NADP-retinol dehydrogenase

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NADP-retinol dehydrogenase
Identifiers
EC no. 1.1.1.300
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
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PMC articles
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NCBI proteins

NADP-retinol dehydrogenase (EC 1.1.1.300, all-trans retinal reductase, all-trans-retinol dehydrogenase, NADP(H)-dependent retinol dehydrogenase/reductase, RDH11 , RDH12 , RDH13 , RDH14 , retinol dehydrogenase 12, retinol dehydrogenase 14, retinol dehydrogenase (NADP+), RalR1, PSDR1) is an enzyme with systematic name retinol:NADP+ oxidoreductase. [1] [2] [3] [4] This enzyme catalyses the following chemical reaction: [5]

 
 
 
H+
NADP-retinol dehydrogenase
 
H+
 
 

This enzyme has greater catalytic efficiency in the reductive direction.

References

  1. Belyaeva OV, Korkina OV, Stetsenko AV, Kim T, Nelson PS, Kedishvili NY (May 2005). "Biochemical properties of purified human retinol dehydrogenase 12 (RDH12): catalytic efficiency toward retinoids and C9 aldehydes and effects of cellular retinol-binding protein type I (CRBPI) and cellular retinaldehyde-binding protein (CRALBP) on the oxidation and reduction of retinoids". Biochemistry. 44 (18): 7035–47. doi:10.1021/bi050226k. PMC   2679700 . PMID   15865448.
  2. Belyaeva OV, Korkina OV, Stetsenko AV, Kedishvili NY (January 2008). "Human retinol dehydrogenase 13 (RDH13) is a mitochondrial short-chain dehydrogenase/reductase with a retinaldehyde reductase activity". The FEBS Journal. 275 (1): 138–47. doi:10.1111/j.1742-4658.2007.06184.x. PMC   2573044 . PMID   18039331.
  3. Haeseleer F, Huang J, Lebioda L, Saari JC, Palczewski K (August 1998). "Molecular characterization of a novel short-chain dehydrogenase/reductase that reduces all-trans-retinal". The Journal of Biological Chemistry. 273 (34): 21790–9. doi: 10.1074/jbc.273.34.21790 . PMID   9705317.
  4. Kedishvili NY, Chumakova OV, Chetyrkin SV, Belyaeva OV, Lapshina EA, Lin DW, Matsumura M, Nelson PS (August 2002). "Evidence that the human gene for prostate short-chain dehydrogenase/reductase (PSDR1) encodes a novel retinal reductase (RalR1)". The Journal of Biological Chemistry. 277 (32): 28909–15. doi: 10.1074/jbc.M202588200 . PMID   12036956.
  5. Enzyme 1.1.1.300 at KEGG Pathway Database.