D-xylose reductase

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D-xylose reductase
Identifiers
EC no. 1.1.1.307
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D-xylose reductase (EC 1.1.1.307, XylR, XyrA, msXR, dsXR, monospecific xylose reductase, dual specific xylose reductase, NAD(P)H-dependent xylose reductase, xylose reductase) is an enzyme with systematic name xylitol:NAD(P)+ oxidoreductase. [1] [2] [3] [4] [5] [6] [7] [8] This enzyme catalyses the following chemical reaction

Xylitol-2D-structure.svg
xylitol
+ NAD+
 
 
 
H+
D-xylose reductase
 
H+
 
L-xylose.svg
D-xylose
+ NADH
 

Xylose reductase catalyses the initial reaction in the xylose utilization pathway. The enzyme can use nicotinamide adenine dinucleotide (NADH) or nicotinamide adenine dinucleotide phosphate (NADPH) as its cofactor. [9]

References

  1. ↑ Neuhauser W, Haltrich D, Kulbe KD, Nidetzky B (September 1997). "NAD(P)H-dependent aldose reductase from the xylose-assimilating yeast Candida tenuis. Isolation, characterization and biochemical properties of the enzyme". The Biochemical Journal. 326 ( Pt 3) (Pt 3): 683–92. doi:10.1042/bj3260683. PMC   1218722 . PMID   9307017.
  2. ↑ Nidetzky B, Brüggler K, Kratzer R, Mayr P (December 2003). "Multiple forms of xylose reductase in Candida intermedia: comparison of their functional properties using quantitative structure-activity relationships, steady-state kinetic analysis, and pH studies". Journal of Agricultural and Food Chemistry. 51 (27): 7930–5. doi:10.1021/jf034426j. PMID   14690376.
  3. ↑ Iablochkova EN, Bolotnikova OI, Mikhaĭlova NP, Nemova NN, Ginak AI (2003). "[The activity of xylose reductase and xylitol dehydrogenase in yeasts]". Mikrobiologiia. 72 (4): 466–9. PMID   14526534.
  4. ↑ Chen LC, Huang SC, Chuankhayan P, Chen CD, Huang YC, Jeyakanthan J, Pang HF, Men LC, Chen YC, Wang YK, Liu MY, Wu TK, Chen CJ (April 2009). "Purification, crystallization and preliminary X-ray crystallographic analysis of xylose reductase from Candida tropicalis". Acta Crystallographica Section F. 65 (Pt 4): 419–21. doi:10.1107/S1744309109008719. PMC   2664776 . PMID   19342796.
  5. ↑ Verduyn C, Van Kleef R, Frank J, Schreuder H, Van Dijken JP, Scheffers WA (March 1985). "Properties of the NAD(P)H-dependent xylose reductase from the xylose-fermenting yeast Pichia stipitis". The Biochemical Journal. 226 (3): 669–77. doi:10.1042/bj2260669. PMC   1144764 . PMID   3921014.
  6. ↑ Fernandes S, Tuohy MG, Murray PG (December 2009). "Xylose reductase from the thermophilic fungus Talaromyces emersonii: cloning and heterologous expression of the native gene (Texr) and a double mutant (TexrK271R + N273D) with altered coenzyme specificity". Journal of Biosciences. 34 (6): 881–90. doi:10.1007/s12038-009-0102-7. PMID   20093741. S2CID   23211696.
  7. ↑ Lee JK, Koo BS, Kim SY (October 2003). "Cloning and characterization of the xyl1 gene, encoding an NADH-preferring xylose reductase from Candida parapsilosis, and its functional expression in Candida tropicalis". Applied and Environmental Microbiology. 69 (10): 6179–88. Bibcode:2003ApEnM..69.6179L. doi:10.1128/AEM.69.10.6179-6188.2003. PMC   201247 . PMID   14532079.
  8. ↑ Woodyer R, Simurdiak M, van der Donk WA, Zhao H (March 2005). "Heterologous expression, purification, and characterization of a highly active xylose reductase from Neurospora crassa". Applied and Environmental Microbiology. 71 (3): 1642–7. Bibcode:2005ApEnM..71.1642W. doi:10.1128/AEM.71.3.1642-1647.2005. PMC   1065158 . PMID   15746370.
  9. ↑ Enzyme 1.1.1.307 at KEGG Pathway Database.


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