Capillaria philippinensis

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Capillaria philippinensis
Scientific classification OOjs UI icon edit-ltr.svg
Domain: Eukaryota
Kingdom: Animalia
Phylum: Nematoda
Class: Enoplea
Order: Enoplida
Family: Capillariidae
Genus: Capillaria
Species:
C. philippinensis
Binomial name
Capillaria philippinensis
Velasquez, Chitwood and Salazar, 1968

Capillaria philippinensis is a parasitic nematode which causes intestinal capillariasis. This sometimes fatal disease was first discovered in Northern Luzon, Philippines, in 1964. Cases have also been reported from China, Egypt, Indonesia, Iran, Japan, Korea, Lao PDR, Taiwan and Thailand. [1] Cases diagnosed in Italy and Spain were believed to be acquired abroad, with one case possibly contracted in Colombia. [2] The natural life cycle of C. philippinensis is believed to involve fish as intermediate hosts, and fish-eating birds as definitive hosts. Humans acquire C. philippinensis by eating small species of infested fish whole and raw.

Contents

Discovery and nomenclature

Capillaria philippinensis egg CapillariaPhilippEgg.jpg
Capillaria philippinensis egg

Between the first case reported in 1964 and the end of 1967, more than 1000 cases were documented in and around Northern Luzon particularly at Tagudin, Ilocos Sur, including 77 deaths. Witch doctors were hired by the locals to exorcise the curse placed on them by the river god, which they believed was responsible for this sudden disaster. [3]

In 1968, the cause was identified as Capillaria philippinensis. [4] Adult C. philippinensis are very small, with males measuring 1.5–3.9 mm long and 23–28 µm maximum width, while adult females are 2.3–5.3 mm long and 29–47 µm maximum width. Eggs measure 36–45 µm long and 20 µm wide, and are described as peanut-shaped with a striated shell.

This species has been transferred to the genus Aonchotheca, as Aonchotheca philippinensis, [5] and to the genus Paracapillaria, as Paracapillaria philippinensis. [6] However, this species is almost universally referred to as Capillaria philippinensis in the current medical literature.

Hosts and life cycle

Capillaria philippinensis life cycle Capillariasis Life Cycle.tif
Capillaria philippinensis life cycle

The complete life cycle of C. philippinensis has been demonstrated in experimental studies, and may be either indirect (involving an intermediate host) or direct (complete in one host). [7]

Indirect life cycle. Fish-eating birds which harbor adult C. philippinensis in their intestines, shed embryonated eggs in their feces. When these eggs are fed to uninfected fish, C. philippinensis larvae are recovered from the intestines of fish. If the fish are fed to uninfested birds, the larvae develop into adults in the intestinal tract of the birds. Larvae recovered from the fish also developed into adults when fed to gerbils or monkeys, with eggs shed in the feces of these mammalian hosts. Naturally infested fish (Hypseleotris bipartita and Apagon sp.) and birds ( Ixobrychus sp.) have also been found. Humans become infested when they eat raw or undercooked fish, probably small fish eaten whole, which have the infective larvae in their intestinal tract. Raw fish are commonly eaten by several of the Asian cultures in which C. philippinensis infestations have been found.[ citation needed ]

While the natural host range is not known, experimental infestations of several fishes, including Cyprinus carpio , Puntius gonionotus, Rasbora borapetensis , Eleotris melanosoma , Ambassis commersoni and Apogon sp., with C. philippinensis eggs yielded infective larvae. Experimental infestations with larvae of several birds, including Amaurornis phoenicurus , Ardeola bacchus , Nycticorax nycticorax , Bubulcus ibis , Ixobrychus sinensis , Gallinula chloropus , and Rostratula benghalensis , yielded mature adults.

Direct life cycle. Researchers also found that feeding just a few dozen larvae from the intestines of fish to Mongolian gerbils ( Meriones unguiculatus ) or monkeys ( Macaca sp.) led to infestations with thousands of adult worms through "autoinfection". Autoinfection is when the offspring produced by adults can reinfest the same host, allowing the infestation to multiply within a single host animal. Both oviparous (egg-laying) and larviparous (giving birth to active larvae) adult female C. philippinensis were found in Mongolian gerbils and some birds. The experimentally infested monkeys never developed any clinical symptoms, even during prolonged, active infestations. Of several rodents tested, only Mongolian gerbils developed severe symptoms due to infestation and died.

Pathology

Although C. philippinensis infections are rare, it can serve as an indicator that one is being exposed to raw or undercooked fish. Early diagnosis of the parasite is beneficial so the number of worms in an infected person would not increase. [8]

Worms create infection by penetrating the mucosa of the small intestine and reentering the lumen. As they progress into the body, they cause the mucosa and submucosa to degenerate. Infected people can have abdominal pains, diarrhea, weight loss, weakness, malaise, anorexia, and emaciation. They also experience loss of proteins and electrolytes and malabsorption of fats and sugars. If symptoms and the number of worms increase, it can eventually lead to death.[ citation needed ]

Diagnosis

This parasite can be diagnosed by taking a tissue biopsy from the small intestine or by examining stool samples through a microscope. [9] In a heavily infected person, it is best to examine their feces because it will show an abundance of adult worms and eggs. When looking at the eggs of C. philippinensis, one must be able to distinguish it from the eggs of Trichuris trichiura. C. philippinensis eggs have nonprotruding polar plugs and are slightly smaller than T. trichiura eggs. [10]

Treatment

C. philippinensis infections should be treated with 200 mg of mebendazole. This drug is taken twice a day for 20 days or until all symptoms subside and there are no longer eggs present in the stool samples of the patient. Another drug that may be used is albendazole 400 mg, which is taken orally every day for at least 10 days. [11]

Related Research Articles

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Ascaris lumbricoides is a large parasitic worm that causes ascariasis in humans. A roundworm of genus Ascaris, it is the most common parasitic worm in humans. An estimated one-sixth of the human population is at some point infected by a roundworm such as A. lumbricoides; people living in tropical and subtropical countries are at greater risk of infection.

<i>Trichuris trichiura</i> Parasitic roundworm that causes intestinal infection

Trichuris trichiura, Trichocephalus trichiuris or whipworm, is a parasitic roundworm that causes trichuriasis when it infects a human large intestine. It is commonly known as the whipworm which refers to the shape of the worm; it looks like a whip with wider "handles" at the posterior end.

<i>Strongyloides stercoralis</i> Species of worm

Strongyloides stercoralis is a human pathogenic parasitic roundworm causing the disease strongyloidiasis. Its common name in the US is threadworm. In the UK and Australia, however, the term threadworm can also refer to nematodes of the genus Enterobius, otherwise known as pinworms.

<span class="mw-page-title-main">Ascariasis</span> Disease caused by the parasitic roundworm Ascaris lumbricoides

Ascariasis is a disease caused by the parasitic roundworm Ascaris lumbricoides. Infections have no symptoms in more than 85% of cases, especially if the number of worms is small. Symptoms increase with the number of worms present and may include shortness of breath and fever in the beginning of the disease. These may be followed by symptoms of abdominal swelling, abdominal pain, and diarrhea. Children are most commonly affected, and in this age group the infection may also cause poor weight gain, malnutrition, and learning problems.

<i>Diphyllobothrium</i> Genus of flatworms

Diphyllobothrium is a genus of tapeworms which can cause diphyllobothriasis in humans through consumption of raw or undercooked fish. The principal species causing diphyllobothriasis is D. latum, known as the broad or fish tapeworm, or broad fish tapeworm. D. latum is a pseudophyllid cestode that infects fish and mammals. D. latum is native to Scandinavia, western Russia, and the Baltics, though it is now also present in North America, especially the Pacific Northwest. In Far East Russia, D. klebanovskii, having Pacific salmon as its second intermediate host, was identified.

<i>Necator americanus</i> Species of hookworm

Necator americanus is a species of hookworm commonly known as the New World hookworm. Like other hookworms, it is a member of the phylum Nematoda. It is an obligatory parasitic nematode that lives in the small intestine of human hosts. Necatoriasis—a type of helminthiasis—is the term for the condition of being host to an infestation of a species of Necator. Since N. americanus and Ancylostoma duodenale are the two species of hookworms that most commonly infest humans, they are usually dealt with under the collective heading of "hookworm infection". They differ most obviously in geographical distribution, structure of mouthparts, and relative size.

<i>Anisakis</i> Genus of parasitic nematodes

Anisakis is a genus of parasitic nematodes that have life cycles involving fish and marine mammals. They are infective to humans and cause anisakiasis. People who produce immunoglobulin E in response to this parasite may subsequently have an allergic reaction, including anaphylaxis, after eating fish infected with Anisakis species.

<span class="mw-page-title-main">Eucestoda</span> Subclass of flatworms

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<i>Trichuris suis</i> Species of roundworm

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<span class="mw-page-title-main">Intestinal capillariasis</span> Medical condition

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<i>Capillaria aerophila</i> Species of roundworm

Capillaria aerophila is a nematode parasite found in the respiratory tract of foxes, dogs, and various other carnivorous mammals. A few cases of human infestation have also been reported. Though it is sometimes called a "lungworm", this term usually refers to other species of nematodes. Infestation by C. aerophila is referred to as "pulmonary capillariasis", "bronchial capillariasis," or (rarely) "thominxosis." This parasite has a direct life cycle, meaning that the life cycle can be completed in a single host. C. aerophila usually causes only minor clinical symptoms, such as irritation of the respiratory tract and coughing. However, secondary bacterial infections of the respiratory tract, including pneumonia, may develop in heavy infestations. Treatment with anthelmintics, such as levamisole or fenbendazole, is usually sufficient to cure C. aerophila infestations.

<i>Capillaria hepatica</i> Species of roundworm

Capillaria hepatica is a parasitic nematode which causes hepatic capillariasis in rodents and numerous other mammal species, including humans. The life cycle of C. hepatica may be completed in a single host species. However, the eggs, which are laid in the liver, must mature outside of the host body prior to infecting a new host. So the death of the host in which the adults reach sexual maturity, either by being eaten or dying and decomposing, is necessary for completion of the life cycle.

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Moniliformis moniliformis is a parasite of the Acanthocephala phylum in the family Moniliformidae. The adult worms are usually found in intestines of rodents or carnivores such as cats and dogs. The species can also infest humans, though this is rare.

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Raillietina echinobothrida is a parasitic tapeworm belonging to the class Cestoda. It is the most prevalent and pathogenic helminth parasite in birds, particularly in domestic fowl, Gallus domesticus Linnaeus, 1758. It requires two hosts, birds and ants, for completion of its life cycle. It is a hermaphrodite worm having both the male and female reproductive organs in its body. The parasite is responsible for 'nodular tapeworm disease' in poultry.

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<span class="mw-page-title-main">Nematode infection in dogs</span> Threadworm infections of dogs are frequent

Nematode infection in dogs - the infection of dogs with parasitic nemamotodes - are, along with tapeworm infections and infections with protozoa, frequent parasitoses in veterinary practice. Nematodes, as so-called endoparasites, colonize various internal organs - most of them the digestive tract - and the skin. To date, about 30 different species of nematode have been identified in domestic dogs; they are essentially also found in wild dog species. However, the majority of them often cause no or only minor symptoms of disease in adult animals. The infection therefore does not necessarily have to manifest itself in a worm disease (helminthosis). For most nematodes, an infection can be detected by examining the feces for eggs or larvae. Roundworm infection in dogs and the hookworm in dogs is of particular health significance in Central Europe, as they can also be transmitted to humans (zoonosis). Regular deworming can significantly reduce the frequency of infection and thus the risk of infection for humans and dogs.

References

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