FGD3

FGD3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2COC
Identifiers
Aliases	FGD3 , ZFYVE5, FYVE, RhoGEF and PH domain containing 3
External IDs	OMIM: 617554; MGI: 1353657; HomoloGene: 22925; GeneCards: FGD3; OMA:FGD3 - orthologs
Gene location (Human) Chr. Chromosome 9 (human) [1] Band 9q22.31 Start 92,947,523 bp [1] End 93,036,236 bp [1]
Gene location (Mouse) Chr. Chromosome 13 (mouse) [2] Band 13 A5|13 25.18 cM Start 49,415,030 bp [2] End 49,473,787 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte blood thymus monocyte spleen bone marrow cells trabecular bone pancreatic ductal cell lymph node appendix Top expressed in granulocyte gastrula yolk sac embryo thymus visual cortex dentate gyrus of hippocampal formation granule cell cerebellar cortex primary visual cortex submandibular gland More reference expression data BioGPS n/a
Gene ontology Molecular function metal ion binding small GTPase binding guanyl-nucleotide exchange factor activity Cellular component cytoplasm cytosol Golgi apparatus ruffle cytoskeleton lamellipodium Biological process regulation of GTPase activity filopodium assembly cytoskeleton organization regulation of cell shape positive regulation of apoptotic process regulation of Rho protein signal transduction regulation of small GTPase mediated signal transduction actin cytoskeleton organization G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 89846 30938 Ensembl ENSG00000127084 ENSMUSG00000037946 UniProt Q5JSP0 O88842 RefSeq (mRNA) NM_001083536 NM_001286993 NM_033086 NM_001369951 NM_001369952 NM_015759 RefSeq (protein) NP_001077005 NP_001273922 NP_149077 NP_001356880 NP_001356881 NP_001077005.1 NP_149077.2 n/a Location (UCSC) Chr 9: 92.95 – 93.04 Mb Chr 13: 49.42 – 49.47 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

FYVE, RhoGEF and PH domain-containing protein 3 is a protein that in humans is encoded by the FGD3 gene. ^{[5] [6]}

See also

• FYVE, RhoGEF and PH domain containing
  • FYVE domain (zinc finger domain)
  • RhoGEF domain (with guanine nucleotide exchange factor activity)
  • PH domain (pleckstrin homology domain)

References

1. GRCh38: Ensembl release 89: ENSG00000127084 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000037946 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hattori A, Okumura K, Nagase T, Kikuno R, Hirosawa M, Ohara O (Feb 2001). "Characterization of long cDNA clones from human adult spleen". DNA Res. 7 (6): 357–66. doi: 10.1093/dnares/7.6.357 . PMID   11214971.
6. "Entrez Gene: FGD3 FYVE, RhoGEF and PH domain containing 3".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Pasteris NG, Nagata K, Hall A, Gorski JL (2000). "Isolation, characterization, and mapping of the mouse Fgd3 gene, a new Faciogenital Dysplasia (FGD1; Aarskog Syndrome) gene homologue". Gene. 242 (1–2): 237–47. doi:10.1016/S0378-1119(99)00518-1. PMID   10721717.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. Bibcode:2004Natur.429..369H. doi:10.1038/nature02465. PMC   2734081 . PMID   15164053.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Delague V, Jacquier A, Hamadouche T, et al. (2007). "Mutations in FGD4 encoding the Rho GDP/GTP exchange factor FRABIN cause autosomal recessive Charcot-Marie-Tooth type 4H". Am. J. Hum. Genet. 81 (1): 1–16. doi:10.1086/518428. PMC   1950914 . PMID   17564959.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human FYVE, RhoGEF and PH domain-containing protein 3 (FGD3)