| No. | City | Province | 2022 Census | 2010 Census | 2001 Census | 1990 Census |
|---|---|---|---|---|---|---|
| 1 | Guayaquil | Guayas | 2,650,288 | 2,278,691 | 1,985,379 | 1,508,444 |
| 2 | Quito | Pichincha | 1,763,275 | 1,607,734 | 1,399,378 | 1,100,847 |
| 3 | Cuenca | Azuay | 361,524 | 329,928 | 277,374 | 194,981 |
| 4 | Santo Domingo | Santo Domingo | 334,826 | 270,875 | 199,827 | 114,422 |
| 5 | Durán | Guayas | 295,211 | 230,839 | 174,531 | 82,359 |
| 6 | Machala | El Oro | 288,072 | 231,260 | 204,578 | 144,197 |
| 7 | Manta | Manabí | 258,697 | 217,553 | 183,105 | 125,505 |
| 8 | Calderón | Pichincha | 249,941 | 149,235 | ||
| 9 | Portoviejo | Manabí | 244,129 | 206,682 | 171,847 | 132,937 |
| 10 | Loja | Loja | 203,496 | 170,280 | 118,532 | 94,305 |
| 11 | Quevedo | Los Ríos | 177,792 | 150,827 | 120,379 | 86,910 |
| 12 | Ambato | Tungurahua | 177,316 | 165,185 | 154,095 | 124,166 |
| 13 | Riobamba | Chimborazo | 177,213 | 146,324 | 124,807 | 94,505 |
| 14 | Milagro | Guayas | 159,970 | 133,508 | 113,440 | 93,637 |
| 15 | Ibarra | Imbabura | 157,941 | 131,856 | 108,535 | 80,991 |
| 16 | Esmeraldas | Esmeraldas | 155,487 | 154,035 | 95,124 | 98,558 |
| 17 | Conocoto | Pichincha | 121,984 | 69,973 | ||
| 18 | La Aurora | Guayas | 116,593 | 24,835 | ||
| 19 | La Libertad | Santa Elena | 112,154 | 95,942 | 77,646 | 53,108 |
| 20 | Babahoyo | Los Ríos | 98,251 | 90,191 | 76,869 | 50,285 |
| 21 | Sangolquí | Pichincha | 96,647 | 75,080 | 56,794 | 35,386 |
| 22 | Latacunga | Cotopaxi | 77,267 | 63,842 | 51,689 | 39,882 |
| 23 | Montecristi | Manabí | 71,066 | 46,312 | 14,636 | 9,642 |
| 24 | Tumbaco | Pichincha | 70,789 | |||
| 25 | Pasaje | El Oro | 60,147 | 52,673 | 45,526 | 32,947 |
| 26 | Santa Rosa | El Oro | 56,842 | 48,929 | 42,593 | 32,648 |
| 27 | Tulcán | Carchi | 56,719 | 53,558 | 47,359 | 37,069 |
| 28 | Huaquillas | El Oro | 56,021 | 47,706 | 40,183 | 27,368 |
| 29 | Nueva Loja | Sucumbíos | 55,627 | 48,562 | 34,106 | 13,165 |
| 30 | La Puntilla | Guayas | 55,357 | 29,803 | 13,073 | 4,578 |
| 31 | Chone | Manabí | 54,629 | 52,810 | 45,526 | 41,437 |
| 32 | Santa Elena | Santa Elena | 54,565 | 39,681 | 27,351 | 17,459 |
| 33 | El Carmen | Manabí | 52,366 | 46,358 | 33,382 | 22,870 |
| 34 | Puerto Francisco de Orellana | Orellana | 51,281 | 40,730 | 18,298 | 7,805 |
| 35 | Playas | Guayas | 48,156 | 34,409 | 24,070 | 16,590 |
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