Glycylpeptide N-tetradecanoyltransferase 1

NMT1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1RXT, 3IU1, 3IU2, 3IWE, 3JTK, 4C2Y, 4C2Z
Identifiers
Aliases	NMT1 , Nmt1, AW536594, NMT, N-myristoyltransferase 1
External IDs	OMIM: 160993; MGI: 102579; HomoloGene: 69027; GeneCards: NMT1; OMA:NMT1 - orthologs
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17q21.31 Start 44,957,992 bp [1] End 45,109,016 bp [1]
Gene location (Mouse) Chr. Chromosome 11 (mouse) [2] Band 11|11 E1 Start 102,919,016 bp [2] End 102,959,738 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte right adrenal gland islet of Langerhans sural nerve gastrocnemius muscle left adrenal gland right adrenal cortex Achilles tendon left adrenal cortex granulocyte Top expressed in Ileal epithelium endothelial cell of lymphatic vessel vestibular membrane of cochlear duct Paneth cell primitive streak lacrimal gland gastrula decidua interventricular septum hair follicle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity acyltransferase activity glycylpeptide N-tetradecanoyltransferase activity myristoyltransferase activity Cellular component membrane plasma membrane extrinsic component of membrane cytoplasm mitochondrion cytosol Biological process regulation of rhodopsin mediated signaling pathway in utero embryonic development positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway N-terminal peptidyl-glycine N-myristoylation N-terminal protein myristoylation cellular ketone metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4836 18107 Ensembl ENSG00000136448 ENSMUSG00000020936 UniProt P30419 O70310 RefSeq (mRNA) NM_021079 NM_008707 RefSeq (protein) NP_066565 NP_032733 Location (UCSC) Chr 17: 44.96 – 45.11 Mb Chr 11: 102.92 – 102.96 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Glycylpeptide N-tetradecanoyltransferase 1 also known as myristoyl-CoA:protein N-myristoyltransferase 1 (NMT-1) is an enzyme that in humans is encoded by the NMT1 gene. ^{[5] [6]} It belongs to the protein N-terminal methyltransferase and glycylpeptide N-tetradecanoyltransferase family of enzymes. This enzyme can be inhibited by NMT inhibitors.

References

1. GRCh38: Ensembl release 89: ENSG00000136448 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020936 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Duronio RJ, Reed SI, Gordon JI (May 1992). "Mutations of human myristoyl-CoA:protein N-myristoyltransferase cause temperature-sensitive myristic acid auxotrophy in Saccharomyces cerevisiae". Proc Natl Acad Sci U S A. 89 (9): 4129–33. Bibcode:1992PNAS...89.4129D. doi: 10.1073/pnas.89.9.4129 . PMC   525646 . PMID   1570339.
6. "Entrez Gene: NMT1 N-myristoyltransferase 1".

Further reading

• Rajala RV, Datla RS, Moyana TN, et al. (2000). "N-myristoyltransferase". Mol. Cell. Biochem. 204 (1–2): 135–55. doi:10.1023/A:1007012622030. PMID   10718634. S2CID   264010084.
• Geyer M, Fackler OT, Peterlin BM (2001). "Structure--function relationships in HIV-1 Nef". EMBO Rep. 2 (7): 580–5. doi:10.1093/embo-reports/kve141. PMC   1083955 . PMID   11463741.
• Wice BM, Gordon JI (1992). "A strategy for isolation of cDNAs encoding proteins affecting human intestinal epithelial cell growth and differentiation: characterization of a novel gut-specific N-myristoylated annexin". J. Cell Biol. 116 (2): 405–22. doi:10.1083/jcb.116.2.405. PMC   2289284 . PMID   1530946.
• Mumby SM, Heukeroth RO, Gordon JI, Gilman AG (1990). "G-protein alpha-subunit expression, myristoylation, and membrane association in COS cells". Proc. Natl. Acad. Sci. U.S.A. 87 (2): 728–32. Bibcode:1990PNAS...87..728M. doi: 10.1073/pnas.87.2.728 . PMC   53339 . PMID   2153964.
• Pal R, Reitz MS, Tschachler E, et al. (1990). "Myristoylation of gag proteins of HIV-1 plays an important role in virus assembly". AIDS Res. Hum. Retroviruses. 6 (6): 721–30. doi:10.1089/aid.1990.6.721. PMID   2194551.
• Bryant M, Ratner L (1990). "Myristoylation-dependent replication and assembly of human immunodeficiency virus 1". Proc. Natl. Acad. Sci. U.S.A. 87 (2): 523–7. Bibcode:1990PNAS...87..523B. doi: 10.1073/pnas.87.2.523 . PMC   53297 . PMID   2405382.
• Tashiro A, Shoji S, Kubota Y (1990). "Antimyristoylation of the gag proteins in the human immunodeficiency virus-infected cells with N-myristoyl glycinal diethylacetal resulted in inhibition of virus production". Biochem. Biophys. Res. Commun. 165 (3): 1145–54. doi:10.1016/0006-291X(89)92722-8. PMID   2692561.
• Goddard C, Aquino A, Glazer RI, Felsted RL (1989). "Chemical characterization of p17gag from human immunodeficiency virus as an N-terminally myristoylated protein". Eur. J. Biochem. 182 (2): 323–6. doi:10.1111/j.1432-1033.1989.tb14833.x. PMID   2737204.
• Göttlinger HG, Sodroski JG, Haseltine WA (1989). "Role of capsid precursor processing and myristoylation in morphogenesis and infectivity of human immunodeficiency virus type 1". Proc. Natl. Acad. Sci. U.S.A. 86 (15): 5781–5. Bibcode:1989PNAS...86.5781G. doi: 10.1073/pnas.86.15.5781 . PMC   297714 . PMID   2788277.
• Schultz AM, Henderson LE, Oroszlan S, et al. (1985). "Amino terminal myristylation of the protein kinase p60src, a retroviral transforming protein". Science. 227 (4685): 427–9. Bibcode:1985Sci...227..427S. doi:10.1126/science.3917576. PMID   3917576.
• Liu J, Sessa WC (1994). "Identification of covalently bound amino-terminal myristic acid in endothelial nitric oxide synthase". J. Biol. Chem. 269 (16): 11691–4. doi: 10.1016/S0021-9258(17)32626-1 . PMID   7512951.
• Lee PP, Linial ML (1994). "Efficient particle formation can occur if the matrix domain of human immunodeficiency virus type 1 Gag is substituted by a myristylation signal". J. Virol. 68 (10): 6644–54. doi:10.1128/JVI.68.10.6644-6654.1994. PMC   237085 . PMID   7521919.
• Sigal CT, Zhou W, Buser CA, et al. (1995). "Amino-terminal basic residues of Src mediate membrane binding through electrostatic interaction with acidic phospholipids". Proc. Natl. Acad. Sci. U.S.A. 91 (25): 12253–7. doi: 10.1073/pnas.91.25.12253 . PMC   45415 . PMID   7527558.
• Zhou W, Parent LJ, Wills JW, Resh MD (1994). "Identification of a membrane-binding domain within the amino-terminal region of human immunodeficiency virus type 1 Gag protein which interacts with acidic phospholipids". J. Virol. 68 (4): 2556–69. doi:10.1128/JVI.68.4.2556-2569.1994. PMC   236733 . PMID   8139035.
• Kobayashi M, Takamatsu K, Saitoh S, Noguchi T (1993). "Myristoylation of hippocalcin is linked to its calcium-dependent membrane association properties". J. Biol. Chem. 268 (25): 18898–904. doi: 10.1016/S0021-9258(17)46711-1 . PMID   8360179.
• Morikawa Y, Hinata S, Tomoda H, et al. (1996). "Complete inhibition of human immunodeficiency virus Gag myristoylation is necessary for inhibition of particle budding". J. Biol. Chem. 271 (5): 2868–73. doi: 10.1074/jbc.271.5.2868 . PMID   8576268.
• Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID   8619474.
• Zhou W, Resh MD (1997). "Differential membrane binding of the human immunodeficiency virus type 1 matrix protein". J. Virol. 70 (12): 8540–8. doi:10.1128/JVI.70.12.8540-8548.1996. PMC   190946 . PMID   8970978.
• Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC   139146 . PMID   9110174.

See also

• Myristoylation
• N-myristoyltransferase 2

External links

• Overview of all the structural information available in the PDB for UniProt : P30419 (Glycylpeptide N-tetradecanoyltransferase 1) at the PDBe-KB .