Geranylgeranyl diphosphate reductase

Last updated
Geranylgeranyl diphosphate reductase
Identifiers
EC no. 1.3.1.83
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Search
PMC articles
PubMed articles
NCBI proteins

Geranylgeranyl diphosphate reductase (EC 1.3.1.83, geranylgeranyl reductase, CHL P) is an enzyme with systematic name geranylgeranyl-diphosphate:NADP+ oxidoreductase. [1] [2] This enzyme catalyses the following chemical reaction

+ 3 NADPH
 
 
3 H+
 
Geranylgeranyl diphosphate reductase
3 H+
 
 
+ 3 NADP+
 

The substrate of this enzyme is geranylgeranyl pyrophosphate, which reacts with three equivalents of reduced nicotinamide adenine dinucleotide phosphate (NADPH), and three protons. The product is phytyl diphosphate and oxidised NADP+. [3] It can also act on geranylgeranyl-chlorophyll a. [4]

References

  1. Soll J, Schultz G, Rüdiger W, Benz J (April 1983). "Hydrogenation of geranylgeraniol : two pathways exist in spinach chloroplasts". Plant Physiology. 71 (4): 849–54. doi:10.1104/pp.71.4.849. PMC   1066133 . PMID   16662918.
  2. Keller Y, Bouvier F, d'Harlingue A, Camara B (January 1998). "Metabolic compartmentation of plastid prenyllipid biosynthesis--evidence for the involvement of a multifunctional geranylgeranyl reductase". European Journal of Biochemistry. 251 (1–2): 413–7. doi: 10.1046/j.1432-1327.1998.2510413.x . PMID   9492312.
  3. Enzyme 1.3.1.83 at KEGG Pathway Database.
  4. Tanaka R, Oster U, Kruse E, Rudiger W, Grimm B (July 1999). "Reduced activity of geranylgeranyl reductase leads to loss of chlorophyll and tocopherol and to partially geranylgeranylated chlorophyll in transgenic tobacco plants expressing antisense RNA for geranylgeranyl reductase". Plant Physiology. 120 (3): 695–704. doi:10.1104/pp.120.3.695. PMC   59307 . PMID   10398704.