Terizidone

Terizidone
Clinical data
Trade names	Terivalidin
Other names	4-[({4-[N-(3-oxo-1,2-oxazolidin-4-yl)carboximidoyl]phenyl}methylidene)amino]-1,2-oxazolidin-3-one
AHFS/Drugs.com	International Drug Names
ATC code	J04AK03 ( WHO );
Identifiers
	IUPAC name 4,4'-{{#parsoidfragment:3}}{1,4-phenylenebis[(E)methylylidene; (E)azanylylidene]}bis(1,2-oxazolidin-3-one);
CAS Number	25683-71-0 ;
PubChem CID	65720 ;
ChemSpider	59144 ;
UNII	1199LEX5N8 ;
KEGG	D07247 ;
CompTox Dashboard (EPA)	DTXSID70905098 ;
ECHA InfoCard	100.042.882
Chemical and physical data
Formula	C14H14N4O4
Molar mass	302.290 g·mol−1
3D model (JSmol)	Interactive image ;
	SMILES O=C3NOCC3/N=C/c2ccc(/C=N/C1C(=O)NOC1)cc2;
	InChI InChI=1S/C14H14N4O4/c19-13-11(7-21-17-13)15-5-9-1-2-10(4-3-9)6-16-12-8-22-18-14(12)20/h1-6,11-12H,7-8H2,(H,17,19)(H,18,20)/b15-5+,16-6+ ; Key:ODKYYBOHSVLGNU-IAGONARPSA-N ;
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Last updated October 05, 2025

Terizidone is a drug used in the treatment of tuberculosis.^[1] Terizidone is mainly used in multi-drug-resistant tuberculosis (MDR-TB) in conjunction with other second-line drugs. It is a derivative of cycloserine with bacteriostatic activity.^[2]

Terizidone is a therapeutic alternative on the World Health Organization's List of Essential Medicines.^[3]

References

↑ Galietti F, Giorgis GE, Oliaro A, Boaro D, Ardizzi A, Barberis S, et al. (1991). "[Tolerability to terizidone (TZ) in the treatment of pulmonary tuberculosis in dialyzed patients]". Minerva Medica. 82 (7–8): 477–81. PMID 1922892.
↑ Rossiter D (2012). South African Medicines Formulary. Cape Town, South Africa: Health and Medical Publishing Group of the South African Medical Association. pp. 323–325. ISBN 978-1-875098-28-6.
↑ World Health Organization (2025). The selection and use of essential medicines, 2025: WHO Model List of Essential Medicines, 24th list. Geneva: World Health Organization. doi:10.2471/B09474. hdl: 10665/382243 .

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[1] Galietti F, Giorgis GE, Oliaro A, Boaro D, Ardizzi A, Barberis S, et al. (1991). "[Tolerability to terizidone (TZ) in the treatment of pulmonary tuberculosis in dialyzed patients]". Minerva Medica. 82 (7–8): 477–81. PMID 1922892.

[2] Rossiter D (2012). South African Medicines Formulary. Cape Town, South Africa: Health and Medical Publishing Group of the South African Medical Association. pp. 323–325. ISBN 978-1-875098-28-6.

[WHO24th-3] World Health Organization (2025). The selection and use of essential medicines, 2025: WHO Model List of Essential Medicines, 24th list. Geneva: World Health Organization. doi:10.2471/B09474. hdl: 10665/382243 .

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