U.S. Route 522 is a spur route of US 22 in the states of Virginia, West Virginia, Maryland, and Pennsylvania. The U.S. Highway travels in a north-south direction, and runs 308.59 miles (496.63 km) from US 60 near Powhatan, Virginia, to its northern terminus at US 11 and US 15 near Selinsgrove, Pennsylvania. US 522 serves many small cities and towns in the Piedmont, Blue Ridge Mountains, and northern Shenandoah Valley of Virginia. The highway serves the Virginia communities of Goochland, Mineral, Culpeper, the town of Washington, and Front Royal and the independent city of Winchester. US 522 then follows the Ridge-and-Valley Appalachians north and then east through the Eastern Panhandle of West Virginia, a 2-mile-wide (3.2 km) stretch of Western Maryland, and South Central Pennsylvania to its terminus in the Susquehanna Valley. The highway serves Berkeley Springs, West Virginia; Hancock, Maryland; and the Pennsylvania communities of McConnellsburg, Mount Union, Lewistown, and Middleburg.
Maryland Route 2 is the longest state highway in the U.S. state of Maryland. The 79.24-mile (127.52 km) route runs from Solomons Island in Calvert County north to an intersection with U.S. Route 1 /US 40 Truck in Baltimore. The route runs concurrent with MD 4 through much of Calvert County along a four-lane divided highway known as Solomons Island Road, passing through rural areas as well as the communities of Lusby, Port Republic, Prince Frederick, and Huntingtown. In Sunderland, MD 2 splits from MD 4 and continues north as two-lane undivided Solomons Island Road into Anne Arundel County, still passing through rural areas. Upon reaching Annapolis, the route runs concurrent with US 50/US 301 to the north of the city. Between Annapolis and Baltimore, MD 2 runs along the Governor Ritchie Highway, a multilane divided highway that heads through suburban areas, passing through Arnold, Severna Park, Pasadena, Glen Burnie, and Brooklyn Park. In Baltimore, the route heads north on city streets and passes through the downtown area of the city.
Maryland Route 7 (MD 7) is a collection of state highways in the U.S. state of Maryland. Known for much of their length as Philadelphia Road, there are five disjoint mainline sections of the highway totaling 40.23 miles (64.74 km) that parallel U.S. Route 40 (US 40) in Baltimore, Harford, and Cecil counties in northeastern Maryland. The longest section of MD 7 begins at US 40 just east of the city of Baltimore in Rosedale and extends through eastern Baltimore County and southern Harford County to US 40 in Aberdeen. The next segment of the state highway is a C-shaped route through Havre de Grace on the west bank of the Susquehanna River. The third mainline section of MD 7 begins in Perryville on the east bank of the Susquehanna River and ends at US 40 a short distance west of the start of the fourth section, which passes through Charlestown and North East before ending at US 40, just west of Elkton. The fifth segment of the highway begins at South Street and passes through the eastern part of Elkton before reconnecting with US 40 east of Elkton and west of the Delaware state line.
Maryland Route 355 (MD 355) is a 36.75-mile (59.14 km) north–south road in western central Maryland in the United States. The southern terminus of the route, Wisconsin Avenue, is located in Bethesda in Montgomery County, at the county's border with Washington, D.C. It continues south into Washington, D.C. as Wisconsin Avenue NW. The northern terminus is just north of a bridge over Interstate 70 (I-70)/U.S. Route 40 (US 40) in the city of Frederick in Frederick County, where the road continues north as Market Street through Frederick towards MD 26.
Maryland Route 99 is a state highway in the U.S. state of Maryland. Known as Old Frederick Road, the state highway runs 7.57 miles (12.18 km) from MD 32 near West Friendship east to U.S. Route 29 in Ellicott City. MD 99 parallels the north side of Interstate 70 (I-70) through a rural and suburban area in northeastern Howard County. MD 99, which follows the original 18th-century road west from Baltimore, was constructed as part of three state highways: MD 99, the original MD 100, and MD 105. All three highways were constructed between the early 1920s and early 1930s. MD 99 originally turned south along St. Johns Lane to US 40 and MD 144; in 1956, the state highway was rerouted along part of MD 100 and all of MD 105 to downtown Ellicott City. MD 99's eastern terminus was rolled back to US 29 in two steps in the late 1970s and late 1980s.
Maryland Route 140 is a 49-mile (79 km) state highway in the U.S. state of Maryland. The route runs from U.S. Route 1 and US 40 Truck in Baltimore northwest to the Pennsylvania border, where the road continues into that state as Pennsylvania Route 16. MD 140 passes through the northern part of central Maryland, connecting Baltimore, Pikesville, Reisterstown, Westminster, Taneytown, and Emmitsburg.
Maryland Route 85 is a state highway in the U.S. state of Maryland. Known as Buckeystown Pike, the state highway runs 10.80 miles (17.38 km) from MD 28 in Tuscarora north to the Frederick city limit north of Interstate 70 (I-70), where the highway continues north as East Street. MD 85 connects Tuscarora and Buckeystown in southern Frederick County with the county seat of Frederick. The state highway also links the suburban area between Buckeystown and Frederick with I-70 and I-270. MD 85 is the old alignment of U.S. Route 15, which was originally constructed between Tuscarora and Frederick in the late 1910s and early 1920s. MD 85 was assigned to the highway in 1970 when US 15 was moved to a new highway heading north from its Potomac River crossing at Point of Rocks. The state highway was extended north to the city of Frederick as part of a project to overhaul MD 355's interchange with I-70 in the first decade of the 21st century.
Maryland Route 180 is a state highway in the U.S. state of Maryland. Known for most of its length as Jefferson Pike, the state highway runs 14.95 miles (24.06 km) from U.S. Route 340 in Knoxville east to Ballenger Creek Pike and Interstate 70 (I-70) in Frederick. MD 180 is the old alignment of US 340 through Knoxville, Petersville, and Jefferson in the Middletown Valley of western Frederick County. The state highway was originally constructed in the early 1910s and designated US 340 in 1927. MD 180 was assigned to the highway bypassed by the US 340 freeway between Sandy Hook in far southern Washington County and Jefferson in the mid-1960s. The state highway was extended east to Frederick and south along Ballenger Creek Pike after the US 340 freeway was completed in the late 1960s. MD 180 was rolled back to Frederick and removed from Washington County in 1989.
Interstate 70 (I-70) is a part of the Interstate Highway System that runs from Cove Fort, Utah, to Baltimore, Maryland. In Maryland, the Interstate Highway runs 93.62 miles (150.67 km) from the Pennsylvania state line in Hancock east to the Interstate's eastern terminus near its junction with I-695 at a park and ride in Baltimore. I-70 is the primary east–west Interstate in Maryland; the Interstate Highway connects Baltimore—and Washington, D.C., via I-270—with Western Maryland. The Interstate serves Frederick and Hagerstown directly and provides access to Cumberland via its junction with I-68 at Hancock. I-70 runs concurrently with its predecessor highway, U.S. Route 40 (US 40), from Hancock to Indian Springs in Washington County and from Frederick to West Friendship in Howard County.
U.S. Route 40 in the U.S. state of Maryland runs from Garrett County in Western Maryland to Cecil County in the state's northeastern corner. With a total length of 221 miles (356 km), it is the longest numbered highway in Maryland. Almost half of the road overlaps or parallels with Interstate 68 (I-68) or I-70, while the old alignment is generally known as US 40 Alternate, US 40 Scenic, or Maryland Route 144. West of Baltimore, in the Piedmont and Appalachian Mountains / Blue Ridge region of the Western Maryland panhandle of the small state, the portions where it does not overlap an Interstate highway are mostly two-lane roads. The portion northeast of Baltimore going toward Wilmington in northern Delaware and Philadelphia in southeastern Pennsylvania is a four-lane divided highway, known as the Pulaski Highway. This section crosses the Susquehanna River at the north end of the Chesapeake Bay on the Thomas J. Hatem Memorial Bridge.
Maryland Route 56 is a state highway in the U.S. state of Maryland. Known as Big Pool Road, the state highway runs 8.08 miles (13.00 km) from Interstate 70 (I-70) in Big Pool east to MD 68 near Pinesburg in western Washington County. MD 56, which features a pair of one-lane bridges, provides access to Fort Frederick State Park and the eastern trailhead of the Western Maryland Rail Trail. The state highway was first constructed in the mid 1910s from what is now U.S. Route 40 south to Big Pool. The highway was extended east toward the village of Big Spring in the early 1930s and to MD 68 in the late 1950s. MD 56 was truncated at I-70 in the mid-1990s.
Maryland Route 166 is a state highway in the U.S. state of Maryland. The state highway runs 2.71 miles (4.36 km) from Interstate 195 (I-195) in Arbutus north to MD 144 in Catonsville. MD 166 consists of two sections: a short freeway section that serves as a northern continuation of I-195 and provides access to the University of Maryland, Baltimore County (UMBC), and a segment of Rolling Road, a major north–south highway in western Baltimore County. Rolling Road dates to the colonial era as a highway used to transport tobacco from plantations to river ports. North Rolling Road, which connects Catonsville with Woodlawn and Milford Mill, has always been a county highway. South Rolling Road was constructed as a state highway by the early 1920s between what were to become U.S. Route 1 and US 40. Parts of South Rolling Road were transferred to county maintenance after they were severed by the construction of I-95 and a freeway relocation of the southern end of MD 166 in the early 1970s.
Maryland Route 75 is a state highway in the U.S. state of Maryland. Known for most of its length as Green Valley Road, the state highway runs 28.40 miles (45.71 km) from MD 355 near Hyattstown north to MD 31 in New Windsor. MD 75 serves as the main north–south highway of eastern Frederick County, where it connects Hyattstown with New Market, Libertytown, Johnsville, and the Carroll County town of Union Bridge. The first sections of MD 75 were constructed around New Windsor and between Green Valley and New London in the early 1910s. The latter highway was extended south to Green Valley in the late 1910s. In the early 1920s, MD 75 was constructed between New Windsor and Union Bridge and from Libertytown to Johnsville. The remainder of the state highway was constructed in the late 1920s and early 1930s. MD 75 was relocated between Union Bridge and New Windsor in the early 1960s, around its interchange with Interstate 70 (I-70)/U.S. Route 40 in New Market in the early 1970s, and at its northern terminus in New Windsor in 2007.
Maryland Route 615 (MD 615) is a state highway in the U.S. state of Maryland. The state highway runs 4.35 miles (7.00 km) from Interstate 70 (I-70) and U.S. Route 40 (US 40) east of Hancock north to the Pennsylvania state line, where the highway continues as State Route 2001 (SR 2001) in Fulton County. MD 615 has two sections, an east–west section that closely parallels I-70 and US 40 and a north–south highway that follows Heavenly Acres Ridge. The ridge road was constructed as MD 615 in the mid-1930s. The east–west segment is part of the original alignment of US 40 constructed in the mid-1910s. After I-70 was constructed east of Hancock in the early 1960s, MD 615 was extended to its current length parallel to the new freeway.
U.S. Route 220 is a part of the U.S. Highway System that runs from Rockingham, North Carolina, to South Waverly, Pennsylvania. In Maryland, the federal highway runs 27.30 miles (43.94 km) from the West Virginia state line at the North Branch Potomac River in McCoole north to the Pennsylvania state line in Dickens. Known as McMullen Highway for much of its length in Maryland, US 220 is the primary north–south route in central Allegany County, connecting Cumberland with its southern suburbs and Keyser, West Virginia, to the south and Bedford, Pennsylvania, to the north. The federal highway is part of the National Highway System between the West Virginia state line and Maryland Route 53 in Cresaptown and between Interstate 68 (I-68), with which it is concurrent through Cumberland, and the Pennsylvania state line.
Maryland Route 132 is a collection of state highways in the U.S. state of Maryland. These four highways are sections of old alignment of and connecting roads with MD 22 in Aberdeen, Harford County. MD 132 connects Aberdeen neighborhoods east and west of U.S. Route 40 with MD 22 and Interstate 95 (I-95). MD 132B serves the area east of US 40 and north of MD 22 between Aberdeen and Havre de Grace. MD 132A and MD 132C are connectors between MD 132 and MD 22. The highways that are now part of MD 132 were originally built in the early 1910s and marked as part of MD 22 and US 40 in 1927. MD 22 was extended east and north along the US 40 portion when the U.S. highway was relocated in the 1930s. MD 132 was assigned to the highway when MD 22 was relocated in the late 1960s. MD 132 became a split route following the construction of a railroad grade separation in the 1980s.
Maryland Route 155 is a state highway in the U.S. state of Maryland. Known for most of its length as Level Road, the state highway runs 9.06 miles (14.58 km) from MD 22 in Churchville east to U.S. Route 40 and MD 7 in Havre de Grace. In conjunction with MD 22, MD 155 serves as the main highway linking Bel Air and Havre de Grace in eastern Harford County. The state highway also connects Havre de Grace with Interstate 95 (I-95) and Susquehanna State Park. The first portion of MD 155 near Havre de Grace was built by 1910; the remainder of the highway east of Hopewell Village was completed in the mid-1920s. The Churchville–Hopewell Village portion of the state highway, originally designated MD 156, was built in the mid-1930s. MD 155 received its present designation over its western half in 1952 when MD 155 and MD 156 swapped paths.
U.S. Route 40 Scenic (US 40 Scenic) is a scenic route of US 40 in the U.S. state of Maryland. US 40 Scenic, which is known for most of its route as National Pike, is the old alignment of US 40 over Town Hill in eastern Allegany County and Sideling Hill in far western Washington County. The highway was originally constructed as part of a turnpike connecting Baltimore with the eastern end of the National Road at Cumberland in the early 19th century. The highway was paved as a modern road in the mid-1910s and designated US 40 in the late 1920s. US 40 was relocated over Sideling Hill in the early 1950s and over Town Hill in the mid-1960s. The US 40 Scenic designation was first applied to the old highway over Town Hill in 1965. Following the completion of Interstate 68 (I-68) at Sideling Hill, US 40 Scenic was extended east along old US 40's crossing of the mountain in the late 1980s. US 40 Scenic is the only scenic route in the U.S. Highway System; formerly, there was a second, US 412 Scenic in Oklahoma, but this has since been redesignated to a more conventional "Alternate" route.
U.S. Route 40 Alternate (US 40 Alternate) is an alternate route of US 40 in the U.S. state of Maryland. The highway runs 22.97 miles (36.97 km) from Potomac Street in Hagerstown east to US 40 in Frederick. US 40 Alternate parallels US 40 and much of Interstate 70 (I-70) to the south through eastern Washington County and western Frederick County. The alternate route connects Hagerstown and Frederick with Funkstown, Boonsboro, Middletown, and Braddock Heights. US 40 Alternate crosses two major north–south components of the Blue Ridge Mountains that separate the Great Appalachian Valley and the Piedmont: South Mountain between Boonsboro and Middletown and Catoctin Mountain, which is locally known as Braddock Mountain, at Braddock Heights.
Historic National Road 
Chesapeake and Ohio Canal Scenic Byway 
