Acrylyl-CoA reductase (NADH)

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Acrylyl-CoA reductase (NADH)
Identifiers
EC no. 1.3.1.95
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Acrylyl-CoA reductase (NADH) (EC 1.3.1.95) is an enzyme with systematic name propanoyl-CoA:NAD+ oxidoreductase. [1] [2] This enzyme catalyses the following chemical reaction

propanoyl-CoA + NAD+ acryloyl-CoA + NADH + H+

The reaction is catalysed in the opposite direction.

Related Research Articles

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Chlorophyllide a and Chlorophyllide b are the biosynthetic precursors of chlorophyll a and chlorophyll b respectively. Their propionic acid groups are converted to phytyl esters by the enzyme chlorophyll synthase in the final step of the pathway. Thus the main interest in these chemical compounds has been in the study of chlorophyll biosynthesis in plants, algae and cyanobacteria. Chlorophyllide a is also an intermediate in the biosynthesis of bacteriochlorophylls.

References

  1. Hetzel M, Brock M, Selmer T, Pierik AJ, Golding BT, Buckel W (March 2003). "Acryloyl-CoA reductase from Clostridium propionicum. An enzyme complex of propionyl-CoA dehydrogenase and electron-transferring flavoprotein". European Journal of Biochemistry. 270 (5): 902–10. doi: 10.1046/j.1432-1033.2003.03450.x . PMID   12603323.
  2. Kandasamy V, Vaidyanathan H, Djurdjevic I, Jayamani E, Ramachandran KB, Buckel W, Jayaraman G, Ramalingam S (February 2013). "Engineering Escherichia coli with acrylate pathway genes for propionic acid synthesis and its impact on mixed-acid fermentation". Applied Microbiology and Biotechnology. 97 (3): 1191–200. doi:10.1007/s00253-012-4274-y. PMID   22810300.