Glutathione peroxidase 5

GPX5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2I3Y
Identifiers
Aliases	GPX5 , HEL-S-75p, glutathione peroxidase 5, GPx-5, EGLP, GSHPx-5
External IDs	OMIM: 603435; MGI: 104886; HomoloGene: 1155; GeneCards: GPX5; OMA:GPX5 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6p22.1 Start 28,525,881 bp [1] End 28,534,955 bp [1]
Gene location (Mouse) Chr. Chromosome 13 (mouse) [2] Band 13 A3.1|13 7.73 cM Start 21,470,599 bp [2] End 21,476,901 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right testis left testis superior frontal gyrus prefrontal cortex islet of Langerhans prostate canal of the cervix blood human musculoskeletal system skeletal muscle Top expressed in morula Ileal epithelium blastocyst perirhinal cortex entorhinal cortex dorsal striatum CA3 field white adipose tissue epidermis adrenal gland More reference expression data BioGPS n/a
Gene ontology Molecular function oxidoreductase activity peroxidase activity glutathione peroxidase activity Cellular component sperm plasma membrane extracellular region extracellular space Biological process cellular oxidant detoxification response to oxidative stress lipid metabolism cellular response to oxidative stress Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2880 14780 Ensembl ENSG00000257770 ENSG00000224586 ENSMUSG00000004344 UniProt O75715 P21765 RefSeq (mRNA) NM_001509 NM_003996 NM_010343 RefSeq (protein) NP_001500 NP_003987 NP_034473 Location (UCSC) Chr 6: 28.53 – 28.53 Mb Chr 13: 21.47 – 21.48 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Glutathione peroxidase 5 (GPx-5), also known as epididymal secretory glutathione peroxidase is an enzyme that in humans is encoded by the GPX5 gene. ^{[5] [6]}

GPx-5 belongs to the glutathione peroxidase family. It is specifically expressed in the epididymis in the mammalian male reproductive tract, and is androgen-regulated. Unlike mRNAs for other characterized glutathione peroxidases, this mRNA does not contain a selenocysteine (UGA) codon. Thus, the encoded protein is selenium-independent, and has been proposed to play a role in protecting the membranes of spermatozoa from the damaging effects of lipid peroxidation and/or preventing premature acrosome reaction. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. ^[5]

References

1. ENSG00000224586 GRCh38: Ensembl release 89: ENSG00000257770, ENSG00000224586 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000004344 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: glutathione peroxidase 5 (epididymal androgen-related protein)".
6. Hall L, Williams K, Perry AC, Frayne J, Jury JA (July 1998). "The majority of human glutathione peroxidase type 5 (GPX5) transcripts are incorrectly spliced: implications for the role of GPX5 in the male reproductive tract". Biochem. J. 333 (1): 5–9. doi:10.1042/bj3330005. PMC   1219548 . PMID   9639555.

Further reading

• Talmud PJ, Drenos F, Shah S, et al. (2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". Am. J. Hum. Genet. 85 (5): 628–42. doi:10.1016/j.ajhg.2009.10.014. PMC   2775832 . PMID   19913121.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi: 10.1038/nature02055 . PMID   14574404.
• Perry AC, Jones R, Niang LS, et al. (1992). "Genetic evidence for an androgen-regulated epididymal secretory glutathione peroxidase whose transcript does not contain a selenocysteine codon". Biochem. J. 285 (3): 863–70. doi:10.1042/bj2850863. PMC   1132876 . PMID   1386734.
• Richard MJ, Guiraud P, Didier C, et al. (2001). "Human immunodeficiency virus type 1 Tat protein impairs selenoglutathione peroxidase expression and activity by a mechanism independent of cellular selenium uptake: consequences on cellular resistance to UV-A radiation". Arch. Biochem. Biophys. 386 (2): 213–20. doi:10.1006/abbi.2000.2197. PMID   11368344.
• Opalenik SR, Ding Q, Mallery SR, Thompson JA (1998). "Glutathione depletion associated with the HIV-1 TAT protein mediates the extracellular appearance of acidic fibroblast growth factor". Arch. Biochem. Biophys. 351 (1): 17–26. doi:10.1006/abbi.1997.0566. PMID   9501919.
• Hartley JL, Temple GF, Brasch MA (2000). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Rejraji H, Vernet P, Drevet JR (2002). "GPX5 is present in the mouse caput and cauda epididymidis lumen at three different locations". Mol. Reprod. Dev. 63 (1): 96–103. doi:10.1002/mrd.10136. PMID   12211066. S2CID   8103049.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Choi J, Liu RM, Kundu RK, et al. (2000). "Molecular mechanism of decreased glutathione content in human immunodeficiency virus type 1 Tat-transgenic mice". J. Biol. Chem. 275 (5): 3693–8. doi: 10.1074/jbc.275.5.3693 . PMID   10652368.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Vernet P, Faure J, Dufaure JP, Drevet JR (1997). "Tissue and developmental distribution, dependence upon testicular factors and attachment to spermatozoa of GPX5, a murine epididymis-specific glutathione peroxidase". Mol. Reprod. Dev. 47 (1): 87–98. doi:10.1002/(SICI)1098-2795(199705)47:1<87::AID-MRD12>3.0.CO;2-X. PMID   9110319. S2CID   20995200.
• Price TO, Ercal N, Nakaoke R, Banks WA (2005). "HIV-1 viral proteins gp120 and Tat induce oxidative stress in brain endothelial cells". Brain Res. 1045 (1–2): 57–63. doi:10.1016/j.brainres.2005.03.031. PMID   15910762. S2CID   7362454.
• Williams K, Frayne J, Hall L (1998). "Expression of extracellular glutathione peroxidase type 5 (GPX5) in the rat male reproductive tract". Mol. Hum. Reprod. 4 (9): 841–8. doi: 10.1093/molehr/4.9.841 . PMID   9783843.
• Bailey SD, Xie C, Do R, et al. (2010). "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study". Diabetes Care. 33 (10): 2250–3. doi:10.2337/dc10-0452. PMC   2945168 . PMID   20628086.
• Moyer AM, Sun Z, Batzler AJ, et al. (2010). "Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy". Cancer Epidemiol. Biomarkers Prev. 19 (3): 811–21. doi:10.1158/1055-9965.EPI-09-0871. PMC   2837367 . PMID   20200426.