Apolipoprotein C-IV

APOC4
Identifiers
Aliases	APOC4 , APO-CIV, APOC-IV, apolipoprotein C4
External IDs	OMIM: 600745; MGI: 87878; HomoloGene: 1245; GeneCards: APOC4; OMA:APOC4 - orthologs
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19q13.32 Start 44,942,237 bp [1] End 44,945,496 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7 A3|7 9.94 cM Start 19,412,008 bp [2] End 19,415,404 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver testicle mucosa of transverse colon sural nerve left adrenal cortex right adrenal gland right ovary ventricular zone right adrenal cortex gallbladder Top expressed in left lobe of liver gallbladder adrenal gland fetal liver hematopoietic progenitor cell yolk sac sexually immature organism human fetus embryo morula stomach More reference expression data BioGPS n/a
Gene ontology Molecular function lipid transporter activity Cellular component high-density lipoprotein particle extracellular region very-low-density lipoprotein particle Biological process lipid transport positive regulation of sequestering of triglyceride triglyceride homeostasis lipid metabolism very-low-density lipoprotein particle assembly very-low-density lipoprotein particle clearance Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 346 11425 Ensembl ENSG00000267467 ENSMUSG00000074336 UniProt P55056 Q61268 RefSeq (mRNA) NM_001646 NM_007385 RefSeq (protein) NP_001637 NP_031411 Location (UCSC) Chr 19: 44.94 – 44.95 Mb Chr 7: 19.41 – 19.42 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Apolipoprotein C-IV, also known as apolipoprotein C4, is a protein that in humans is encoded by the APOC4 gene. ^{[5] [6]}

Function

APOC4 is a member of the apolipoprotein C gene family. It is expressed in the liver and has a predicted protein structure characteristic of the other genes in this family. APOC4 is a 3.3-kb gene consisting of 3 exons and 2 introns; it is located 0.5 kb 5' to the APOC2 gene. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000267467 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000074336 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: apolipoprotein C-IV".
6. Allan CM, Walker D, Segrest JP, Taylor JM (July 1995). "Identification and characterization of a new human gene (APOC4) in the apolipoprotein E, C-I, and C-II gene locus". Genomics. 28 (2): 291–300. doi:10.1006/geno.1995.1144. PMID   8530039.

External links

• Human APOC4 genome location and APOC4 gene details page in the UCSC Genome Browser .

Further reading

• Kim E, Li K, Lieu C, et al. (2008). "Expression of apolipoprotein C-IV is regulated by Ku antigen/peroxisome proliferator-activated receptor gamma complex and correlates with liver steatosis". J. Hepatol. 49 (5): 787–98. doi:10.1016/j.jhep.2008.06.029. PMC   2644636 . PMID   18809223.
• Burkhardt R, Kenny EE, Lowe JK, et al. (2008). "Common SNPs in HMGCR in micronesians and whites associated with LDL-cholesterol levels affect alternative splicing of exon13". Arterioscler. Thromb. Vasc. Biol. 28 (11): 2078–84. doi:10.1161/ATVBAHA.108.172288. PMC   2764366 . PMID   18802019.
• Willer CJ, Sanna S, Jackson AU, et al. (2008). "Newly identified loci that influence lipid concentrations and risk of coronary artery disease". Nat. Genet. 40 (2): 161–9. doi:10.1038/ng.76. PMC   5206900 . PMID   18193043.
• Mak PA, Laffitte BA, Desrumaux C, et al. (2002). "Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta". J. Biol. Chem. 277 (35): 31900–8. doi: 10.1074/jbc.M202993200 . PMID   12032151.
• Liu T, Qian WJ, Gritsenko MA, et al. (2005). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC   1850943 . PMID   16335952.
• Kathiresan S, Willer CJ, Peloso GM, et al. (2009). "Common variants at 30 loci contribute to polygenic dyslipidemia". Nat. Genet. 41 (1): 56–65. doi:10.1038/ng.291. PMC   2881676 . PMID   19060906.
• Mosbruger TL, Duggal P, Goedert JJ, et al. (2010). "Large-scale candidate gene analysis of spontaneous clearance of hepatitis C virus". J. Infect. Dis. 201 (9): 1371–80. doi:10.1086/651606. PMC   2853721 . PMID   20331378.
• Ken-Dror G, Talmud PJ, Humphries SE, Drenos F (2010). "APOE/C1/C4/C2 gene cluster genotypes, haplotypes and lipid levels in prospective Coronary Heart Disease Risk among UK healthy men". Molecular Medicine. 16 (9–10): 389–99. doi:10.2119/molmed.2010.00044. PMC   2935949 . PMID   20498921.
• Marques-Vidal P, Bochud M, Paccaud F, et al. (2010). "No interaction between alcohol consumption and HDL-related genes on HDL cholesterol levels". Atherosclerosis. 211 (2): 551–7. doi:10.1016/j.atherosclerosis.2010.04.001. PMID   20430392.
• Talmud PJ, Drenos F, Shah S, et al. (2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. Genet. 85 (5): 628–42. doi:10.1016/j.ajhg.2009.10.014. PMC   2775832 . PMID   19913121.
• Drenos F, Talmud PJ, Casas JP, et al. (2009). "Integrated associations of genotypes with multiple blood biomarkers linked to coronary heart disease risk". Hum. Mol. Genet. 18 (12): 2305–16. doi:10.1093/hmg/ddp159. PMC   2685759 . PMID   19336475.
• Kathiresan S, Melander O, Guiducci C, et al. (2008). "Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans". Nat. Genet. 40 (2): 189–97. doi:10.1038/ng.75. PMC   2682493 . PMID   18193044.
• Mancone C, Amicone L, Fimia GM, et al. (2007). "Proteomic analysis of human very low-density lipoprotein by two-dimensional gel electrophoresis and MALDI-TOF/TOF". Proteomics. 7 (1): 143–54. doi:10.1002/pmic.200600339. PMID   17154273. S2CID   41502305.
• Lowe JK, Maller JB, Pe'er I, et al. (2009). Gibson G (ed.). "Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae". PLOS Genet. 5 (2) e1000365. doi: 10.1371/journal.pgen.1000365 . PMC   2628735 . PMID   19197348.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Kamboh MI, Aston CE, Hamman RF (2000). "DNA sequence variation in human apolipoprotein C4 gene and its effect on plasma lipid profile". Atherosclerosis. 152 (1): 193–201. doi:10.1016/S0021-9150(99)00459-1. PMID   10996355.
• Klos KL, Sing CF, Boerwinkle E, et al. (2006). "Consistent effects of genes involved in reverse cholesterol transport on plasma lipid and apolipoprotein levels in CARDIA participants". Arterioscler. Thromb. Vasc. Biol. 26 (8): 1828–36. doi: 10.1161/01.ATV.0000231523.19199.45 . PMID   16763159.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Kotite L, Zhang LH, Yu Z, et al. (2003). "Human apoC-IV: isolation, characterization, and immunochemical quantification in plasma and plasma lipoproteins". J. Lipid Res. 44 (7): 1387–94. doi: 10.1194/jlr.M300087-JLR200 . PMID   12700345.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.