| United States Numbered Highways of the Wisconsin State Trunk Highway System | |
|---|---|
   Highway markers used in Wisconsin | |
| System information | |
| Formed | November 11, 1926 [1] |
| Highway names | |
| US Highways | US Highway nn (US nn) |
| Special Routes: | Alternate US Highway nn (Alt. US nn); Business US Highway nn (Bus. US nn); ContentsUS nn); |
| System links | |
US Highways in Wisconsin are 14 current and 3 former United States Numbered Highways in Wisconsin.
| Number | Length (mi) | Length (km) | Southern or western terminus | Northern or eastern terminus | Formed | Removed | Notes | |
|---|---|---|---|---|---|---|---|---|
 US 2 | 104.49 | 168.16 | US 2 in Superior | US 2 in Hurley | 1926 | current | Western segment | |
| US 2 | 14.46 | 23.27 | US 2/US 141 near Florence | US 2/US 141 near Spread Eagle | 1926 | current | Eastern segment, concurrent with US 141 | |
 US 8 | 255.55 | 411.27 | US 8 in St. Croix Falls | US 8 at Norway, MI | 1926 | current | ||
 US 10 | 294.01 | 473.16 | US 10 in Prescott | SS Badger at Manitowoc | 1926 | current | Connects to US 10 in Michigan via car ferry | |
 US 12 | 339.40 | 546.21 | I-94/US 12 in Hudson | US 12 in Genoa City | 1926 | current | ||
 US 14 | 198.49 | 319.44 | US 14/US 61/MN 16 in La Crosse | US 14 in Walworth | 1926 | current | ||
 US 16 | 212.2 | 341.5 | US 14/US 16/US 61 in La Crosse | SS Milwaukee Clipper at Milwaukee | 1926 | 1979 | Connected to US 16 in Michigan via car ferry. Replaced by WIS 16, I-90, and I-94. | |
 US 18 | 182.16 | 293.16 | US 18 in Prairie du Chien | Lincoln Memorial Drive in Milwaukee | 1926 | current | ||
 US 41 | 300 | 480 | I-94/US 41 at Russell, IL | US 41 in Marinette | 1926 | current | Milwaukee–Green Bay segment upgraded to I-41 | |
 US 45 | 305 | 491 | US 45 in Bristol | US 45 near Land O' Lakes | c. 1935 | current | ||
 US 51 | 316.51 | 509.37 | I-39/I-90/US 51 in Beloit | US 2 in Hurley | 1926 | current | ||
 US 53 | 239 | 385 | US 14/US 61/WIS 16 in La Crosse | I-535/US 53 at Duluth, MN | 1926 | current | ||
 US 61 | 120 | 190 | US 61/US 151 in Kieler | US 14/US 61/MN 16 in La Crosse | 1926 | current | ||
 US 63 | 182 | 293 | US 63 in Hager City | US 2 near Benoit | 1926 | current | ||
 US 110 | 37.4 | 60.2 | Oshkosh | Fremont | 1926 | 1936 | Replaced by WIS 110 | |
 US 118 | 38.1 | 61.3 | US 61 in Dickeyville | US 18 in Dodgeville | 1926 | 1928 | ||
 US 141 | 102.87 | 165.55 | I-43 in Bellevue, Wisconsin | US 2/US 141 at Quinnesec, MI | 1926 | current | Southern segment | |
| US 141 | 14.46 | 23.27 | US 2/US 141 near Spread Eagle | US 2/US 141 near Florence | 1928 | current | Northern segment, concurrent with US 2 | |
 US 151 | 337 | 542 | US 61/US 151 in Kieler | US 10 in Manitowoc | 1926 | current | ||
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Except were indicated, the following highways are or were locally maintained.
| Number | Length (mi) | Length (km) | Southern or western terminus | Northern or eastern terminus | Formed | Removed | Notes | |
|---|---|---|---|---|---|---|---|---|
 Bus. US 2 | — | — | — | — | — | — | Formerly served Hurley | |
| Bus. US 8 | 7.1 [2] | 11.4 | US 8 & WIS 47 west of Rhinelander | US 8/WIS 47 east of Rhinelander | 1992 [3] | 2005 [4] | Section of route east of town resigned as CTH-P | |
| Bus. US 10 | — | — | — | — | — | — | Serves Neillsville | |
| Bus. US 12 | — | — | — | — | — | — | Serves Lake Delton and Baraboo | |
| Bus. US 12 | — | — | — | — | — | — | Serves Sauk Prairie | |
| Bus. US 12 | — | — | — | — | — | — | Serves Whitewater | |
| Bus. US 12 | — | — | — | — | — | — | Formerly served Eau Claire | |
| Bus. US 14 | — | — | — | — | — | — | Serves Janesville | |
| Bus. US 16 | — | — | — | — | 1961 | 1979 | Formerly served Watertown | |
| Bus. US 18 | — | — | — | — | — | — | Serves Mount Horeb | |
 Alt. US 18 | — | — | — | — | — | — | Formerly served Milwaukee | |
| Bus. US 18 | — | — | — | — | — | — | Serves Verona | |
| Bus. US 41 | — | — | — | — | — | — | Formerly served Fond du Lac | |
| Bus. US 41 | — | — | — | — | — | — | Formerly served Oshkosh | |
| Bus. US 41 | — | — | — | — | — | — | Formerly served Appleton | |
| Bus. US 41 | — | — | — | — | — | — | Serves De Pere and Ashwaubenon; state-maintained | |
| Bus. US 41 | — | — | — | — | — | — | Formerly served Green Bay | |
| Bus. US 41 | — | — | — | — | — | — | Serves Oconto | |
| Bus. US 41 | — | — | — | — | — | — | Serves Peshtigo | |
| Bus. US 45 | — | — | — | — | — | — | Serves New London | |
| Bus. US 45 | — | — | — | — | — | — | Serves Wittenberg | |
| Bus. US 51 | — | — | — | — | — | — | Formerly state-maintained and served Merrill | |
| Bus. US 51 | — | — | — | — | — | — | Serves Stevens Point and Plover; state-maintained | |
| Bus. US 51 | — | — | — | — | — | — | Serves Wausau, Schofield and Rothschild; state-maintained | |
 Spur US 51 | — | — | — | — | — | — | Unsigned in Beloit; state-maintained | |
| Bus. US 51 | — | — | — | — | — | — | Formerly served Tomahawk | |
| Bus. US 53 | — | — | — | — | — | — | Serves Eau Claire | |
| Bus. US 53 | — | — | — | — | — | — | Serves La Crosse | |
| Bus. US 53 | — | — | — | — | — | — | Serves Solon Springs | |
| Bus. US 53 | — | — | — | — | — | — | Serves Minong | |
| Bus. US 53 | — | — | — | — | — | — | Serves Superior | |
 Byp. US 53 | — | — | — | — | 2005 | 2006 | Temporary designation used at Eau Claire | |
| Bus. US 141 | — | — | — | — | — | — | Formerly served Manitowoc | |
| Bus. US 141 | 4.5 [5] | 7.2 | US 141 southwest of Coleman | US 141 and WIS 64 northeast of Pound | 2006 [6] [7] | current | Follows old alignment through Coleman and Pound | |
| Bus. US 141 | — | — | — | — | — | — | Formerly served Sheboygan | |
| Bus. US 151 | — | — | — | — | — | — | Serves Platteville | |
| Bus. US 151 | — | — | — | — | — | — | Serves Mineral Point | |
| Bus. US 151 | — | — | — | — | — | — | Serves Mount Horeb; cosigned with Bus. US 18 | |
| Bus. US 151 | — | — | — | — | — | — | Serves Verona; cosigned with Bus. US 18 | |
| Bus. US 151 | — | — | — | — | — | — | Serves Sun Prairie | |
| Bus. US 151 | — | — | — | — | — | — | Serves Columbus | |
| Bus. US 151 | — | — | — | — | — | — | Serves Beaver Dam | |
| Bus. US 151 | — | — | — | — | — | — | Serves Waupun | |
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