Orotate reductase (NADPH)

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orotate reductase (NADPH)
Identifiers
EC no. 1.3.1.15
CAS no. 37255-27-9
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In enzymology, an orotate reductase (NADPH) (EC 1.3.1.15) is an enzyme that catalyzes the chemical reaction

(S)-dihydroorotate + NADP+ orotate + NADPH + H+

Thus, the two substrates of this enzyme are (S)-dihydroorotate and NADP+, whereas its 3 products are orotate, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (S)-dihydroorotate:NADP+ oxidoreductase. Other names in common use include orotate reductase, dihydroorotate dehydrogenase, dihydro-orotic dehydrogenase, L-5,6-dihydro-orotate:NAD+ oxidoreductase, and orotate reductase (NADPH). It has one cofactor, FAD.

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References


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