Durlobactam

Durlobactam
Clinical data
Other names	ETX2514
Routes of; administration	Intravenous
Drug class	Antibacterial, beta-lactamase inhibitor
ATC code	None;
Legal status
Legal status	US: ℞-only co-packaged with sulbactam;
Identifiers
	IUPAC name [(2S,5R)-2-carbamoyl-3-methyl-7-oxo-1,6-diazabicyclo[3.2.1]oct-3-en-6-yl] hydrogen sulfate;
CAS Number	1467829-71-5 ;
PubChem CID	89851852 ;
DrugBank	DB16704 ; DBSALT003190 ;
ChemSpider	57617784 ; 71060725 ;
UNII	PSA33KO9WA ; F78MDZ9CW9 ;
KEGG	D11591 ; D11592 ;
ChEMBL	ChEMBL4298137 ; ChEMBL4297378 ;
Chemical and physical data
Formula	C8H11N3O6S
Molar mass	277.25 g·mol−1
3D model (JSmol)	Interactive image ;
	SMILES CC1=C[C@@H]2C[N@]([C@@H]1C(N)=O)C(=O)N2OS(O)(=O)=O;
	InChI InChI=1S/C8H11N3O6S/c1-4-2-5-3-10(6(4)7(9)12)8(13)11(5)17-18(14,15)16/h2,5-6H,3H2,1H3,(H2,9,12)(H,14,15,16)/t5-,6+/m1/s1; Key:BISPBXFUKNXOQY-RITPCOANSA-N;

Last updated September 30, 2025

Durlobactam is a beta-lactamase inhibitor used in combination with sulbactam to treat susceptible strains of bacteria in the genus Acinetobacter ^[1] It is an analog of avibactam.

References

1 2 "FDA Approves New Treatment for Pneumonia Caused by Certain Difficult-to-Treat Bacteria". U.S. Food and Drug Administration (Press release). 24 May 2023. Retrieved 24 May 2023.^{[ dead link ]} This article incorporates text from this source, which is in the public domain .

Shapiro AB, Moussa SH, McLeod SM, Durand-Réville T, Miller AA (2021). "Durlobactam, a New Diazabicyclooctane β-Lactamase Inhibitor for the Treatment of Acinetobacter Infections in Combination With Sulbactam". Frontiers in Microbiology. 12 709974. doi: 10.3389/fmicb.2021.709974 . PMC 8328114 . PMID 34349751.
Papp-Wallace KM, McLeod SM, Miller AA (May 2023). "Durlobactam, a Broad-Spectrum Serine β-lactamase Inhibitor, Restores Sulbactam Activity Against Acinetobacter Species". Clinical Infectious Diseases. 76 (Supplement_2): S194 –S201. doi:10.1093/cid/ciad095. PMC 10150275 . PMID 37125470.

This systemic antibiotic-related article is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[FDA_PR_20230523-1] 1 2 "FDA Approves New Treatment for Pneumonia Caused by Certain Difficult-to-Treat Bacteria". U.S. Food and Drug Administration (Press release). 24 May 2023. Retrieved 24 May 2023.^{[ dead link ]} This article incorporates text from this source, which is in the public domain .

[1]

Durlobactam

Contents

See also

References

Further reading

Clinical data

Other names	ETX2514
Routes of administration	Intravenous
Drug class	Antibacterial, beta-lactamase inhibitor
ATC code	None
Legal status
Legal status	US: ℞-only co-packaged with sulbactam
Identifiers
IUPAC name [(2S,5R)-2-carbamoyl-3-methyl-7-oxo-1,6-diazabicyclo[3.2.1]oct-3-en-6-yl] hydrogen sulfate
CAS Number	1467829-71-5
PubChem CID	89851852
DrugBank	DB16704 DBSALT003190
ChemSpider	57617784 71060725
UNII	PSA33KO9WA F78MDZ9CW9
KEGG	D11591 D11592
ChEMBL	ChEMBL4298137 ChEMBL4297378
Chemical and physical data
Formula	C₈H₁₁N₃O₆S
Molar mass	277.25 g·mol⁻¹
3D model (JSmol)	Interactive image
SMILES CC1=C[C@@H]2C[N@]([C@@H]1C(N)=O)C(=O)N2OS(O)(=O)=O
InChI InChI=1S/C8H11N3O6S/c1-4-2-5-3-10(6(4)7(9)12)8(13)11(5)17-18(14,15)16/h2,5-6H,3H2,1H3,(H2,9,12)(H,14,15,16)/t5-,6+/m1/s1 Key:BISPBXFUKNXOQY-RITPCOANSA-N