ABCF2

ABCF2
Identifiers
Aliases	ABCF2 , ABC28, EST133090, HUSSY18, HUSSY-18, ATP binding cassette subfamily F member 2
External IDs	OMIM: 612510 MGI: 1351657 HomoloGene: 21408 GeneCards: ABCF2
Gene location (Human) Chr. Chromosome 7 (human) [1] Band 7q36.1 Start 151,211,484 bp [1] End 151,227,205 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5|5 A3 Start 24,770,343 bp [2] End 24,782,465 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve gastrocnemius muscle tibialis anterior muscle endothelial cell secondary oocyte prefrontal cortex Brodmann area 9 left ventricle deltoid muscle stromal cell of endometrium Top expressed in spermatid spermatocyte morula seminiferous tubule somite superior frontal gyrus maxillary prominence lip secondary oocyte primitive streak More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding ATPase activity ATP binding transporter activity Cellular component ATP-binding cassette (ABC) transporter complex mitochondrial envelope membrane mitochondrion Biological process transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10061 27407 Ensembl ENSG00000033050 ENSMUSG00000028953 UniProt Q9UG63 Q99LE6 RefSeq (mRNA) NM_007189 NM_001190443 NM_013853 NM_001359205 RefSeq (protein) NP_005683 NP_009120 NP_001177372 NP_038881 NP_001346134 Location (UCSC) Chr 7: 151.21 – 151.23 Mb Chr 5: 24.77 – 24.78 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

ATP-binding cassette sub-family F member 2 is a protein that in humans is encoded by the ABCF2 gene. ^{[5] [6]}

Function

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, and White). This protein is a member of the GCN20 subfamily. Alternative splicing of this gene results in multiple transcript variants. ^[6]

ABCF2 acts as a suppressor of the volume-sensitive outwardly rectifying Cl channel (CLCN3). ^[7]

See also

• ATP-binding cassette transporter

References

1. GRCh38: Ensembl release 89: ENSG00000033050 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028953 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Allikmets R, Gerrard B, Hutchinson A, Dean M (October 1996). "Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database". Human Molecular Genetics. 5 (10): 1649–55. doi: 10.1093/hmg/5.10.1649 . PMID   8894702.
6. "Entrez Gene: ABCF2 ATP-binding cassette, sub-family F (GCN20), member 2".
7. Ando-Akatsuka Y, Shimizu T, Numata T, Okada Y (2012). "Involvements of the ABC protein ABCF2 and α-actinin-4 in regulation of cell volume and anion channels in human epithelial cells". Journal of Cellular Physiology. 227 (10): 3498–510. doi:10.1002/jcp.24050. PMID   22252987. S2CID   22139132.

Further reading

• Klein I, Sarkadi B, Váradi A (December 1999). "An inventory of the human ABC proteins". Biochimica et Biophysica Acta (BBA) - Biomembranes. 1461 (2): 237–62. doi: 10.1016/s0005-2736(99)00161-3 . PMID   10581359.
• Dean M, Rzhetsky A, Allikmets R (July 2001). "The human ATP-binding cassette (ABC) transporter superfamily". Genome Research. 11 (7): 1156–66. doi: 10.1101/gr.184901 . PMID   11435397. S2CID   9528197.
• Hogue DL, Liu L, Ling V (January 1999). "Identification and characterization of a mammalian mitochondrial ATP-binding cassette membrane protein". Journal of Molecular Biology. 285 (1): 379–89. doi:10.1006/jmbi.1998.2259. PMID   9878413.
• Zhang F, Hogue DL, Liu L, Fisher CL, Hui D, Childs S, Ling V (July 2000). "M-ABC2, a new human mitochondrial ATP-binding cassette membrane protein". FEBS Letters. 478 (1–2): 89–94. doi: 10.1016/S0014-5793(00)01823-8 . PMID   10922475. S2CID   41556343.
• Ye Z, Connor JR (August 2000). "cDNA cloning by amplification of circularized first strand cDNAs reveals non-IRE-regulated iron-responsive mRNAs". Biochemical and Biophysical Research Communications. 275 (1): 223–7. doi:10.1006/bbrc.2000.3282. PMID   10944468.
• Stanchi F, Bertocco E, Toppo S, Dioguardi R, Simionati B, Cannata N, Zimbello R, Lanfranchi G, Valle G (January 2001). "Characterization of 16 novel human genes showing high similarity to yeast sequences". Yeast. 18 (1): 69–80. doi: 10.1002/1097-0061(200101)18:1<69::AID-YEA647>3.0.CO;2-H . PMID   11124703. S2CID   21397515.
• Tsuda H, Ito YM, Ohashi Y, Wong KK, Hashiguchi Y, Welch WR, Berkowitz RS, Birrer MJ, Mok SC (October 2005). "Identification of overexpression and amplification of ABCF2 in clear cell ovarian adenocarcinomas by cDNA microarray analyses". Clinical Cancer Research. 11 (19 Pt 1): 6880–8. doi:10.1158/1078-0432.CCR-05-0751. PMID   16203778. S2CID   27248404.
• Nishimura S, Tsuda H, Ito K, Jobo T, Yaegashi N, Inoue T, Sudo T, Berkowitz RS, Mok SC (January 2007). "Differential expression of ABCF2 protein among different histologic types of epithelial ovarian cancer and in clear cell adenocarcinomas of different organs". Human Pathology. 38 (1): 134–9. doi:10.1016/j.humpath.2006.06.026. PMID   16996567.

External links

• ABCF2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• ABCF2 human gene location in the UCSC Genome Browser .
• ABCF2 human gene details in the UCSC Genome Browser .

This article incorporates text from the United States National Library of Medicine, which is in the public domain.