Cyclohexa-1,5-dienecarbonyl-CoA hydratase

cyclohexa-1,5-dienecarbonyl-CoA hydratase
Identifiers
EC no.	4.2.1.100
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The enzyme cyclohexa-1,5-dienecarbonyl-CoA hydratase (EC 4.2.1.100) catalyzes the chemical reaction

6-hydroxycyclohex-1-enecarbonyl-CoA ${\displaystyle \rightleftharpoons }$ cyclohexa-1,5-dienecarbonyl-CoA + H₂O

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is 6-hydroxycyclohex-1-enecarbonyl-CoA (cyclohexa-1,5-dienecarbonyl-CoA-forming). Other names in common use include cyclohexa-1,5-diene-1-carbonyl-CoA hydratase, dienoyl-CoA hydratase, and cyclohexa-1,5-dienecarbonyl-CoA hydro-lyase (incorrect). This enzyme participates in benzoate degradation via CoA ligation.

References

• Laempe D, Eisenreich W, Bacher A, Fuchs G (1998). "Cyclohexa-1,5-diene-1-carbonyl-CoA hydratase [corrected], an enzyme involved in anaerobic metabolism of benzoyl-CoA in the denitrifying bacterium Thauera aromatica". Eur. J. Biochem. 255 (3): 618–27. doi: 10.1046/j.1432-1327.1998.2550618.x . PMID   9738901.
• Harwood CS, Gibson J (1997). "Shedding light on anaerobic benzene ring degradation: a process unique to prokaryotes?". J. Bacteriol. 179 (2): 301–9. PMC   178697 . PMID   8990279.
• Koch J, Eisenreich W, Bacher A, Fuchs G (1993). "Products of enzymatic reduction of benzoyl-CoA, a key reaction in anaerobic aromatic metabolism". Eur. J. Biochem. 211 (3): 649–61. doi: 10.1111/j.1432-1033.1993.tb17593.x . PMID   8436125.