Leonotis nepetifolia

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Leonotis nepetifolia
Leonotis leonorus1.jpg
Scientific classification OOjs UI icon edit-ltr.svg
Kingdom: Plantae
Clade: Tracheophytes
Clade: Angiosperms
Clade: Eudicots
Clade: Asterids
Order: Lamiales
Family: Lamiaceae
Genus: Leonotis
Species:
L. nepetifolia
Binomial name
Leonotis nepetifolia

Leonotis nepetifolia, (also known as klip dagga, Christmas candlestick, or lion's ear [1] ), is a species of plant in the genus Leonotis and the family Lamiaceae (mint), It is native to tropical Africa and southern India. It can also be found growing abundantly in much of Latin America, the West Indies, [2] and the Southeastern United States. [3] It grows to a height of 3 metres (9 ft 10 in) and has whorls of striking lipped flowers, that are most commonly orange, [1] but can vary to red, white, and purple. It has drooping dark green, very soft serrated leaves that can grow up to 10 centimetres (4 in) wide. [1] Sunbirds and ants are attracted to the flowers. [1] It has been found growing on roadsides, rubbish heaps or waste land. [1]

Contents

L. nepetifolia is considered an invasive plant in Australia, Florida, and Hawaii, though its tendency to grow in disturbed areas led researchers in Hawaii to conclude it's not likely to be an ecological threat. [4]

Varieties
  1. Leonotis nepetifolia var. africana(P.Beauv.) J.K.Morton - Indian Subcontinent, much of Africa (light orange flowers)
  2. Leonotis nepetifolia var. nepetifolia - much of Africa (dark solid orange flowers)
  3. Leonotis nepetifolia var. alba - (albino/white flowers)

Leonotis nepetifolia (klip dagga) is related to L. leonurus (wild dagga or lion's tail.) The most noticeable difference between the two is the leaf shape. L. nepetifolia leaves are cordate with serrated edges, except the top pair which are lanceolate with serrated edges, as pictured in taxonomy box. The leaves are all lanceolate with serrated edges on L. leonurus.

Traditional medicine

Leonotis nepetifolia is known in Trinidad as shandilay and the leaves are brewed as a tea for fever, coughs, womb prolapse, malaria, and suggested to be beneficial to bone and lung health. The roots of L. nepetifolia are considered to be the botanical sources of granthiparna, an ayurvedic herb.[ citation needed ]

Phytochemicals and Pharmacology

Leonotis nepetifolia and wild dagga contains several labdane diterpenes including Hydroxynepetaefolin, Nepetaefuran, Nepetaefolinol, Nepetaefolin, Leonotinin, Leonotin and Dubiin as well as bis-spirolabdane diterpenes like Leonepetaefolin A-E. [5] [6] [7]

Methanol based extracts of Leonotis nepetifolia has shown antidepressant-like effects in mice. Metabolic screening of the extract suggested nepetaefolin, methoxynepataefolin, and 7-O-β-glucoside luteolin are the main products. [8]

Nepetaefuran and leonotinin isolated from Leonotis nepetaefolia plant material demonstrated anti-inflammatory by suppressing NF-κB activation related to proinflammatory Cytokines. [9]

Related Research Articles

<i>Leonotis</i> Genus of flowering plants

Leonotis is a genus of flowering plants in the family Lamiaceae. One species, Leonotis nepetifolia, is native to tropical Africa and southern India. It is naturalized throughout most of the tropics. The other species are endemic to southern + eastern Africa.

<i>Allamanda</i> Genus

Allamanda is a genus of flowering plants in the family Apocynaceae. They are native to the Americas, where they are distributed from Mexico to Argentina. Some species are familiar as ornamental plants cultivated for their large, colorful flowers. Most species produce yellow flowers; A. blanchetii bears pink flowers. The genus name Allamanda honors the Swiss botanist and physician Frédéric-Louis Allamand (1736–1809). It is the official flower of Kuching North City Hall.

<i>Euphorbia helioscopia</i> Species of flowering plant

Euphorbia helioscopia, the sun spurge or madwoman's milk, is a species of flowering plant in the spurge family Euphorbiaceae. It is a herbaceous annual plant, native to most of Europe, northern Africa, and eastward through most of Asia.

<i>Leonurus cardiaca</i> Species of plant

Leonurus cardiaca, known as motherwort, is an herbaceous perennial plant in the mint family, Lamiaceae. Other common names include throw-wort, lion's ear, and lion's tail. Lion's tail is also a common name for Leonotis leonurus, and lion's ear, a common name for Leonotis nepetifolia. Originally from Central Asia and southeastern Europe, it is now found worldwide, spread largely due to its use as a herbal remedy.

<i>Sagittaria sagittifolia</i> Species of flowering plant in the family Alismataceae

Sagittaria sagittifolia is a flowering plant in the family Alismataceae, native to wetlands in most of Europe from Ireland and Portugal to Finland and Bulgaria, and in Russia, Ukraine, Siberia, Japan, Turkey, China, India, Australia, Vietnam and the Caucasus. It is also cultivated as a food crop in some other countries. In Britain it is the only native Sagittaria.

<i>Leonotis leonurus</i> Species of plant

Leonotis leonurus, also known as lion's tail and wild dagga, is a plant species in the mint family, Lamiaceae. The plant is a broadleaf evergreen large shrub native to South Africa, where it is very common. It is known for its medicinal properties. The main psychoactive component of Leonotis leonurus is hypothesized to be related to the presence of leonurine or labdanes, Leonotis leonurus has been confirmed to contain Leonurine according to peer reviewed journal published phytochemical analysis. Like other plants in the mint family, it also contains marrubiin. The word "dagga" comes from Afrikaans, and derives in turn from the Khoikhoi "dachab". The word "dagga" has been extended to include cannabis in Afrikaans and South African English, so the use of "wild" serves to distinguish Leonotis leonuris from this.

<i>Banksia armata</i> Species of shrub in the family Proteaceae endemic to Western Australia

Banksia armata, commonly known as prickly dryandra, is a species of often sprawling shrub that is endemic to Western Australia. It has deeply serrated leaves with sharply pointed lobes and spikes of about 45 to 70 yellow flowers.

<i>Banksia tenuis</i> Species of shrub in the family Proteaceae endemic to Western Australia

Banksia tenuis is a species of shrub that is endemic to the southwest of Western Australia. It has pinnatifid, serrated or smooth-edges leaves, golden brown and cream-coloured flowers in heads of about fifty-five and glabrous, egg-shaped follicles.

<span class="mw-page-title-main">Andrographolide</span> Chemical compound

Andrographolide is a labdane diterpenoid that has been isolated from the stem and leaves of Andrographis paniculata. Andrographolide is an extremely bitter substance.

<i>Salvia dorrii</i> Species of shrub

Salvia dorrii, the purple sage, Dorr's sage, fleshy sage, mint sage, or tobacco sage, is a perennial spreading shrub in the family Lamiaceae. It is native to mountain areas in the western United States and northwestern Arizona, found mainly in the Great Basin and southward to the Mojave Desert, growing in dry, well draining soils.

<span class="mw-page-title-main">Ferruginol</span> Chemical compound

Ferruginol is a natural phenol with a terpenoid substructure. Specifically, it is a diterpene of the abietane chemical class, meaning it is characterized by three fused six-membered rings and alkyl functional groups. Ferruginol was first identified in 1939 by Brandt and Neubauer as the main component in the resin of the Miro tree and has since been isolated from other conifer species in the families Cupressaceae and Podocarpaceae. As a biomarker, the presence of ferruginol in fossils, mainly resin, is used to describe the density of these conifers in that particular biosphere throughout time.

<i>Arbutus xalapensis</i> Species of flowering plant

Arbutus xalapensis, commonly known as the Texas madrone, Amazaquitl, or Texas madroño, is a species of flowering plant in the heather family. It is native to Central America, the southwestern United States, and throughout Mexico. It is found in canyons and mountains, on rocky plains, and in oak woodlands, at altitudes of up to 3,000 m in the south of the range, but lower, down to 600 m in the north of the range.

Clerodane diterpenes, sometimes referred to as clerodane diterpenoids, are a large group of secondary metabolites that have been isolated from several hundreds of different plant species, as well as fungi, bacteria and marine sponges. They are bicyclic terpenes that contain 20 carbons and a decalin core.

<i>Acalypha rhomboidea</i> Species of flowering plant

Acalypha rhomboidea is a plant in the spurge family, Euphorbiaceae.

<i>Croton eluteria</i> Species of flowering plant

Croton eluteria, known as cascarilla, is a plant species of the genus Croton that is native to the Caribbean. It has been naturalized in other tropical regions of the Americas. It grows to be a small tree or tall shrub, rarely reaching 20 feet (6 m) in height. Its leaves are scanty, alternate, ovate-lanceolate, averaging 2 inches (5 cm) long, with close scaling below, giving a metallic silver-bronze appearance, and scattered white scales above. The flowers are small, with white petals, and very fragrant, appearing in March and April. The scented bark is fissured, pale yellowish brown, and may be covered in lichen.

<i>Salvia polystachya</i> Species of flowering plant

Salvia polystachya is a herbaceous perennial native to central Mexico and south into Guatemala and Panama, typically growing at elevations from 5,000 to 10,000 feet in mild climates where there is some summer rain. It one of the species used as chia and it is rarely seen in horticulture.

<span class="mw-page-title-main">Docosatetraenoylethanolamide</span> Chemical compound

Docosatetraenoylethanolamide (DEA) (Adrenoyl-ethanolamide) (Adrenoyl-EA) is an endogenous ethanolamide that has been shown to act on the cannabinoid (CB1) receptor. DEA is similar in structure to anandamide (AEA, a recognized endogenous ligand for the CB1 receptor), containing docosatetraenoic acid in place of arachidonic acid. While DEA has been shown to bind to the CB1 receptor with similar potency and efficacy as AEA, its role as a cannabinergic neurotransmitter is not well understood.

<span class="mw-page-title-main">Panicudine</span> Chemical compound

Panicudine (6-hydroxy-11-deoxy-13-dehydrohetisane) is a C20-diterpene alkaloid of the hetisine type, first isolated from Aconitum paniculatum. It has empirical formula C20H25NO3 and a melting point of 249–250 °C. The structure was determined to be a hetisine type diterpene by noting infrared spectrum absorption bands of 3405 cm−1 (OH), 1718 (C=O), and 1650 (C=C), a proton magnetic resonance spectrum with "secondary hydroxy (4.02 ppm, m, 1H, W1/2 = 10 Hz), exomethylene (4.87 and 4.76 ppm, br.s, 1H each), and tertiary methyl (1.29 ppm, s, 3H) groups and the absence of N-methyl, N-ethyl, and methoxy groups." Additional ultraviolet spectrum and carbon-13 NMR data, confirmed by high resolution mass spectrometry, completed the determination of the structure.

<span class="mw-page-title-main">Sugiol</span> Chemical compound

Sugiol is a phenolic abietane derivative of ferruginol and can be used as a biomarker for specific families of conifers. The presence of sugiol can be used to identify the Cupressaceae s.1., podocarpaceae, and Araucaraiaceae families of conifers. The polar terpenoids are among the most resistant molecules to degradation besides n-alkanes and fatty acids, affording them high viability as biomarkers due to their longevity in the sedimentary record. Significant amounts of sugiol has been detected in fossil wood dated to the Eocene and Miocene periods, as well as a sample of Protopodocarpoxylon dated to the middle Jurassic.

References

  1. 1 2 3 4 5 Napier, E. "NOTES· ON WILD FLOWERS" (PDF). biodiversitylibrary.org. Retrieved 31 December 2017.
  2. Kew World Checklist of Selected Plant Families
  3. "Plants Profile for Leonotis nepetifolia (Christmas candlestick)". plants.usda.gov. Retrieved 2021-03-10.
  4. "Leonotis nepetifolia (Christmas candelstick)". CABI Invasive Species Compendium. November 22, 2019. Retrieved March 10, 2021.
  5. Li, Jun; Fronczek, Frank R.; Ferreira, Daneel; Burandt, Charles L.; Setola, Vincent; Roth, Bryan L.; Zjawiony, Jordan K. (27 April 2012). "Bis-spirolabdane Diterpenoids from Leonotis nepetaefolia". Journal of Natural Products. 75 (4): 728–734. doi:10.1021/np3000156. PMC   3338874 . PMID   22475308.
  6. Blount, John F.; Manchand, Percy S. (1 January 1980). "X-Ray structure determination of methoxynepetaefolin and nepetaefolinol, labdane diterpenoids from Leonotis nepetaefolia R.Br". Journal of the Chemical Society, Perkin Transactions 1: 264–268. doi:10.1039/P19800000264.
  7. Barbosa, Jackson de Menezes; Cavalcante, Noelly Bastos; Delange, David Marrero; Almeida, Jackson Roberto Guedes da Silva (2018). "A review of the chemical composition and biological activity of Leonotis nepetifolia (Linn.) R. Br.(lion's ear)". Revista Cubana de Plantas Medicinales. 23 (4). Archived from the original on 6 June 2019.
  8. Arrieta-Báez, Daniel; Gómez-Patiño, Mayra Beatriz; Jurado Hernández, Noé; Mayagoitia-Novales, Lilian; Dorantes-Barrón, Ana María; Estrada-Reyes, Rosa (31 March 2022). "Antidepressant-like effects of a methanol extract of Leonotis nepetifolia in mice". Natural Product Research. 36 (23): 6170–6176. doi:10.1080/14786419.2022.2058939. PMID   35357257. S2CID   247842622.
  9. Ueda, Fumihito; Iizuka, Keito; Tago, Kenji; Narukawa, Yuji; Kiuchi, Fumiyuki; Kasahara, Tadashi; Tamura, Hiroomi; Funakoshi-Tago, Megumi (1 October 2015). "Nepetaefuran and leonotinin isolated from Leonotis nepetaefolia R. Br. potently inhibit the LPS signaling pathway by suppressing the transactivation of NF-κB". International Immunopharmacology. 28 (2): 967–976. doi:10.1016/j.intimp.2015.08.015. PMID   26319953.