Alcohol dehydrogenase (cytochrome c)

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Alcohol dehydrogenase (cytochrome c)
Identifiers
EC no. 1.1.2.8
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Alcohol dehydrogenase (cytochrome c) (EC 1.1.2.8, type I quinoprotein alcohol dehydrogenase, quinoprotein ethanol dehydrogenase) is an enzyme with systematic name alcohol:cytochrome c oxidoreductase. [1] [2] [3] [4] [5] [6] This enzyme catalyses the following chemical reaction

a primary alcohol + 2 ferricytochrome c an aldehyde + 2 ferrocytochrome c + 2 H+

A periplasmic PQQ-containing quinoprotein is present in Pseudomonas and Rhodopseudomonas .

References

  1. ↑ Rupp M, Görisch H (June 1988). "Purification, crystallisation and characterization of quinoprotein ethanol dehydrogenase from Pseudomonas aeruginosa". Biological Chemistry Hoppe-Seyler. 369 (6): 431–9. doi:10.1515/bchm3.1988.369.1.431. PMID   3144289.
  2. ↑ Toyama H, Fujii A, Matsushita K, Shinagawa E, Ameyama M, Adachi O (May 1995). "Three distinct quinoprotein alcohol dehydrogenases are expressed when Pseudomonas putida is grown on different alcohols". Journal of Bacteriology. 177 (9): 2442–50. doi:10.1128/jb.177.9.2442-2450.1995. PMC   176903 . PMID   7730276.
  3. ↑ Schobert M, Görisch H (February 1999). "Cytochrome c550 is an essential component of the quinoprotein ethanol oxidation system in Pseudomonas aeruginosa: cloning and sequencing of the genes encoding cytochrome c550 and an adjacent acetaldehyde dehydrogenase". Microbiology. 145 ( Pt 2) (2): 471–81. doi: 10.1099/13500872-145-2-471 . PMID   10075429.
  4. ↑ Keitel T, Diehl A, Knaute T, Stezowski JJ, Höhne W, Görisch H (April 2000). "X-ray structure of the quinoprotein ethanol dehydrogenase from Pseudomonas aeruginosa: basis of substrate specificity". Journal of Molecular Biology. 297 (4): 961–74. doi:10.1006/jmbi.2000.3603. PMID   10736230.
  5. ↑ Kay CW, Mennenga B, Görisch H, Bittl R (April 2004). "Characterisation of the PQQ cofactor radical in quinoprotein ethanol dehydrogenase of Pseudomonas aeruginosa by electron paramagnetic resonance spectroscopy". FEBS Letters. 564 (1–2): 69–72. Bibcode:2004FEBSL.564...69K. doi:10.1016/S0014-5793(04)00317-5. PMID   15094044.
  6. ↑ Mennenga B, Kay CW, Görisch H (April 2009). "Quinoprotein ethanol dehydrogenase from Pseudomonas aeruginosa: the unusual disulfide ring formed by adjacent cysteine residues is essential for efficient electron transfer to cytochrome c550". Archives of Microbiology. 191 (4): 361–7. doi:10.1007/s00203-009-0460-4. PMID   19224199.
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