Carbonyl reductase (NADPH)

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carbonyl reductase (NADPH)
1cyd.jpg
carbonyl reductase tetramer, Mouse
Identifiers
EC no. 1.1.1.184
CAS no. 89700-36-7
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO
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PMC articles
PubMed articles
NCBI proteins
Ribbon diagram of human carbonyl reductase 1, in complex with NADPH and a small molecule inhibitor (not shown). From PDB: 1WMA . Carbonyl reductase 1WMA.png
Ribbon diagram of human carbonyl reductase 1, in complex with NADPH and a small molecule inhibitor (not shown). From PDB: 1WMA .

In enzymology, a carbonyl reductase (NADPH) (EC 1.1.1.184) is an enzyme that catalyzes the chemical reaction

R-CO-R' + NADPH + H+ :R-CHOH-R' + NADP+

Thus, the two products of this enzyme are R-CHOH-R' and NADP+, whereas its 3 substrates are R-CO-R', NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is secondary-alcohol:NADP+ oxidoreductase. Other names in common use include aldehyde reductase 1, prostaglandin 9-ketoreductase, xenobiotic ketone reductase, NADPH-dependent carbonyl reductase, ALR3, carbonyl reductase, nonspecific NADPH-dependent carbonyl reductase, aldehyde reductase 1, and carbonyl reductase (NADPH). This enzyme participates in arachidonic acid metabolism, and has recently been shown to catabolize S-Nitrosoglutathione, as a means to degrade NO in an NADPH-dependent manner.

Structural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes 1CYD, 1WMA, 2HRB, and 2PFG.

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References