Ototoxicity

Last updated
Ototoxicity
Specialty Otorhinolaryngology

Ototoxicity is the property of being toxic to the ear (oto-), specifically the cochlea or auditory nerve and sometimes the vestibular system, for example, as a side effect of a drug. The effects of ototoxicity can be reversible and temporary, or irreversible and permanent. It has been recognized since the 19th century. [1] There are many well-known ototoxic drugs used in clinical situations, and they are prescribed, despite the risk of hearing disorders, for very serious health conditions. [2] Ototoxic drugs include antibiotics (such as gentamicin, streptomycin, tobramycin), loop diuretics (such as furosemide), and platinum-based chemotherapy agents (such as cisplatin and carboplatin). A number of nonsteroidal anti-inflammatory drugs (NSAIDS) have also been shown to be ototoxic. [3] [4] This can result in sensorineural hearing loss, dysequilibrium, or both. Some environmental and occupational chemicals have also been shown to affect the auditory system and interact with noise. [5]

Contents

Signs and symptoms

Symptoms of ototoxicity include partial or profound hearing loss, vertigo, and tinnitus. [6]

The cochlea is primarily a hearing structure situated in the inner ear. It is the snail-shaped shell containing several nerve endings that makes hearing possible. [7] Ototoxicity typically results when the inner ear is poisoned by medication that damages the cochlea, vestibule, semi-circular canals, or the auditory/ vestibulocochlear nerve. The damaged structure then produces the symptoms the patient presents with. Ototoxicity in the cochlea may cause hearing loss of the high-frequency pitch ranges or complete deafness, or losses at points between. [8] It may present with bilaterally symmetrical symptoms, or asymmetrically, with one ear developing the condition after the other or not at all. [8] The time frames for progress of the disease vary greatly and symptoms of hearing loss may be temporary or permanent. [7]

The vestibule and semi-circular canal are inner-ear components that comprise the vestibular system. Together they detect all directions of head movement. Two types of otolith organs are housed in the vestibule: the saccule, which points vertically and detects vertical acceleration, and the utricle, which points horizontally and detects horizontal acceleration. The otolith organs together sense the head's position with respect to gravity when the body is static; then the head's movement when it tilts; and pitch changes during any linear motion of the head. The saccule and utricle detect different motions, which information the brain receives and integrates to determine where the head is and how and where it is moving.

The semi-circular canals are three bony structures filled with fluid. As with the vestibule, the primary purpose of the canals is to detect movement. Each canal is oriented at right angles to the others, enabling detection of movement in any plane. The posterior canal detects rolling motion, or motion about the X axis; the anterior canal detects pitch, or motion about the Y axis; the horizontal canal detects yaw motion, or motion about the Z axis. When a medication is toxic in the vestibule or the semi-circular canals, the patient senses loss of balance or orientation rather than losses in hearing. Symptoms in these organs present as vertigo, difficulties walking in low light and darkness, disequilibrium, oscillopsia among others. [8] Each of these problems is related to balance and the mind is confused with the direction of motion or lack of motion. Both the vestibule and semi-circular canals transmit information to the brain about movement; when these are poisoned, they are unable to function properly which results in miscommunication with the brain.

When the vestibule and/or semi-circular canals are affected by ototoxicity, the eye can also be affected. Nystagmus and oscillopsia are two conditions that overlap the vestibular and ocular systems. These symptoms cause the patient to have difficulties with seeing and processing images. The body subconsciously tries to compensate for the imbalance signals being sent to the brain by trying to obtain visual cues to support the information it is receiving. This results in that dizziness and "woozy" feeling patients use to describe conditions such as oscillopsia and vertigo. [8]

Cranial nerve VIII is the least affected component of the ear when ototoxicity arises, but if the nerve is affected, the damage is most often permanent. Symptoms present similar to those resulting from vestibular and cochlear damage, including tinnitus, ringing of the ears, difficulty walking, deafness, and balance and orientation issues.

Ototoxic agents

Antibiotics

Antibiotics in the aminoglycoside class, such as gentamicin and tobramycin, may produce cochleotoxicity through a poorly understood mechanism. [9] It may result from antibiotic binding to NMDA receptors in the cochlea and damaging neurons through excitotoxicity. [10] Aminoglycoside-induced production of reactive oxygen species may also injure cells of the cochlea. [11] Once-daily dosing [12] and co-administration of N-acetylcysteine [13] may protect against aminoglycoside-induced ototoxicity. The anti-bacterial activity of aminoglycoside compounds is due to inhibition of ribosome function and these compounds similarly inhibit protein synthesis by mitochondrial ribosomes because mitochondria evolved from a bacterial ancestor. [14] Consequently, aminoglycoside effects on production of reactive oxygen species as well as dysregulation of cellular calcium ion homeostasis may result from disruption of mitochondrial function. [15] Ototoxicity of gentamicin can be exploited to treat some individuals with Ménière's disease by destroying the inner ear, which stops the vertigo attacks but causes permanent deafness. [16] Due to the effects on mitochondria, certain inherited mitochondrial disorders result in increased sensitivity to the toxic effects of aminoglycosides.

Macrolide antibiotics, including erythromycin, are associated with reversible ototoxic effects. [6] The underlying mechanism of ototoxicity may be impairment of ion transport in the stria vascularis. [6] Predisposing factors include renal impairment, hepatic impairment, and recent organ transplantation. [6]

Loop diuretics

Certain types of diuretics are associated with varying levels of risk for ototoxicity. Loop and thiazide diuretics carry this side effect. The loop diuretic furosemide is associated with ototoxicity, particularly when doses exceed 240 mg per hour. [17] The related compound ethacrynic acid has a higher association with ototoxicity, and is therefore used only in patients with sulfa allergies. Diuretics are thought to alter the ionic gradient within the stria vascularis. [18] Bumetanide confers a decreased risk of ototoxicity compared to furosemide. [6]

Chemotherapeutic agents

Platinum-containing chemotherapeutic agents, including cisplatin and carboplatin, are associated with cochleotoxicity characterized by progressive, high-frequency hearing loss with or without tinnitus (ringing in the ears). [19] Ototoxicity is less frequently seen with the related compound oxaliplatin. [20] The severity of cisplatin-induced ototoxicity is dependent upon the cumulative dose administered [21] and the age of the patient, with young children being most susceptible. [22] The exact mechanism of cisplatin ototoxicity is not known. The drug is understood to damage multiple regions of the cochlea, causing the death of outer hair cells, as well as damage to the spiral ganglion neurons and cells of the stria vascularis. [23] Long-term retention of cisplatin in the cochlea may contribute to the drug's cochleotoxic potential. [24] Once inside the cochlea, cisplatin has been proposed to cause cellular toxicity through a number of different mechanisms, including through the production of reactive oxygen species. [25] The decreased incidence of oxaliplatin ototoxicity has been attributed to decreased uptake of the drug by cells of the cochlea. [20] Administration of amifostine has been used in attempts to prevent cisplatin-induced ototoxicity, but the American Society of Clinical Oncology recommends against its routine use. [26]

The vinca alkaloids, [27] [28] [29] including vincristine, [30] are also associated with reversible ototoxicity. [6]

Antiseptics and disinfectants

Topical skin preparations such as chlorhexidine and ethyl alcohol have the potential to be ototoxic should they enter the inner ear through the round window membrane. [6] This potential was first noted after a small percentage of patients undergoing early myringoplasty operations experienced severe sensorineural hearing loss. It was found that in all operations involving this complication the preoperative sterilization was done with chlorhexidine. [31] The ototoxicity of chlorhexidine was further confirmed by studies with animal models. [6]

Several other skin preparations have been shown to be potentially ototoxic in the animal model. These preparations include acetic acid, propylene glycol, quaternary ammonium compounds, and any alcohol-based preparations. However, it is difficult to extrapolate these results to human ototoxicity because the human round window membrane is much thicker than in any animal model. [6]

Other medicinal ototoxic drugs

At high doses, quinine, aspirin and other salicylates may also cause high-pitch tinnitus and hearing loss in both ears, typically reversible upon discontinuation of the drug. [6] Erectile dysfunction medications may have the potential to cause hearing loss. [32] However the link between erectile dysfunction medications and hearing loss remains uncertain. [33]

Previous noise exposure has not been found to potentiate ototoxic hearing loss. [34] [35] The American Academy of Audiology includes in their position statement that exposure to noise at the same time as aminoglycosides may exacerbate ototoxicity. The American Academy of Audiology recommends people being treated with ototoxic chemotherapeutics avoid excessive noise levels during treatment and for several months following cessation of treatment. Opiates in combination with excessive noise levels may also have an additive effect on ototoxic hearing loss. [36]

Ototoxicants in the environment and workplace

Ototoxic effects are also seen with quinine, pesticides, solvents, asphyxiants, and heavy metals such as mercury and lead. [5] [6] [37] When combining multiple ototoxicants, the risk of hearing loss becomes greater. [38] [39] As these exposures are common, this hearing impairment can affect many occupations and industries. [40] [41] Examples of activities that often have exposures to both noise and solvents include: [42]

Ototoxic chemicals in the environment (from contaminated air or water) or in the workplace interact with mechanical stresses on the hair cells of the cochlea in different ways. For mixtures containing organic solvents such as toluene, styrene or xylene, the combined exposure with noise increases the risk of occupational hearing loss in a synergistic manner. [5] [43] The risk is greatest when the co-exposure is with impulse noise. [44] [45] Carbon monoxide has been shown to increase the severity of the hearing loss from noise. [43] Given the potential for enhanced risk of hearing loss, exposures and contact with products such as fuels, paint thinners, degreasers, white spirits, exhaust, should be kept to a minimum. [46] Noise exposures should be kept below 85 decibels, and the chemical exposures should be below the recommended exposure limits given by regulatory agencies.

Drug exposures mixed with noise potentially lead to increased risk of ototoxic hearing loss. Noise exposure combined with the chemotherapeutic cisplatin puts individuals at increased risk of ototoxic hearing loss. [34] Noise at 85 dB SPL or above added to the amount of hair cell death in the high frequency region of the cochlea in chinchillas. [47]

The hearing loss caused by chemicals can be very similar to a hearing loss caused by excessive noise. A 2018 informational bulletin by the US Occupational Safety and Health Administration (OSHA) and the National Institute for Occupational Safety and Health (NIOSH) introduces the issue, provides examples of ototoxic chemicals, lists the industries and occupations at risk and provides prevention information. [48]

Treatment

No specific treatment may be available, but withdrawal of the ototoxic drug may be warranted when the consequences of doing so are less severe than those of the ototoxicity. [6] Co-administration of anti-oxidants may limit the ototoxic effects. [34]

Ototoxic monitoring during exposure is recommended by the American Academy of Audiology to allow for proper detection and possible prevention or rehabilitation of the hearing loss through a cochlear implant or hearing aid. Monitoring can be completed through performing otoacoustic emissions testing or high frequency audiometry. Successful monitoring includes a baseline test before, or soon after, exposure to the ototoxicant. Follow-up testing is completed in increments after the first exposure, throughout the cessation of treatment. Shifts in hearing status are monitored and relayed to the prescribing physician to make treatment decisions. [49]

It is difficult to distinguish between nerve damage and structural damage due to similarity of the symptoms. Diagnosis of ototoxicity typically results from ruling out all other possible sources of hearing loss and is often the catchall explanation for the symptoms. Treatment options vary depending on the patient and the diagnosis. Some patients experience only temporary symptoms that do not require drastic treatment while others can be treated with medication. Physical therapy may prove useful for regaining balance and walking abilities. Cochlear implants are sometimes an option to restore hearing. Such treatments are typically taken to comfort the patient, not to cure the disease or damage caused by ototoxicity. There is no cure or restoration capability if the damage becomes permanent, [50] [51] although cochlear nerve terminal regeneration has been observed in chickens, [52] which suggests that there may be a way to accomplish this in humans.

Related Research Articles

<span class="mw-page-title-main">Hearing loss</span> Partial or total inability to hear

Hearing loss is a partial or total inability to hear. Hearing loss may be present at birth or acquired at any time afterwards. Hearing loss may occur in one or both ears. In children, hearing problems can affect the ability to acquire spoken language, and in adults it can create difficulties with social interaction and at work. Hearing loss can be temporary or permanent. Hearing loss related to age usually affects both ears and is due to cochlear hair cell loss. In some people, particularly older people, hearing loss can result in loneliness. Deaf people usually have little to no hearing.

<span class="mw-page-title-main">Ménière's disease</span> Disorder of the inner ear

Ménière's disease (MD) is a disease of the inner ear that is characterized by potentially severe and incapacitating episodes of vertigo, tinnitus, hearing loss, and a feeling of fullness in the ear. Typically, only one ear is affected initially, but over time, both ears may become involved. Episodes generally last from 20 minutes to a few hours. The time between episodes varies. The hearing loss and ringing in the ears can become constant over time.

Tinnitus is a variety of sound that is heard when no corresponding external sound is present. Nearly everyone experiences faint "normal tinnitus" in a completely quiet room; but it is of concern only if it is bothersome, interferes with normal hearing, or is associated with other problems. The word tinnitus comes from the Latin tinnire, "to ring". In some people, it interferes with concentration, and can be associated with anxiety and depression.

<span class="mw-page-title-main">Cochlea</span> Snail-shaped part of inner ear involved in hearing

The cochlea is the part of the inner ear involved in hearing. It is a spiral-shaped cavity in the bony labyrinth, in humans making 2.75 turns around its axis, the modiolus. A core component of the cochlea is the Organ of Corti, the sensory organ of hearing, which is distributed along the partition separating the fluid chambers in the coiled tapered tube of the cochlea.

<span class="mw-page-title-main">Gentamicin</span> Antibiotic medication

Gentamicin is an antibiotic used to treat several types of bacterial infections. This may include bone infections, endocarditis, pelvic inflammatory disease, meningitis, pneumonia, urinary tract infections, and sepsis among others. It is not effective for gonorrhea or chlamydia infections. It can be given intravenously, by intramuscular injection, or topically. Topical formulations may be used in burns or for infections of the outside of the eye. It is often only used for two days until bacterial cultures determine what specific antibiotics the infection is sensitive to. The dose required should be monitored by blood testing.

<span class="mw-page-title-main">Organ of Corti</span> Receptor organ for hearing

The organ of Corti, or spiral organ, is the receptor organ for hearing and is located in the mammalian cochlea. This highly varied strip of epithelial cells allows for transduction of auditory signals into nerve impulses' action potential. Transduction occurs through vibrations of structures in the inner ear causing displacement of cochlear fluid and movement of hair cells at the organ of Corti to produce electrochemical signals.

<span class="mw-page-title-main">Aminoglycoside</span> Antibacterial drug

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside (sugar). The term can also refer more generally to any organic molecule that contains amino sugar substructures. Aminoglycoside antibiotics display bactericidal activity against Gram-negative aerobes and some anaerobic bacilli where resistance has not yet arisen but generally not against Gram-positive and anaerobic Gram-negative bacteria.

<span class="mw-page-title-main">Sensorineural hearing loss</span> Hearing loss caused by an inner ear or vestibulocochlear nerve defect

Sensorineural hearing loss (SNHL) is a type of hearing loss in which the root cause lies in the inner ear or sensory organ or the vestibulocochlear nerve. SNHL accounts for about 90% of reported hearing loss. SNHL is usually permanent and can be mild, moderate, severe, profound, or total. Various other descriptors can be used depending on the shape of the audiogram, such as high frequency, low frequency, U-shaped, notched, peaked, or flat.

<span class="mw-page-title-main">Audiometry</span> Branch of audiology and the science of measuring hearing acuity

Audiometry is a branch of audiology and the science of measuring hearing acuity for variations in sound intensity and pitch and for tonal purity, involving thresholds and differing frequencies. Typically, audiometric tests determine a subject's hearing levels with the help of an audiometer, but may also measure ability to discriminate between different sound intensities, recognize pitch, or distinguish speech from background noise. Acoustic reflex and otoacoustic emissions may also be measured. Results of audiometric tests are used to diagnose hearing loss or diseases of the ear, and often make use of an audiogram.

Presbycusis, or age-related hearing loss, is the cumulative effect of aging on hearing. It is a progressive and irreversible bilateral symmetrical age-related sensorineural hearing loss resulting from degeneration of the cochlea or associated structures of the inner ear or auditory nerves. The hearing loss is most marked at higher frequencies. Hearing loss that accumulates with age but is caused by factors other than normal aging is not presbycusis, although differentiating the individual effects of distinct causes of hearing loss can be difficult.

<span class="mw-page-title-main">Noise-induced hearing loss</span> Medical condition

Noise-induced hearing loss (NIHL) is a hearing impairment resulting from exposure to loud sound. People may have a loss of perception of a narrow range of frequencies or impaired perception of sound including sensitivity to sound or ringing in the ears. When exposure to hazards such as noise occur at work and is associated with hearing loss, it is referred to as occupational hearing loss.

The semicircular canal dehiscence (SCD) is a category of rare neurotological diseases/disorders affecting the inner ears, which gathers the superior SCD, lateral SCD and posterior SCD. These SCDs induce SCD syndromes (SCDSs), which define specific sets of hearing and balance symptoms. This entry mainly deals with the superior SCDS.

Auditory fatigue is defined as a temporary loss of hearing after exposure to sound. This results in a temporary shift of the auditory threshold known as a temporary threshold shift (TTS). The damage can become permanent if sufficient recovery time is not allowed before continued sound exposure. When the hearing loss is rooted from a traumatic occurrence, it may be classified as noise-induced hearing loss, or NIHL.

<span class="mw-page-title-main">Vestibulocochlear dysfunction progressive familial</span> Medical condition

Vestibulocochlear dysfunction progressive familial, known also as familial progressive vestibulocochlear dysfunction is an autosomal dominant disease that results in sensorineural hearing loss and vestibular areflexia. Patients report feelings of vague dizziness, blurred vision, dysequilibrium in the dark, and progressive hearing impairment.

<span class="mw-page-title-main">Occupational hearing loss</span> Form of hearing loss

Occupational hearing loss (OHL) is hearing loss that occurs as a result of occupational hazards, such as excessive noise and ototoxic chemicals. Noise is a common workplace hazard, and recognized as the risk factor for noise-induced hearing loss and tinnitus but it is not the only risk factor that can result in a work-related hearing loss. Also, noise-induced hearing loss can result from exposures that are not restricted to the occupational setting.

Acoustic trauma is the sustainment of an injury to the eardrum as a result of a very loud noise. Its scope usually covers loud noises with a short duration, such as an explosion, gunshot or a burst of loud shouting. Quieter sounds that are concentrated in a narrow frequency may also cause damage to specific frequency receptors. The range of severity can vary from pain to hearing loss.

Sharon G. Kujawa is a clinical audiologist, Director of Audiology Research at the Massachusetts Eye and Ear Infirmary, Associate Professor of Otology and Laryngology at Harvard Medical School, and Adjunct Faculty of Harvard-MIT Health Sciences and Technology.and specialist in otolaryngology, Her specialty is the effects of noise exposure and aging on auditory function.

Causes of hearing loss include ageing, genetics, perinatal problems, loud sounds, and diseases. For some kinds of hearing loss the cause may be classified as of unknown cause.

Cochlear hydrops is a condition of the inner ear involving a pathological increase of fluid affecting the cochlea. This results in swelling that can lead to hearing loss or changes in hearing perception. It is a form of endolymphatic hydrops and related to Ménière's disease. Cochlear hydrops refers to a case of inner-ear hydrops that only involves auditory symptoms and does not cause vestibular issues.

<span class="mw-page-title-main">Ototoxic medication</span>

Ototoxicity is defined as the toxic effect on the functioning of the inner ear, which may lead to temporary or permanent hearing loss (cochleotoxic) and balancing problems (vestibulotoxic). Drugs or pharmaceutical agents inducing ototoxicity are regarded as ototoxic medications.

References

  1. ↑ Schacht J, Hawkins JE (2006-01-01). "Sketches of otohistory. Part 11: Ototoxicity: drug-induced hearing loss". Audiology and Neuro-Otology. 11 (1): 1–6. doi:10.1159/000088850. PMID   16219991. S2CID   37321714.
  2. ↑ Position Statement and Practice Guidelines on Ototoxicity Monitoring (PDF). American Academy of Audiology. 2009.
  3. ↑ Cazals Y (December 2000). "Auditory sensori-neural alterations induced by salicylate". Progress in Neurobiology. 62 (6): 583–631. doi:10.1016/s0301-0082(00)00027-7. PMID   10880852. S2CID   23196277.
  4. ↑ Jung, T. T.; Rhee, C. K.; Lee, C. S.; Park, Y. S.; Choi, D. C. (October 1993). "Ototoxicity of salicylate, nonsteroidal antiinflammatory drugs, and quinine". Otolaryngologic Clinics of North America. 26 (5): 791–810. doi:10.1016/S0030-6665(20)30767-2. ISSN   0030-6665. PMID   8233489.
  5. 1 2 3 Johnson AC, Morata TC (2010). "Occupational exposure to chemicals and hearing impairment. The Nordic Expert Group for Criteria Documentation of Health Risks from Chemicals" (PDF). Arbete och Hälsa. 44 (4): 177. Retrieved May 4, 2016.
  6. 1 2 3 4 5 6 7 8 9 10 11 12 Roland PS (2004). Ototoxicity. Hamilton, Ont: B.C. Decker. ISBN   978-1-55009-263-9.
  7. 1 2 "ototoxicity". The Free Dictionary by Farlex.
  8. 1 2 3 4 Mudd P. "Ototoxicity". Medscape Reference. WebMD LLC. Retrieved 30 Nov 2011.
  9. ↑ Dobie RA, Black FO, Pezsnecker SC, Stallings VL (March 2006). "Hearing loss in patients with vestibulotoxic reactions to gentamicin therapy". Archives of Otolaryngology–Head & Neck Surgery. 132 (3): 253–7. doi:10.1001/archotol.132.3.253. PMID   16549744.
  10. ↑ Basile AS, Huang JM, Xie C, Webster D, Berlin C, Skolnick P (December 1996). "N-methyl-D-aspartate antagonists limit aminoglycoside antibiotic-induced hearing loss". Nature Medicine. 2 (12): 1338–43. doi:10.1038/nm1296-1338. PMID   8946832. S2CID   30861122.
  11. ↑ Wu WJ, Sha SH, Schacht J (2002). "Recent advances in understanding aminoglycoside ototoxicity and its prevention". Audiology and Neuro-Otology. 7 (3): 171–4. doi:10.1159/000058305. PMID   12053140. S2CID   32139933.
  12. ↑ Munckhof WJ, Grayson ML, Turnidge JD (April 1996). "A meta-analysis of studies on the safety and efficacy of aminoglycosides given either once daily or as divided doses". The Journal of Antimicrobial Chemotherapy. 37 (4): 645–63. doi:10.1093/jac/37.4.645. PMID   8722531.
  13. ↑ Tepel M (August 2007). "N-Acetylcysteine in the prevention of ototoxicity". Kidney International. 72 (3): 231–2. doi: 10.1038/sj.ki.5002299 . PMID   17653228. S2CID   34339370.
  14. ↑ Wirmer J, Westhof E (2006). "Molecular contacts between antibiotics and the 30S ribosomal particle". Glycobiology. Methods in Enzymology. Vol. 415. pp. 180–202. doi:10.1016/S0076-6879(06)15012-0. ISBN   9780121828202. PMID   17116475.
  15. ↑ Esterberg R, Hailey DW, Coffin AB, Raible DW, Rubel EW (April 2013). "Disruption of intracellular calcium regulation is integral to aminoglycoside-induced hair cell death". The Journal of Neuroscience. 33 (17): 7513–25. doi:10.1523/JNEUROSCI.4559-12.2013. PMC   3703319 . PMID   23616556.
  16. ↑ Perez N, Martín E, García-Tapia R (March 2003). "Intratympanic gentamicin for intractable Meniere's disease". The Laryngoscope. 113 (3): 456–64. doi:10.1097/00005537-200303000-00013. PMID   12616197. S2CID   24159159.
  17. ↑ Voelker JR, Cartwright-Brown D, Anderson S, Leinfelder J, Sica DA, Kokko JP, Brater DC (October 1987). "Comparison of loop diuretics in patients with chronic renal insufficiency". Kidney International. 32 (4): 572–8. doi: 10.1038/ki.1987.246 . PMID   3430953.
  18. ↑ Schmitz PG (2012). Renal: An Integrated Approach to Disease. New York: McGraw-Hill. p. 123. ISBN   978-0-07-162155-7.
  19. ↑ Rademaker-Lakhai JM, Crul M, Zuur L, Baas P, Beijnen JH, Simis YJ, van Zandwijk N, Schellens JH (February 2006). "Relationship between cisplatin administration and the development of ototoxicity". Journal of Clinical Oncology. 24 (6): 918–24. doi: 10.1200/JCO.2006.10.077 . PMID   16484702.
  20. 1 2 Hellberg V, Wallin I, Eriksson S, Hernlund E, Jerremalm E, Berndtsson M, Eksborg S, Arnér ES, Shoshan M, Ehrsson H, Laurell G (January 2009). "Cisplatin and oxaliplatin toxicity: importance of cochlear kinetics as a determinant for ototoxicity". Journal of the National Cancer Institute. 101 (1): 37–47. doi:10.1093/jnci/djn418. PMC   2639295 . PMID   19116379.
  21. ↑ Bokemeyer C, Berger CC, Hartmann JT, Kollmannsberger C, Schmoll HJ, Kuczyk MA, Kanz L (April 1998). "Analysis of risk factors for cisplatin-induced ototoxicity in patients with testicular cancer". British Journal of Cancer. 77 (8): 1355–62. doi:10.1038/bjc.1998.226. PMC   2150148 . PMID   9579846.
  22. ↑ Li Y, Womer RB, Silber JH (November 2004). "Predicting cisplatin ototoxicity in children: the influence of age and the cumulative dose". European Journal of Cancer. 40 (16): 2445–51. doi:10.1016/j.ejca.2003.08.009. PMID   15519518.
  23. ↑ Callejo A, Sedó-Cabezón L, Juan ID, Llorens J (July 2015). "Cisplatin-Induced Ototoxicity: Effects, Mechanisms and Protection Strategies". Toxics. 3 (3): 268–293. doi: 10.3390/toxics3030268 . PMC   5606684 . PMID   29051464.
  24. ↑ Breglio AM, Rusheen AE, Shide ED, Fernandez KA, Spielbauer KK, McLachlin KM, Hall MD, Amable L, Cunningham LL (November 2017). "Cisplatin is retained in the cochlea indefinitely following chemotherapy". Nature Communications. 8 (1): 1654. Bibcode:2017NatCo...8.1654B. doi:10.1038/s41467-017-01837-1. PMC   5698400 . PMID   29162831.
  25. ↑ Rybak LP, Whitworth CA, Mukherjea D, Ramkumar V (April 2007). "Mechanisms of cisplatin-induced ototoxicity and prevention". Hearing Research. 226 (1–2): 157–67. doi:10.1016/j.heares.2006.09.015. PMID   17113254. S2CID   26537773.
  26. ↑ Hensley ML, Hagerty KL, Kewalramani T, Green DM, Meropol NJ, Wasserman TH, Cohen GI, Emami B, Gradishar WJ, Mitchell RB, Thigpen JT, Trotti A, von Hoff D, Schuchter LM (January 2009). "American Society of Clinical Oncology 2008 clinical practice guideline update: use of chemotherapy and radiation therapy protectants". Journal of Clinical Oncology. 27 (1): 127–45. doi:10.1200/JCO.2008.17.2627. PMID   19018081.
  27. ↑ van Der Heijden R, Jacobs DI, Snoeijer W, Hallard D, Verpoorte R (March 2004). "The Catharanthus alkaloids: pharmacognosy and biotechnology". Current Medicinal Chemistry. 11 (5): 607–28. doi:10.2174/0929867043455846. PMID   15032608.
  28. ↑ Raviña E (2011). "Vinca alkaloids". The evolution of drug discovery: From traditional medicines to modern drugs. John Wiley & Sons. pp. 157–159. ISBN   978-3-527-32669-3.
  29. ↑ Cooper R, Deakin JJ (2016). "Africa's gift to the world". Botanical Miracles: Chemistry of Plants That Changed the World. CRC Press. pp. 46–51. ISBN   978-1-4987-0430-4.
  30. ↑ Keglevich P, Hazai L, Kalaus G, Szántay C (May 2012). "Modifications on the basic skeletons of vinblastine and vincristine". Molecules. 17 (5): 5893–914. doi: 10.3390/molecules17055893 . PMC   6268133 . PMID   22609781.
  31. ↑ Bicknell, P. G. (1971). "Sensorineural deafness following myringoplasty operations". The Journal of Laryngology & Otology. 85 (9): 957–962. doi:10.1017/S0022215100074272. PMID   5571878. S2CID   45496227.
  32. ↑ "FDA Announces Revisions to Labels for Cialis, Levitra and Viagra. Potential risk of sudden hearing loss with ED drugs to be displayed more prominently". United States Food and Drug Administration. Archived from the original on 9 July 2009.
  33. ↑ Yafi FA, Sharlip ID, Becher EF (2017). "Update on the Safety of Phosphodiesterase Type 5 Inhibitors for the Treatment of Erectile Dysfunction". Sexual Medicine Reviews. 6 (2): 242–252. doi:10.1016/j.sxmr.2017.08.001. PMID   28923561.
  34. 1 2 3 Campbell K (2007). Pharmacology and Ototoxicity for Audiologists. Clifton Park, NY: Delmar Centrage Learning. p. 145. ISBN   978-1-4180-1130-7.
  35. ↑ Laurell G, Borg E (1986-01-01). "Cis-platin ototoxicity in previously noise-exposed guinea pigs". Acta Oto-Laryngologica. 101 (1–2): 66–74. doi:10.3109/00016488609108609. PMID   3962651.
  36. ↑ Rawool VW (2012). Hearing Conservation in Occupational, Recreational, Educational, and Home Settings. New York: Thieme. p. 13. ISBN   978-1-60406-256-4.
  37. ↑ Campo P, Morata TC, Hong O (April 2013). "Chemical exposure and hearing loss". Disease-a-Month. 59 (4): 119–38. doi:10.1016/j.disamonth.2013.01.003. PMC   4693596 . PMID   23507352.
  38. ↑ Rawool V (2012). Hearing Conservation: In Occupational, Recreational, Educational, and Home settings. New York, NY: Thieme. p. 10. ISBN   978-1-60406-256-4.
  39. ↑ Venet, Thomas; Carreres-Pons, Maria; Chalansonnet, Monique; Thomas, Aurélie; Merlen, Lise; Nunge, Hervé; Bonfanti, Elodie; Cosnier, Frédéric; Llorens, Jordi (2017-09-01). "Continuous exposure to low-frequency noise and carbon disulfide: Combined effects on hearing". NeuroToxicology. 62: 151–161. doi:10.1016/j.neuro.2017.06.013. ISSN   0161-813X. PMID   28655499. S2CID   10324339.
  40. ↑ Johnson, Ann-Christin; Morata, Thais C. (2009). The Nordic Expert Group for criteria documentation of health risks from chemicals. 142, Occupational exposure to chemicals and hearing impairment. Göteborg: University of Gothenburg. ISBN   9789185971213. OCLC   939229378.
  41. ↑ Lewkowski, Kate; Heyworth, Jane S.; Li, Ian W.; Williams, Warwick; McCausland, Kahlia; Gray, Corie; Ytterstad, Elinor; Glass, Deborah C.; Fuente, Adrian; Si, Si; Florath, Ines (2019). "Exposure to noise and ototoxic chemicals in the Australian workforce". Occupational and Environmental Medicine. 76 (5): 341–348. doi:10.1136/oemed-2018-105471. hdl: 20.500.11937/74587 . ISSN   1470-7926. PMID   30683670. S2CID   59275676.
  42. ↑ "Safety and Health Information Bulletins | Preventing Hearing Loss Caused by Chemical (Ototoxicity) and Noise Exposure | Occupational Safety and Health Administration". www.osha.gov. Retrieved 2020-04-15.
  43. 1 2 Fechter LD (2004). "Promotion of noise-induced hearing loss by chemical contaminants". Journal of Toxicology and Environmental Health. Part A. 67 (8–10): 727–40. doi:10.1080/15287390490428206. PMID   15192865. S2CID   5731842.
  44. ↑ Venet, Thomas; Campo, Pierre; Thomas, Aurélie; Cour, Chantal; Rieger, Benoît; Cosnier, Frédéric (2015). "The tonotopicity of styrene-induced hearing loss depends on the associated noise spectrum". Neurotoxicology and Teratology. 48: 56–63. doi:10.1016/j.ntt.2015.02.003. PMID   25689156.
  45. ↑ Fuente, Adrian; Qiu, Wei; Zhang, Meibian; Xie, Hongwei; Kardous, Chucri A.; Campo, Pierre; Morata, Thais C. (March 2018). "Use of the kurtosis statistic in an evaluation of the effects of noise and solvent exposures on the hearing thresholds of workers: An exploratory study" (PDF). The Journal of the Acoustical Society of America. 143 (3): 1704. Bibcode:2018ASAJ..143.1704F. doi:10.1121/1.5028368. ISSN   1520-8524. PMC   8588570 . PMID   29604694.
  46. ↑ "Preventing hearing loss caused by chemical (ototoxicity) and noise exposure". 2018-03-01. doi: 10.26616/nioshpub2018124 .{{cite journal}}: Cite journal requires |journal= (help)
  47. ↑ Gratton MA, Salvi RJ, Kamen BA, Saunders SS (1990). "Interaction of cisplatin and noise on the peripheral auditory system". Hearing Research. 50 (1–2): 211–23. doi:10.1016/0378-5955(90)90046-R. PMID   2076973. S2CID   4702189.
  48. ↑ "Preventing Hearing Loss Caused by Chemical (Ototoxicity) and Noise Exposure" (PDF). Occupational Safety and Health Administration, National Institute for Occupational Safety and Heath. April 3, 2018. Retrieved April 3, 2018.
  49. ↑ Durrant J (October 2009). "American Academy of Audiology Position Statement and Clinical Practice Guidelines: Ototoxic Monitoring" (PDF). American Academy of Audiology. Retrieved 4 December 2016.
  50. ↑ "Ototoxicity: Ear Poisoning". Causes of Deafness and Types of Deafness (Hearing Loss). My Deafness. Archived from the original on 10 December 2011. Retrieved 30 Nov 2011.
  51. ↑ VEDA-Vestibular Disorders Association https://web.archive.org/web/20060423050430/http://www.vestibular.org/vestibular-disorders/specific-disorders/ototoxicity.php. Archived from the original on April 23, 2006. Retrieved 30 Nov 2011.{{cite web}}: Missing or empty |title= (help)
  52. ↑ Hennig AK, Cotanche DA (1998). "Regeneration of cochlear efferent nerve terminals after gentamycin damage". The Journal of Neuroscience. 18 (9): 3282–96. doi: 10.1523/JNEUROSCI.18-09-03282.1998 . PMC   6792641 . PMID   9547237.
This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.