Commiphora wightii | |
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Guggul tree in its natural habitat | |
Scientific classification | |
Kingdom: | Plantae |
Clade: | Tracheophytes |
Clade: | Angiosperms |
Clade: | Eudicots |
Clade: | Rosids |
Order: | Sapindales |
Family: | Burseraceae |
Genus: | Commiphora |
Species: | C. wightii |
Binomial name | |
Commiphora wightii | |
Synonyms [2] | |
Commiphora wightii, with common names Indian bdellium-tree, [3] gugal, [4] guggal, guggul, [3] gugul, [3] or mukul myrrh tree, is a flowering plant in the family Burseraceae, which produces a fragrant resin called gugal, guggul or gugul, that is used in incense and vedic medicine (or ayurveda). The species is native to southern Pakistan and western India. It prefers arid and semi-arid climates and is tolerant of poor soil. [1]
Commiphora wightii grows as a shrub or small tree, reaching a maximum height of 4 m (13 ft), with thin papery bark. [4] The branches are thorny. The leaves are simple or trifoliate, the leaflets ovate, 1–5 cm (0.39–1.97 in) long, 0.5–2.5 cm (0.20–0.98 in) broad, and irregularly toothed. It is gynodioecious, with some plants bearing bisexual and male flowers, and others with female flowers. The individual flowers are red to pink, with four small petals. The small round fruit are red when ripe.
Commiphora wightii is sought for its gummy resin, which is harvested from the plant's bark through the process of tapping. In India and Pakistan, guggul is cultivated commercially. The resin of C. wightii, known as gum guggulu, has a fragrance similar to that of myrrh and is commonly used in incense and perfumes. It is the same product that was known in Hebrew, ancient Greek and Latin sources as bdellium.
Guggul is used in Ayurveda remedies and it is mentioned in Ayurvedic texts dating back to 600 BC. [5] It is often sold as a herbal supplement.
The gum can be purchased in a loosely packed form called dhoop, an incense from India, which is burned over hot coals. This produces a fragrant, dense smoke. [6] It is also sold in the form of incense sticks and dhoop cones which can be burned directly.
Over a hundred metabolites of various chemical compositions were reported from the leaves, stem, latex, root and fruit samples. High concentrations of quinic acid and myo-inositol were found in fruits and leaves. [7]
Commiphora wightii has been a key component in ancient Indian Ayurvedic system of medicine.
The extract of gum guggul, called gugulipid, guggulipid, or guglipid, has been used in Unani and Ayurvedic medicine, for nearly 3,000 years in India. [8] [9] One chemical ingredient in the extract is the steroid guggulsterone, [10] which acts as an antagonist of the farnesoid X receptor, once believed to result in decreased cholesterol synthesis in the liver. However, several studies have been published that indicate no overall reduction in total cholesterol occurs using various dosages of guggulsterone and levels of low-density lipoprotein ("bad cholesterol") increased in many people. [11] [12]
Because of its use in traditional medicine, C. wightii has been overharvested, and has become so scarce in its two habitats in India—Gujarat and Rajasthan—that the World Conservation Union (IUCN) has enlisted it in its IUCN Red List of threatened species. [1] Several efforts are in place to address this situation. India's National Medicinal Plants Board launched a project in Kutch District to cultivate 500 to 800 hectares (1,200 to 2,000 acres) of guggal, [13] while a grass-roots conservation movement, led by IUCN associate Vineet Soni, has been started to educate guggal growers and harvesters in safe, sustainable harvesting methods. [14] [15]
In polymer chemistry and materials science, a resin is a solid or highly viscous substance of plant or synthetic origin that is typically convertible into polymers. Resins are usually mixtures of organic compounds. This article focuses mainly on naturally occurring resins.
Myrrh is a gum-resin extracted from a few small, thorny tree species of the Commiphora genus, belonging to the Burseraceae family. Myrrh resin has been used throughout history in medicine, perfumery, and incenses. Myrrh mixed with posca or wine was widely used in many ancient cultures to produce pleasurable feelings and as an anti-inflammatory and analgesic.
Opodeldoc is a medical plaster or liniment invented, or at least named, by the German Renaissance physician Paracelsus in the 1500s. In modern form opodeldoc is a mixture of soap in alcohol, to which camphor and sometimes a number of herbal essences, most notably wormwood, are added.
Frankincense, also known as olibanum, is an aromatic resin used in incense and perfumes, obtained from trees of the genus Boswellia in the family Burseraceae. The word is from Old French franc encens. There are several species of Boswellia that produce true frankincense: Boswellia sacra, B. frereana, B. serrata, and B. papyrifera. Resin from each is available in various grades, which depends on the time of harvesting. The resin is hand-sorted for quality.
Balsam is the resinous exudate which forms on certain kinds of trees and shrubs. Balsam owes its name to the biblical Balm of Gilead.
Onycha, along with equal parts of stacte, galbanum, and frankincense, was one of the components of the consecrated Ketoret (incense) which appears in the Torah book of Exodus (Ex.30:34-36) and was used in Solomon's Temple in Jerusalem. This formula was to be incorporated as an incense, and was not to be duplicated for non-sacred use. What the onycha of antiquity actually was cannot be determined with certainty. The original Hebrew word used for this component of the ketoret was שחלת, shecheleth, which means "to roar; as a lion " or “peeling off by concussion of sound." Shecheleth is related to the Syriac shehelta which is translated as “a tear, distillation, or exudation.” In Aramaic, the root SHCHL signifies “retrieve.” When the Torah was translated into Greek the Greek word “onycha” ονυξ, which means "fingernail" or "claw," was substituted for shecheleth.
Benzoin or benjamin is a balsamic resin obtained from the bark of several species of trees in the genus Styrax. It is used in perfumes and some kinds of incense and as a flavoring and medicine. It is distinct from the chemical compound benzoin, which is ultimately derived chemically from benzoin resin; the primary active ingredient of benzoin resin is actually benzoic acid, not benzoin.
The Burseraceae are a moderate-sized family of 17-19 genera and about 540 species of woody flowering plants. The actual numbers given in taxonomic sources differ according to taxonomic revision at the time of writing. The Burseraceae are also known as the torchwood family, the frankincense and myrrh family, or simply the incense tree family. The family includes both trees and shrubs; its species are native to tropical regions of Africa, Asia, Australasia, and the Americas.
Bdellium is a semi-transparent oleo-gum resin extracted from Commiphora wightii plants, and from Commiphora africana trees growing in sub-saharan Africa. According to Pliny the best quality came from Bactria. Other named sources for the resin are India, Pakistan, Arabia, Media, and Babylon.
The genus of the myrrhs, Commiphora, is the most species-rich genus of flowering plants in the frankincense and myrrh family, Burseraceae. The genus contains approximately 190 species of shrubs and trees, which are distributed throughout the (sub-) tropical regions of Africa, the western Indian Ocean islands, the Arabian Peninsula, India, and South America. The genus is drought-tolerant and common throughout the xerophytic scrub, seasonally dry tropical forests, and woodlands of these regions.
India is the world's main incense producing country, and is also a major exporter to other countries. In India, incense sticks are called Agarbatti (Agar: from Dravidian probably Tamil அகில், அகிர், Sanskrit varti, meaning "stick". An older term "Dhūpavarti" is more commonly used in ancient and medieval texts which encompasses various types of stick incense recipes. Incense is part of the cottage industry in India and important part of many religions in the region since ancient times. The method of incense making with a bamboo stick as a core originated in India at the end of the 19th century, largely replacing the rolled, extruded or shaped method which is still used in India for dhoop.
Guggulsterone is a phytosteroid found in the resin of the guggul plant, Commiphora mukul. Guggulsterone can exist as either of two stereoisomers, E-guggulsterone and Z-guggulsterone. In humans, it acts as an antagonist of the farnesoid X receptor, which was once believed to result in decreased cholesterol synthesis in the liver. Several studies have been published that indicate no overall reduction in total cholesterol occurs using various dosages of guggulsterone, and levels of low-density lipoprotein increased in many people. Nevertheless, guggulsterone is an ingredient in many nutritional supplements. Guggulsterone was also found to have interactions with the viral ADP ribose phosphatase enzyme of SARS-CoV-2 and has been proposed as a potential candidate for the development of therapeutics for the treatment of COVID-19.
Commiphora myrrha, called myrrh, African myrrh, herabol myrrh, Somali myrrhor, common myrrh, is a tree in the Burseraceae family. It is one of the primary trees used in the production of myrrh, a resin made from dried tree sap. The tree is native to the Arabian peninsula and to Africa. It is called 'mur' (المر) in Arabic, meaning bitter. It famously comes from Mecca, so it is called 'Mur Makki'.
Commiphora gileadensis, the Arabian balsam tree, is a shrub species in the genus Commiphora growing in Saudi Arabia, Yemen, southern Oman, Sudan and in southeast Egypt where it may have been introduced. Other common names for the plant include balm of Gilead and Mecca myrrh, but this is due to historical confusion between several plants and the historically important expensive perfumes and drugs obtained from them.
Clerodendrum phlomidis is a species of flowering plant in the family Lamiaceae. The plant has been used in Ayurvedic medicine, and some Ayurvedic sources refer to it by the synonym Clerodendrum multiflorum.
Vineet Soni, the son of noted botanist Professor P.L. Swarnkar, is an Indian plant physiologist, biotechnologist and social activist. He is the founder of the "Save Guggul Movement", a community-based conservation effort to conserve threatened plant species, particularly guggul. Presently, he is the Head at the Department of Botany, Mohanlal Sukhadia University, Udaipur.
Opopanax is the commercial name of bisabol or bissabol, the fragrant oleo-gum-resin of Commiphora guidottii. It has been a major export article from Somalia since ancient times, and is called hebbakhade, habaghadi or habak hadi in Somali. It is an important ingredient in perfumery and therefore known as scented myrrh, sweet myrrh, perfumed myrrh or perfumed bdellium.
Sukh Dev FNA, FASc is an Indian organic chemist, academic, researcher and writer, known for his contributions in the development of Guggulsterone, a plant-derived steroid used as a therapeutic and nutritional agent. He has conducted advanced research in biomedical science and natural products chemistry and holds 55 patents for his findings.
Shyam Swarup Agarwal was an Indian geneticist, immunologist and the director of Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGI-MS), Lucknow. A former director of the Advanced Center for Treatment, Research and Education in Cancer (ACTREC) at the Tata Memorial Centre, he was the pioneer of medical genetics and clinical immunology education in India. Known for his researches in the fields of genetics and molecular biology, he was an Emeritus Professor of the National Academy of Medical Sciences, and an elected fellow of all the three major Indian science academies, namely, the Indian Academy of Sciences, National Academy of Sciences, India, and the Indian National Science Academy. The Council of Scientific and Industrial Research, the apex agency of the Government of India for scientific research, awarded him the Shanti Swarup Bhatnagar Prize for Science and Technology, one of the highest Indian science awards for his contributions to Medical Sciences in 1986.
Polyherbal formulation (PHF) is the use of more than one herb in a herbal medicine preparation. The concept is found in Ayurvedic and other traditional medicinal systems where multiple herbs in a particular ratio may be used in the treatment of illness. It is used in these systems for the treatment of many diseases, including diabetes. The Ayurvedic text Sarangdhar Samhita, dated 1300 CE, has highlighted the concept of polyherbalism in Ayurveda. In the traditional system of Indian medicine, plant formulations and combined extracts of plants are chosen rather than individual ones. Ayurvedic herbal formulations are prepared in a number of dosage forms, in which mostly all of them are PHF. Due to synergism, polyherbalism confers some benefits which is not available in single herbal formulation.