Cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase

Last updated
cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase
Identifiers
EC no. 1.3.1.29
CAS no. 53986-49-5
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO
Search
PMC articles
PubMed articles
NCBI proteins

In enzymology, cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase (EC 1.3.1.29) is an enzyme that catalyzes the chemical reaction

+ NAD+
 
 
 
H+
Cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase
 
H+
 
1,2-naphthalenediol.svg
1,2-naphthalenediol
+ NADH
 

The two substrates of this enzyme are (1R, 2S)-cis 1,2 dihydroxy-1,2-dihydronaphthalene and oxidised nicotinamide adenine dinucleotide (NAD+). Its products are 1,2-naphthalenediol, reduced NADH, and a proton. [1] [2]

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is cis-1,2-dihydronaphthalene-1,2-diol:NAD+ 1,2-oxidoreductase. Other names in common use include (+)-cis-naphthalene dihydrodiol dehydrogenase, naphthalene dihydrodiol dehydrogenase, and cis-dihydrodiol naphthalene dehydrogenase. This enzyme participates in 1- and 2-methylnaphthalene degradation and naphthalene and anthracene degradation. [1]

References

  1. 1 2 Enzyme 1.3.1.29 at KEGG Pathway Database.
  2. Patel TR, Gibson DT (1974). "Purification and properties of (plus)-cis-naphthalene dihydrodiol dehydrogenase of Pseudomonas putida". J. Bacteriol. 119 (3): 879–88. doi:10.1128/jb.119.3.879-888.1974. PMC   245694 . PMID   4369091.