Prothionamide

Prothionamide
Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	J04AD01 ( WHO );
Identifiers
	IUPAC name 2-propylpyridine-4-carbothioamide;
CAS Number	14222-60-7 ;
PubChem CID	666418 ;
DrugBank	DB12667 ;
ChemSpider	579891 ;
UNII	76YOO33643 ;
CompTox Dashboard (EPA)	DTXSID7045940 ;
ECHA InfoCard	100.034.615
Chemical and physical data
Formula	C9H12N2S
Molar mass	180.27 g·mol−1
3D model (JSmol)	Interactive image ;
	SMILES CCCc1cc(ccn1)C(=S)N;
	InChI InChI=1S/C9H12N2S/c1-2-3-8-6-7(9(10)12)4-5-11-8/h4-6H,2-3H2,1H3,(H2,10,12) ; Key:VRDIULHPQTYCLN-UHFFFAOYSA-N ;
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Last updated June 15, 2025

Protionamide (or prothionamide) is a drug used in the treatment of tuberculosis and leprosy.^[1]^[2]

References

↑ Wang F, Langley R, Gulten G, et al. (January 2007). "Mechanism of thioamide drug action against tuberculosis and leprosy". J. Exp. Med. 204 (1): 73–8. doi:10.1084/jem.20062100. PMC 2118422 . PMID 17227913.
↑ Fajardo TT, Guinto RS, Cellona RV, Abalos RM, Dela Cruz EC, Gelber RH (March 2006). "A clinical trial of ethionamide and prothionamide for treatment of lepromatous leprosy" . Am. J. Trop. Med. Hyg. 74 (3): 457–61. doi: 10.4269/ajtmh.2006.74.457 . PMID 16525107. S2CID 21415032.

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[pmid17227913-1] Wang F, Langley R, Gulten G, et al. (January 2007). "Mechanism of thioamide drug action against tuberculosis and leprosy". J. Exp. Med. 204 (1): 73–8. doi:10.1084/jem.20062100. PMC 2118422 . PMID 17227913.

[pmid16525107-2] Fajardo TT, Guinto RS, Cellona RV, Abalos RM, Dela Cruz EC, Gelber RH (March 2006). "A clinical trial of ethionamide and prothionamide for treatment of lepromatous leprosy" . Am. J. Trop. Med. Hyg. 74 (3): 457–61. doi: 10.4269/ajtmh.2006.74.457 . PMID 16525107. S2CID 21415032.

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