L-galactose 1-dehydrogenase

L-galactose 1-dehydrogenase
Identifiers
EC no.	1.1.1.316
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

L-galactose 1-dehydrogenase (EC 1.1.1.316, L-GalDH, L-galactose dehydrogenase) is an enzyme with the systematic name L-galactose:NAD⁺ 1-oxidoreductase. ^{[1] [2] [3] [4]} This enzyme catalyses the following chemical reaction: ^[5]

L-galactopyranose

+ NAD⁺

 

 

 

H⁺

 

H⁺

 

L-galactono-1,4-lactone

+ NADH

 

The enzyme catalyses a step in the ascorbate biosynthesis in higher plants.

References

1. Mieda T, Yabuta Y, Rapolu M, Motoki T, Takeda T, Yoshimura K, Ishikawa T, Shigeoka S (September 2004). "Feedback inhibition of spinach L-galactose dehydrogenase by L-ascorbate". Plant & Cell Physiology. 45 (9): 1271–9. doi: 10.1093/pcp/pch152 . PMID   15509850.
2. Gatzek S, Wheeler GL, Smirnoff N (June 2002). "Antisense suppression of l-galactose dehydrogenase in Arabidopsis thaliana provides evidence for its role in ascorbate synthesis and reveals light modulated l-galactose synthesis". The Plant Journal. 30 (5): 541–53. doi: 10.1046/j.1365-313x.2002.01315.x . PMID   12047629.
3. Wheeler GL, Jones MA, Smirnoff N (May 1998). "The biosynthetic pathway of vitamin C in higher plants". Nature. 393 (6683): 365–9. Bibcode:1998Natur.393..365W. doi:10.1038/30728. PMID   9620799.
4. Oh MM, Carey EE, Rajashekar CB (July 2009). "Environmental stresses induce health-promoting phytochemicals in lettuce". Plant Physiology and Biochemistry. 47 (7): 578–83. Bibcode:2009PlPB...47..578O. doi:10.1016/j.plaphy.2009.02.008. PMID   19297184.
5. Enzyme 1.1.1.316 at KEGG Pathway Database.

External links

• L-galactose+1-dehydrogenase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)