Angiopathy

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Angiopathy is the generic term for a disease of the blood vessels (arteries, veins, and capillaries). [1] This also refers to the condition of damage or rupture of small blood vessels. The best known and most prevalent angiopathy is diabetic angiopathy , a common complication of chronic diabetes.

Contents

Classification

By caliber

There are two types of angiopathy: macroangiopathy and microangiopathy . [2]

In macroangiopathy, atherosclerosis and a resultant blood clot forms on the large blood vessels, sticks to the vessel walls, and blocks the flow of blood. Macroangiopathy in the heart is coronary artery disease; in the brain, it is cerebrovascular disease. Macroangiopathy may cause other complications, such as ischemic heart disease, stroke and peripheral vascular disease which contributes to the diabetic foot ulcers and the risk of amputation.

In microangiopathy, the walls of the smaller blood vessels become so thick and weak that they bleed, leak protein, and slow the flow of blood through the body. The decrease of blood flow through stenosis or clot formation impairs the flow of oxygen to cells and biological tissues (called ischemia) and leads to cellular death (necrosis and gangrene, which in turn may require amputation). Thus, tissues which are very sensitive to oxygen levels, such as the retina, develop microangiopathy and may cause blindness (so-called proliferative diabetic retinopathy). Damage to nerve cells may cause peripheral neuropathy, and to kidney cells, diabetic kidney disease (Kimmelstiel-Wilson syndrome).

By condition

It is also possible to classify angiopathy by the associated condition: [3]

Chronic diabetes can lead to several problems, one of which is Diabetic Angiopathy. Individuals with diabetic angiopathy notice a constriction in their arteries. This cause many organs to receive insufficient blood and oxygen, which might eventually cause harm. High blood sugar is the primary cause of diabetic angiopathy. Excessive blood sugar levels have the potential to harm tissues and cells. [4]

A form of cerebrovascular illness known as Cerebral Amyloid Angiopathy (CAA) is typified by the buildup of amyloid beta-peptide in the leptomeninges and small to medium sized cerebral blood vessels. [5] Amyloid buildup causes brittle blood vessels, which can lead to lobar intracerebral hemorrhages (ICH). In addition, hemosiderosis, inflammatory leukoencephalopathy, Alzheimer's disease, accidental microbleeds, cognitive deficits, and transitory neurological symptoms may manifest. [6]

Causes

The cause of Cerebral Amyloid Angiopathy are unknown. Sometimes it can be hereditary, however, there have been cases where it is developed in the elderly, especially in people over 55 years of age. [3]

High blood sugar is the primary cause of diabetic angiopathy. The endothelium, a smooth layer of the cell wall, is weakened and the artery-lining cells are injured. Rough patches develop along the endothelium and may promote the accumulation of deposits known as plaque. These deposits gradually harden and become more noticeable over time, restricting (stenosing) the artery and impairing normal blood flow. Different organs receive insufficient oxygen-rich blood due to the bottleneck that was formed. [4]

Symptoms

Individuals with cerebral amyloid angiopathy typically have no symptoms. However, spontaneous lobar bleeding is the most frequent clinical sign when symptomatic. The clinical impairments are primarily determined by the site and extent of the bleeding. Larger hemorrhages may result in greater focused deficits, headaches, seizures, speaking difficulties, and muscular weakness. Smaller hemorrhages may produce hemiplegia and diminished consciousness. [7]

Treatment

Currently, while there is no cure for angiopathy, there are ways through which the symptoms can be managed. For example, therapies. Treatment options for situations of muscle weakness may include speech, occupational, or physical therapy. Medication can be used for potential seizures and memory loss. [3]

lobar intracerebral hemorrhages(ICH) linked to CAA is often recurring. Due to this high prevalence, when there isn't a clear justification for anticoagulation, doctors usually avoid antiplatelet medicines and anticoagulants. Notably, research has shown that people with atrial fibrillation benefit from restarting anticoagulation. [8]

Despite the fact that CAA does not appear to be primarily caused by hypertension, blood pressure reduction has also been linked to advantages in terms of mortality.[8] Blood pressure control reduced the risk of CAA-related ICH by 77%. [9]

Finally, a small body of research has demonstrated the advantages of using immunosuppression to treat the inflammatory forms of CAA. [10]


Related Research Articles

<span class="mw-page-title-main">Intracranial aneurysm</span> Ballooning or rupturing of a blood vessel in the brain

An intracranial aneurysm, also known as a cerebral aneurysm, is a cerebrovascular disorder characterized by a localized dilation or ballooning of a blood vessel in the brain due to a weakness in the vessel wall. These aneurysms can occur in any part of the brain but are most commonly found in the arteries of the circle of Willis. The risk of rupture varies with the size and location of the aneurysm, with those in the posterior circulation being more prone to rupture.

<span class="mw-page-title-main">Vascular dementia</span> Dementia resulting from stroke

Vascular dementia is dementia caused by a series of strokes. Restricted blood flow due to strokes reduces oxygen and glucose delivery to the brain, causing cell injury and neurological deficits in the affected region. Subtypes of vascular dementia include subcortical vascular dementia, multi-infarct dementia, stroke-related dementia, and mixed dementia.

<span class="mw-page-title-main">Cerebrovascular disease</span> Condition that affects the arteries that supply the brain

Cerebrovascular disease includes a variety of medical conditions that affect the blood vessels of the brain and the cerebral circulation. Arteries supplying oxygen and nutrients to the brain are often damaged or deformed in these disorders. The most common presentation of cerebrovascular disease is an ischemic stroke or mini-stroke and sometimes a hemorrhagic stroke. Hypertension is the most important contributing risk factor for stroke and cerebrovascular diseases as it can change the structure of blood vessels and result in atherosclerosis. Atherosclerosis narrows blood vessels in the brain, resulting in decreased cerebral perfusion. Other risk factors that contribute to stroke include smoking and diabetes. Narrowed cerebral arteries can lead to ischemic stroke, but continually elevated blood pressure can also cause tearing of vessels, leading to a hemorrhagic stroke.

<span class="mw-page-title-main">Microangiopathy</span> Medical condition

Microangiopathy is a disease of the microvessels, small blood vessels in the microcirculation. It can be contrasted to macroangiopathies such as atherosclerosis, where large and medium-sized arteries are primarily affected.

<span class="mw-page-title-main">Cerebral edema</span> Excess accumulation of fluid (edema) in the intracellular or extracellular spaces of the brain

Cerebral edema is excess accumulation of fluid (edema) in the intracellular or extracellular spaces of the brain. This typically causes impaired nerve function, increased pressure within the skull, and can eventually lead to direct compression of brain tissue and blood vessels. Symptoms vary based on the location and extent of edema and generally include headaches, nausea, vomiting, seizures, drowsiness, visual disturbances, dizziness, and in severe cases, death.

<span class="mw-page-title-main">Infarction</span> Tissue death due to inadequate blood supply

Infarction is tissue death (necrosis) due to inadequate blood supply to the affected area. It may be caused by artery blockages, rupture, mechanical compression, or vasoconstriction. The resulting lesion is referred to as an infarct (from the Latin infarctus, "stuffed into").

<span class="mw-page-title-main">Stroke</span> Death of a region of brain cells due to poor blood flow

Stroke is a medical condition in which poor blood flow to the brain causes cell death. There are two main types of stroke:

<span class="mw-page-title-main">Intracranial hemorrhage</span> Hemorrhage, or bleeding, within the skull

Intracranial hemorrhage (ICH), also known as intracranial bleed, is bleeding within the skull. Subtypes are intracerebral bleeds, subarachnoid bleeds, epidural bleeds, and subdural bleeds.

<span class="mw-page-title-main">Cerebral amyloid angiopathy</span> Disease of blood vessels of the brain

Cerebral amyloid angiopathy (CAA) is a form of angiopathy in which amyloid beta peptide deposits in the walls of small to medium blood vessels of the central nervous system and meninges. The term congophilic is sometimes used because the presence of the abnormal aggregations of amyloid can be demonstrated by microscopic examination of brain tissue after staining with Congo red. The amyloid material is only found in the brain and as such the disease is not related to other forms of amyloidosis.

<span class="mw-page-title-main">Perivascular space</span>

A perivascular space, also known as a Virchow–Robin space, is a fluid-filled space surrounding certain blood vessels in several organs, including the brain, potentially having an immunological function, but more broadly a dispersive role for neural and blood-derived messengers. The brain pia mater is reflected from the surface of the brain onto the surface of blood vessels in the subarachnoid space. In the brain, perivascular cuffs are regions of leukocyte aggregation in the perivascular spaces, usually found in patients with viral encephalitis.

<span class="mw-page-title-main">Intracerebral hemorrhage</span> Type of intracranial bleeding that occurs within the brain tissue itself

Intracerebral hemorrhage (ICH), also known as hemorrhagic stroke, is a sudden bleeding into the tissues of the brain, into its ventricles, or into both. An ICH is a type of bleeding within the skull and one kind of stroke. Symptoms can vary dramatically depending on the severity, acuity, and location (anatomically) but can include headache, one-sided weakness, numbness, tingling, or paralysis, speech problems, vision or hearing problems, memory loss, attention problems, coordination problems, balance problems, dizziness or lightheadedness or vertigo, nausea/vomiting, seizures, decreased level of consciousness or total loss of consciousness, neck stiffness, and fever.

<span class="mw-page-title-main">Intraparenchymal hemorrhage</span> Bleeding within parenchymal tissue of the brain

Intraparenchymal hemorrhage (IPH) is one form of intracerebral bleeding in which there is bleeding within brain parenchyma. The other form is intraventricular hemorrhage (IVH).

Diabetic angiopathy is a form of angiopathy associated with diabetic complications. While not exclusive, the two most common forms are diabetic retinopathy and diabetic nephropathy, whose pathophysiologies are largely identical. Other forms of diabetic angiopathy include diabetic neuropathy and diabetic cardiomyopathy.

<span class="mw-page-title-main">Watershed stroke</span> Medical condition

A watershed stroke is defined as a brain ischemia that is localized to the vulnerable border zones between the tissues supplied by the anterior, posterior and middle cerebral arteries. The actual blood stream blockage/restriction site can be located far away from the infarcts. Watershed locations are those border-zone regions in the brain supplied by the major cerebral arteries where blood supply is decreased. Watershed strokes are a concern because they comprise approximately 10% of all ischemic stroke cases. The watershed zones themselves are particularly susceptible to infarction from global ischemia as the distal nature of the vasculature predisposes these areas to be most sensitive to profound hypoperfusion.

Brain ischemia is a condition in which there is insufficient bloodflow to the brain to meet metabolic demand. This leads to poor oxygen supply or cerebral hypoxia and thus leads to the death of brain tissue or cerebral infarction/ischemic stroke. It is a sub-type of stroke along with subarachnoid hemorrhage and intracerebral hemorrhage.

Charcot–Bouchard aneurysms are aneurysms of the brain vasculature which occur in small blood vessels. Charcot–Bouchard aneurysms are most often located in the lenticulostriate vessels of the basal ganglia and are associated with chronic hypertension. Charcot–Bouchard aneurysms are a common cause of cerebral hemorrhage. Charcot–Bouchard aneurysm rupture might be linked to senile plaque formation in the Alzheimer's disease.

<span class="mw-page-title-main">Cerebral atherosclerosis</span> Medical condition

Cerebral atherosclerosis is a type of atherosclerosis where build-up of plaque in the blood vessels of the brain occurs. Some of the main components of the plaques are connective tissue, extracellular matrix, including collagen, proteoglycans, fibronectin, and elastic fibers; crystalline cholesterol, cholesteryl esters, and phospholipids; cells such as monocyte derived macrophages, T-lymphocytes, and smooth muscle cells. The plaque that builds up can lead to further complications such as stroke, as the plaque disrupts blood flow within the intracranial arterioles. This causes the downstream sections of the brain that would normally be supplied by the blocked artery to suffer from ischemia. Diagnosis of the disease is normally done through imaging technology such as angiograms or magnetic resonance imaging. The risk of cerebral atherosclerosis and its associated diseases appears to increase with increasing age; however there are numerous factors that can be controlled in attempt to lessen risk.

<span class="mw-page-title-main">Amyloid-related imaging abnormalities</span> Medical condition

Amyloid-related imaging abnormalities (ARIA) are abnormal differences seen in magnetic resonance imaging of the brain in patients with Alzheimer's disease. ARIA is associated with anti-amyloid drugs, particularly human monoclonal antibodies such as aducanumab. There are two types of ARIA: ARIA-E and ARIA-H. The phenomenon was first seen in trials of bapineuzumab.

Familial Danish dementia is an extremely rare, neurodegenerative disease characterized by progressive cataracts, loss of hearing, cerebellar ataxia, paranoid psychosis, and dementia. Neuropathological hallmarks include extensive atrophy of all areas of the brain, chronic diffuse encephalopathy, and the presence of exceedingly thin and nearly totally demyelinated cranial nerves.

The Boston criteria version 2.0 is a set of guidelines designed to diagnose cerebral amyloid angiopathy (CAA), a disease that affects small blood vessels in the brain, particularly those in the cortex and leptomeninges. Although the gold standard for diagnosis is histopathological examination, the Boston criteria provide clinicians with a probabilistic approach for diagnosis largely based on imaging characteristics.

References

  1. ↑ "angiopathy" at Dorland's Medical Dictionary
  2. ↑ "Medical Definition of Angiopathy". RxList. Retrieved 2024-10-14.
  3. 1 2 3 "Angiopathy: what is it, symptoms and treatment". Top Doctors. Retrieved 2024-10-14.
  4. 1 2 Australia, Bauerfeind. "Bauerfeind Australia". Bauerfeind Australia. Retrieved 2024-10-14.
  5. ↑ A, Viswanathan; SM, Greenberg (2011). "Cerebral amyloid angiopathy in the elderly". Ann Neurol. 70 (6): 871–80 – via National Institute of Health.
  6. ↑ A, Charidimou; Q, Gang; DJ, Werring (2012). "Sporadic cerebral amyloid angiopathy revisited: recent insights into pathophysiology and clinical spectrum". J Neurol Neurosurg Psychiatry. 83 (2): 124–37 – via National Institute of Health.
  7. ↑ Kuhn, James; Sharman, Tariq (2024), "Cerebral Amyloid Angiopathy", StatPearls, Treasure Island (FL): StatPearls Publishing, PMID   32310565 , retrieved 2024-10-14
  8. ↑ Biffi, A.; Battey, T.W.K.; Ayres, A.M.; Cortellini, L.; Schwab, K.; Gilson, A.J.; Rost, N.S.; Viswanathan, A.; Goldstein, J.N.; Greenberg, S.M.; Rosand, J. (2011-11-15). "Warfarin-related intraventricular hemorrhage". Neurology. 77 (20): 1840–1846. doi:10.1212/WNL.0b013e3182377e12. ISSN   0028-3878. PMC   3233208 . PMID   22049204.
  9. ↑ H, Arima; C, Tzourio; C, Anderson; M, Woodward; MG, Bousser; S, MacMahon; B, Neal; J, Chalmers (2010). "Effects of perindopril-based lowering of blood pressure on intracerebral hemorrhage related to amyloid angiopathy: the PROGRESS trial. Stroke". PROGRESS Collaborative Group. 41 (W): 394–6 – via National Institute of Health.
  10. ↑ Kinnecom, C.; Lev, M. H.; Wendell, L.; Smith, E. E.; Rosand, J.; Frosch, M. P.; Greenberg, S. M. (2007-04-24). "Course of cerebral amyloid angiopathy-related inflammation". Neurology. 68 (17): 1411–1416. doi:10.1212/01.wnl.0000260066.98681.2e. ISSN   1526-632X. PMID   17452586.
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