The polyol pathway is a two-step process that converts glucose to fructose. In this pathway glucose is reduced to sorbitol, which is subsequently oxidized to fructose. It is also called the sorbitol-aldose reductase pathway.
In enzymology, aldose reductase is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides. It is primarily known for catalyzing the reduction of glucose to sorbitol, the first step in polyol pathway of glucose metabolism.
Sorbitol dehydrogenase is a cytosolic enzyme. In humans this protein is encoded by the SORD gene.
In enzymology, a sorbitol-6-phosphate dehydrogenase (EC 1.1.1.140) is an enzyme that catalyzes the chemical reaction
In enzymology, an acylglycerone-phosphate reductase (EC 1.1.1.101) is an enzyme that catalyzes the chemical reaction
In enzymology, a dTDP-4-dehydro-6-deoxyglucose reductase (EC 1.1.1.266) is an enzyme that catalyzes the chemical reaction
In enzymology, a dTDP-4-dehydrorhamnose reductase (EC 1.1.1.133) is an enzyme that catalyzes the chemical reaction
In enzymology, a D-xylose 1-dehydrogenase (NADP+) (EC 1.1.1.179) is an enzyme that catalyzes the chemical reaction
In enzymology, a fructose 5-dehydrogenase (NADP+) (EC 1.1.1.124) is an enzyme that catalyzes the chemical reaction
In enzymology, a glucose 1-dehydrogenase (NADP+) (EC 1.1.1.119) is an enzyme that catalyzes the chemical reaction
In enzymology, a glycerol 2-dehydrogenase (NADP+) (EC 1.1.1.156) is an enzyme that catalyzes the chemical reaction
In enzymology, a mannose-6-phosphate 6-reductase (EC 1.1.1.224) is an enzyme that catalyzes the chemical reaction
In enzymology, a mannuronate reductase (EC 1.1.1.131) is an enzyme that catalyzes the chemical reaction
In enzymology, a mevaldate reductase (NADPH) (EC 1.1.1.33) is an enzyme that catalyzes the chemical reaction
In enzymology, a sorbose 5-dehydrogenase (NADP+) (EC 1.1.1.123) is an enzyme that catalyzes the chemical reaction
In enzymology, an enoyl-[acyl-carrier-protein] reductase (NADPH, A-specific) (EC 1.3.1.39) is an enzyme that catalyzes the chemical reaction
In enzymology, a N-acetyl-gamma-glutamyl-phosphate reductase (EC 1.2.1.38) is an enzyme that catalyzes the chemical reaction
Bis-gamma-glutamylcystine reductase (EC 1.8.1.13) is an enzyme that catalyzes the chemical reaction
In enzymology, a NADPH—cytochrome-c2 reductase (EC 1.6.2.5) is an enzyme that catalyzes the chemical reaction
Aldo-keto reductase family 1, member B1 (AKR1B1), also known as aldose reductase, is an enzyme that is encoded by the AKR1B1 gene in humans. It is a reduced nicotinamide-adenine dinucleotide phosphate (NADPH)-dependent enzyme catalyzing the reduction of various aldehydes and ketones to the corresponding alcohol. The involvement of AKR1B1 in oxidative stress diseases, cell signal transduction, and cell proliferation process endows AKR1B1 with potential as a therapeutic target.
