Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase

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cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase
Identifiers
EC no. 1.3.1.56
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO
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NCBI proteins

In enzymology, cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase (EC 1.3.1.56) is an enzyme that catalyzes the chemical reaction

+ NAD+
 
 
 
H+
Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase
 
H+
 
+ NADH
 

The two substrates of this enzyme are (1S,2R)-3-phenylcyclohexa-3,5-diene-1,2-diol and oxidised nicotinamide adenine dinucleotide (NAD+). Its products are biphenyl-2,3-diol, reduced NADH, and a proton. [1] [2] [3]

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is cis-3-phenylcyclohexa-3,5-diene-1,2-diol:NAD+ oxidoreductase. This enzyme is also called 2,3-dihydro-2,3-dihydroxybiphenyl dehydrogenase. This enzyme participates in biphenyl degradation. [4]

References

  1. Enzyme 1.3.1.56 at KEGG Pathway Database.
  2. Sylvestre M, Hurtubise Y, Barriault D, Bergeron J, Ahmad D (1996). "Characterization of active recombinant 2,3-dihydro-2,3-dihydroxybiphenyl dehydrogenase from Comamonas testosteroni B-356 and sequence of the encoding gene (bphB)". Appl. Environ. Microbiol. 62 (8): 2710–5. Bibcode:1996ApEnM..62.2710S. doi:10.1128/aem.62.8.2710-2715.1996. PMC   168055 . PMID   8702262.
  3. Hofer B, Eltis LD, Dowling DN, Timmis KN (1993). "Genetic analysis of a Pseudomonas locus encoding a pathway for biphenyl/polychlorinated biphenyl degradation". Gene. 130 (1): 47–55. doi:10.1016/0378-1119(93)90345-4. PMID   8344527.
  4. Takagi M, Yano K (1994). "Identification of the bphA and bphB genes of Pseudomonas sp. strains KKS102 involved in degradation of biphenyl and polychlorinated biphenyls". Biochem. Biophys. Res. Commun. 202 (2): 850–6. Bibcode:1994BBRC..202..850F. doi:10.1006/bbrc.1994.2008. PMID   8048958.