Morinamide

Last updated

Morinamide
Morinamide.svg
Clinical data
Trade names Piazolina
AHFS/Drugs.com International Drug Names
ATC code
Legal status
Legal status
Identifiers
  • N-(morpholin-4-ylmethyl)pyrazine-2-carboxamide
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
CompTox Dashboard (EPA)
ECHA InfoCard 100.012.237 OOjs UI icon edit-ltr-progressive.svg
Chemical and physical data
Formula C10H14N4O2
Molar mass 222.248 g·mol−1
3D model (JSmol)
  • O=C(NCN1CCOCC1)c1cnccn1
  • InChI=1S/C10H14N4O2/c15-10(9-7-11-1-2-12-9)13-8-14-3-5-16-6-4-14/h1-2,7H,3-6,8H2,(H,13,15)
  • Key:GVTLAVKAVSKBKK-UHFFFAOYSA-N
   (verify)

Morinamide (or morphazinamide, or morinamid) is a drug used in the treatment of tuberculosis. [2] Although morphazinamide is metabolized to pyrazinamide within the body, [3] the drug itself has intrinsic in vitro activity. [4]

References

  1. Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
  2. Bonanni G, Ciccariello M, Mancini P, Pace V, Sagliaschi G (1993). "Concomitant ceco-appendicular and urinary tuberculosis. Description of two rare cases: physiopathological and diagnostic remarks". Riv Eur Sci Med Farmacol. 15 (3–4): 171–174. PMID   7761665.
  3. Trnka L, Kuška J, Havel A (1964). "Comparison of the Antituberculous Activity of Morphazinamide and Pyrazinamide on Chronic Experimental Tuberculosis. I. The Antimycobacterial Efficacy made in vitro and in vivo". Chemotherapia. 9 (3): 158–167. doi:10.1159/000220356.
  4. Carrada Bravo T, Ellard G, Mitchison D, Horsfall P (1975). "Reappraisal of the activity of morphazinamide against M. tuberculosis". Tubercle. 56 (3): 211–217. doi:10.1016/0041-3879(75)90054-9.