2): 164–176. doi: 10.1161/CIRCRESAHA.107.165324 . PMID   18239147.
• Ellis JA, Lamantia A, Chavez R, Scurrah KJ, Nichols CG, Harrap SB (February 2010). "Genes controlling postural changes in blood pressure: comprehensive association analysis of ATP-sensitive potassium channel genes KCNJ8 and ABCC9". Physiological Genomics. 40 (3): 184–188. doi:10.1152/physiolgenomics.00173.2009. PMID   19952277. S2CID   6561063.
• Sato N, Nakayama T, Asai S, Soma M (January 2006). "A haplotype in the human Sur2 gene is associated with essential hypertension". Journal of Human Hypertension. 20 (1): 87–90. doi:10.1038/sj.jhh.1001943. PMID   16267564. S2CID   20035057.
• Curley M, Cairns MT, Friel AM, McMeel OM, Morrison JJ, Smith TJ (October 2002). "Expression of mRNA transcripts for ATP-sensitive potassium channels in human myometrium". Molecular Human Reproduction. 8 (10): 941–945. doi: 10.1093/molehr/8.10.941 . hdl: 10379/9031 . PMID   12356945.
• Ploug KB, Sørensen MA, Strøbech L, Klaerke DA, Hay-Schmidt A, Sheykhzade M, et al. (December 2008). "K ATP channels in pig and human intracranial arteries". European Journal of Pharmacology. 601 (1–3): 43–49. doi:10.1016/j.ejphar.2008.10.041. PMID   18996111.
• Garg V, Sun W, Hu K (July 2009). "Caveolin-3 negatively regulates recombinant cardiac K(ATP) channels". Biochemical and Biophysical Research Communications. 385 (3): 472–477. doi:10.1016/j.bbrc.2009.05.100. PMID   19481058.

External links

• ABCC9 human gene location in the UCSC Genome Browser .
• ABCC9 human gene details in the UCSC Genome Browser .

This article incorporates text from the United States National Library of Medicine, which is in the public domain.