| Haplogroup NO1 | |
|---|---|
 | |
| Possible time of origin | Formed circa 45,400–45,840 years BP (NO/NO1, based on YFull 2017, [1] and previous estimates of: 41,500 [95% CI 37,400 <-> 45,600] years BP, [2] 48,871 [95% CI 37,095 <-> 58,831] years BP, [3] and 50,800 or 43,500 years BP [4] ) |
| Coalescence age | Circa 41,500 – 40,067 years BP (NO/NO1, based on YFull 2017, [1] and previous estimates of: 36,800 [95% CI 34,300 <-> 39,300] years BP, [2] 41,900 [31,294 <-> 51,202] years BP, [3] and 44,700 or 38,300 years BP depending on mutation rate [4] ) |
| Possible place of origin | Southeast Asia or East Asia (Northern China) [5] [4] [6] |
| Ancestor | K-M2313 (M2313/Z4858) |
| Descendants | N (M231) and O (M175). [7] |
| Defining mutations | M214/Page39; F176/M2314; CTS5858/M2325/F346; CTS11572 [1] [4] |
Haplogroup NO1 (M214/Page39; F176/M2314; CTS5858/M2325/F346; CTS11572), [7] also known as NO-M214, [7] is a human Y-chromosome DNA haplogroup. NO1 is the sole confirmed subclade of Haplogroup K- M2313 (a.k.a. NO-M2313, K2a1), [8] which is the sole subclade of Haplogroup K2a (K-M2308). [4] NO is the dominant Y-DNA haplogroup in most parts of eastern and northern Eurasia, including East Asia, Siberia and northern Fennoscandia.
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The location of NO1 at the SNP M214 follows the taxonomy set out by Karmin et al. 2022, [8] and conforms to a structure shown by ISOGG (2022). [7] (However neither Karmin nor ISOGG has integrated one of the findings of Poznik et al. 2016: [4] that there was a subclade generation both above haplogroup NO1 (M214) and beneath K-M2308. That is, both ISOGG and Karmin et al. continued to equate K2a with haplogroup NO.)
Before 2016, the subclades compromising both NO and NO1 were not recognised, and were regarded as synonymous with K2a. [4] Researchers such as David Poznik (Poznik et al. 2016) documented examples of previously unknown subclades of haplogroup K2, in both ancient remains and living individuals, which: (firstly) had several, varying suites of the SNPs regarded previously as uniquely defining K2a and NO, but also (secondly) lacked any of the SNPs specifically identifying haplogroups Haplogroup N (M231) and Haplogroup O (M175). [4] This demonstrated conclusively that multiple stages of development separated K2a from NO, which therefore constituted "grandparent" and "grandchild" clades. Poznik et al. 2016 used the name "K2a1" (a.k.a. K-M2313) for the Y-DNA of some of the individuals who belonged to K2a(xK2a*,NO), while also mentioning that K-M2313 did not include all examples of K2a(xK2a*,NO).
As of 2022, the International Society of Genetic Genealogy (ISOGG) refers to NO-M214 as "NO1", and to K2a (M2308)/K-M2313 as "NO". [7] There may be at least one other primary branch of NO: the ISOGG official Y-DNA haplogroup tree lists a haplogroup known as "NO1~" [ sic ] (CTS707/M2306) alongside NO-M214 (which ISOGG refers to as "NO1"). [7] The tilde (~) indicates that its exact position of NO1~ in the phylogeny is unknown. It may be a primary branch or sibling of NO, it may be a primary branch or sibling of K2a, K-M2313, or it may instead be a primary branch of K2a.
Based on the projected origins of K2a, K-M2313, and the basal haplogroups N* and O* respectively, NO* probably originated in East Asia. [5] [4]
