Podophyllum peltatum

Last updated

Mayapple
Podophyllum peltatum Arkansas.jpg
Podophyllum peltatum - Kohler-s Medizinal-Pflanzen-246.jpg
Podophyllum peltatum [1]
Status TNC G5.svg
Secure  (NatureServe)
Scientific classification OOjs UI icon edit-ltr.svg
Kingdom: Plantae
Clade: Tracheophytes
Clade: Angiosperms
Clade: Eudicots
Order: Ranunculales
Family: Berberidaceae
Genus: Podophyllum
Species:
P. peltatum
Binomial name
Podophyllum peltatum
L.
Podophyllum peltatum range map.png
Synonyms [2]
  • Anapodophyllum peltatumMoench

Podophyllum peltatum is an herbaceous perennial plant in the family Berberidaceae. Its common names are mayapple, American mandrake, wild mandrake, [3] and ground lemon. [4] It is widespread across most of the eastern United States and southeastern Canada. [5] [6]

Contents

Mayapples are woodland plants, typically growing in colonies derived from a single root. The stems grow to 30–40 cm (12 in to 16 in) tall, with palmately lobed umbrella-like leaves up to 20–40  cm (8 in to 16 in) diameter with 3–9 shallowly to deeply cut lobes. The plants produce several stems from a creeping underground rhizome; some stems bear a single leaf and do not produce any flower or fruit, while flowering stems produce a pair or more leaves with 1–8 flowers in the axil between the apical leaves. The flowers are white, yellow or red, 2–6 cm (1" to 2") diameter with 6–9 petals, and mature into a green, yellow or red fleshy fruit 2–5 cm (1 in to 2 in) long. [7]

All the parts of the plant are poisonous, including the green fruit, but once the fruit has turned yellow, it can be safely eaten. [8] The ripe fruit does not produce toxicity. [9]

The substance they contain (podophyllotoxin or podophyllin) is used as a purgative and as a cytostatic. Posalfilin is a drug containing podophyllin and salicylic acid that is used to treat the plantar wart. Podophyllotoxin is highly toxic if consumed.

They are also grown as ornamental plants for their attractive foliage and flowers, and they are a larval host for the golden borer moth and the may apple borer. [10]

Though the common name is mayapple, [11] in some areas it is the flower that appears in early May, not the "apple". The fruit or "apple" is usually produced early in summer and ripens later in summer.

Many species of plants have mycorrhizae to assist with nutrient uptake in infertile conditions. Mayapple plants are considered obligately dependent upon such mycorrhizae, although it may also be facultatively dependent upon rhizome age and soil nutrient levels. [12] Plants are commonly found infected by the rust Allodus podophylli , appearing as honeycomb-patterned orange colonies under the leaves, and yellowish lesions on the upper surface. [13] [14]

Toxicity and use

The unripe green fruit is toxic. The ripened yellow fruit is edible in small amounts, and sometimes made into jelly, [15] though when consumed in large amounts the fruit is poisonous. The rhizome, foliage, and roots are also poisonous. [16] Mayapple contains podophyllotoxin, [17] which is highly toxic if consumed, but can be used as a topical medicine.[ citation needed ]

Mayapple has been used by American Indians as an emetic, cathartic, [18] and antihelmintic agent. [18] The rhizome of the mayapple has been used for a variety of medicinal purposes, originally by indigenous inhabitants and later by other settlers.[ citation needed ]

Mayapple can be also used topically as an escharotic in removing warts, and two of its derivatives, etoposide and teniposide, have shown promise in treating some cancers. [19] [20] Etoposide is among the World Health Organisations's list of essential medicines [21] and it is derived from podophyllotoxin. [22]

Related Research Articles

<i>Aquilegia</i> Genus of perennial plants (columbine)

Aquilegia is a genus of about 60–70 species of perennial plants that are found in meadows, woodlands, and at higher altitudes throughout the Northern Hemisphere, known for the spurred petals of their flowers.

<i>Solanum carolinense</i> Species of plant

Solanum carolinense, the Carolina horsenettle, is not a true nettle, but a member of the Solanaceae, or nightshade family. It is a perennial herbaceous plant, native to the southeastern United States, though its range has expanded throughout much of temperate North America. The plant is an invasive in parts of Europe, Asia, and Australia. The stem and undersides of larger leaf veins are covered with prickles.

<i>Conium</i> Genus of flowering plants in the celery family Apiaceae

Conium is a genus of flowering plants in the family Apiaceae. As of December 2020, Plants of the World Online accepts six species.

<i>Strychnos nux-vomica</i> Species of plant

Strychnos nux-vomica, the strychnine tree, also known as nux vomica, poison fruit, semen strychnos, and quaker buttons, is a deciduous tree native to India and to southeast Asia. It is a medium-sized tree in the family Loganiaceae that grows in open habitats. Its leaves are ovate and 5–9 centimetres (2–3.5 in) in size. It is known for being the natural source of the extremely poisonous compound strychnine.

<i>Passiflora foetida</i> Species of carnivorous plant

Passiflora foetida is a species of passion flower that is native to the southwestern United States, Mexico, the Caribbean, Central America, and much of South America. It has been introduced to tropical regions around the world, such as Southeast Asia, South Asia, Hawaii, Africa, and The Maldives. It is a creeping vine like other members of the genus, and yields an edible fruit. The specific epithet, foetida, means "stinking" in Latin and refers to the strong aroma emitted by damaged foliage.

<span class="mw-page-title-main">Etoposide</span> Chemotherapy medication

Etoposide, sold under the brand name Vepesid among others, is a chemotherapy medication used for the treatments of a number of types of cancer including testicular cancer, lung cancer, lymphoma, leukemia, neuroblastoma, and ovarian cancer. It is also used for hemophagocytic lymphohistiocytosis. It is used by mouth or injection into a vein.

<i>Iris pseudacorus</i> Species of flowering plant in the iris family Iridaceae

Iris pseudacorus, the yellow flag, yellow iris, or water flag, is a species of flowering plant in the family Iridaceae. It is native to Europe, western Asia and northwest Africa. Its specific epithet pseudacorus means "false acorus", referring to the similarity of its leaves to those of Acorus calamus, as they have a prominently veined mid-rib and sword-like shape. However, the two plants are not closely related. The flower is commonly attributed with the fleur-de-lis.

<span class="mw-page-title-main">Teniposide</span> Chemical compound

Teniposide is a chemotherapeutic medication used in the treatment of childhood acute lymphocytic leukemia (ALL), Hodgkin's lymphoma, certain brain tumours, and other types of cancer. It is in a class of drugs known as podophyllotoxin derivatives and slows the growth of cancer cells in the body.

<span class="mw-page-title-main">Podophyllotoxin</span> Chemical compound

Podophyllotoxin (PPT) is the active ingredient in Podofilox, which is a medical cream that is used to treat genital warts and molluscum contagiosum. It is not recommended in HPV infections without external warts. It can be applied either by a healthcare provider or the person themselves.

<i>Iris versicolor</i> Species of plant

Iris versicolor is also commonly known as the blue flag, harlequin blueflag, larger blue flag, northern blue flag, and poison flag, plus other variations of these names, and in Britain and Ireland as purple iris.

<i>Jeffersonia</i> Genus of flowering plants belonging to the barberry family

Jeffersonia, also known as twinleaf or rheumatism root, is a small genus of herbaceous perennial plants in the family Berberidaceae. They are uncommon spring wildflowers and grow in limestone soils of rich deciduous forests. Jeffersonia was named for United States President Thomas Jefferson by his contemporary Benjamin Smith Barton. This genus was formerly grouped in genus Podophyllum. Twinleaf is protected by state laws as a threatened or endangered plant in Georgia, Iowa, New York, and New Jersey.

<i>Caulophyllum</i> Genus of flowering plants belonging to the barberry family

Caulophyllum is a small genus of perennial herbs belonging to the family Berberidaceae and closely related to the Eurasian genera Leontice and Gymnospermium. It is native to eastern Asia and eastern North America. These plants are distinctive spring wildflowers, which grow in moist, rich woodland, it is known for its large triple-compound leaf, and large blue, berry-like fruits. Unlike many spring wildflowers, it is not an ephemeral plant and persists throughout much of the summer. Common names for plants in this genus include blue cohosh, squaw root, and papoose root. As hinted at by its common names, this plant is well known as an alternative medicine for inducing childbirth and menstrual flow; it is also considered a poisonous plant.

<span class="mw-page-title-main">Epipodophyllotoxin</span>

Epipodophyllotoxins are substances naturally occurring in the root of American Mayapple plant.

<i>Ranzania japonica</i> Genus of flowering plants belonging to the barberry family

Ranzania is a monotypic genus of perennial herbs in the family Berberidaceae. The only species is Ranzania japonica. It is native to woodlands in the mountains of Honshu, Japan. This genus is named in honor of Ono Ranzan, who has been called "the Japanese Linnaeus". Fleshy stems of Ranzania form small colonies from an underground rhizome. Each stem bears two trifoliate compound leaves, and between the leaves is a single or more commonly a small cluster of drooping cup-shaped mauve flowers. These develop into an upright cluster of white berries. The haploid chromosome number is n=7.

<i>Bryonia alba</i> Species of plant

Bryonia alba is a vigorous vine in the family Cucurbitaceae, found in Europe and Northern Iran. It has a growth habit similar to kudzu, which gives it a highly destructive potential outside its native range as a noxious weed. Other common names include false mandrake, English mandrake, wild vine, and wild hops, wild nep, tamus, ladies' seal, and tetterbury.

<span class="mw-page-title-main">Plant sources of anti-cancer agents</span>

Plant sources of anti-cancer agents are plants, the derivatives of which have been shown to be usable for the treatment or prevention of cancer in humans.

<i>Bergenia crassifolia</i> Species of flowering plant

Bergenia crassifolia is a species of flowering plant of the genus Bergenia in the family Saxifragaceae. Common names for the species include heart-leaved bergenia, heartleaf bergenia, leather bergenia, winter-blooming bergenia, elephant-ears, elephant's ears, Korean elephant-ear, badan, pigsqueak, Siberian tea, and Mongolian tea.

<i>Sinopodophyllum</i> Genus of flowering plants belonging to the barberry family

Sinopodophyllum is an herbaceous perennial plant in the family Berberidaceae, described as a genus in 1979. It includes only one known species, Sinopodophyllum hexandrum, native to Afghanistan, Bhutan, northern India, Kashmir, Nepal, Pakistan, and western China. Common names include Himalayan may apple and Indian may apple.

<i>Stellera</i> Genus of flowering plants

Stellera is a genus of flowering plant in the family Thymelaeaceae, with a single species Stellera chamaejasme found in mountainous regions of Central Asia, China, Siberia and South Asia. S. chamaejasme is a herbaceous perennial plant with heads of white, pink or yellow flowers, grown as an ornamental plant in rock gardens and alpine houses, but considered a weed playing a rôle in the desertification of grasslands in parts of its native range. Like many others of its family, it is a poisonous plant with medicinal and other useful properties.

<i>Podophyllum pleianthum</i> Species of plant in the genus Podophyllum

Podophyllum pleianthum, the many-flowered Chinese mayapple, is a species of flowering plant in the genus Podophyllum, native to south-central and southeast China, including Taiwan. Shade tolerant, and deer resistant due to its toxicity, it has gained the Royal Horticultural Society's Award of Garden Merit.

References

  1. 1896 illustration from Franz Eugen Köhler, Köhler's Medizinal-Pflanzen
  2. The Plant List, Podophyllum peltatum L.
  3. "Podophyllum peltatum". Germplasm Resources Information Network . Agricultural Research Service, United States Department of Agriculture . Retrieved 28 March 2015.
  4. Plants for a Future , retrieved 28 March 2015
  5. "Podophyllum L.". Integrated Taxonomic Information System.
  6. Biota of North America Program 2013 county distribution map
  7. Flora of North America, Vol. 3, Podophyllum Linnaeus
  8. "Mayapple, Mandrake". 31 August 2011.
  9. PubChem. "Podophyllotoxin". pubchem.ncbi.nlm.nih.gov. Retrieved 2020-04-25.
  10. Bess, James (2005). "Conservation Assessment for the mayapple borer moth (Papaipema rutila (Guenee))" (PDF). United States Forest Service. Retrieved 27 September 2019.
  11. Podophyllum peltatum at USDA PLANTS Database
  12. Watson, M.A. and five others. 2001. The developmental ecology of mycorrhizal associations in mayapple, Podophyllum peltatum, Berberidaceae. Evolutionary Ecology 15: 425–442.
  13. "Puccinia podophyllin Schwein. Mayapple rust". Iowa State University, Ada Hayden Herbarium (ISC). Retrieved 2013-03-16.
  14. Bunyard, Britt A. 2013 "Mayapple Rust Resurrection" FUNGI 6(1): 38–39.
  15. Niering, William A.; Olmstead, Nancy C. (1985) [1979]. The Audubon Society Field Guide to North American Wildflowers, Eastern Region. Knopf. p. 418. ISBN   0-394-50432-1.
  16. Blanchan, Neltje (2002). Wild Flowers: An Aid to Knowledge of our Wild Flowers and their Insect Visitors. Project Gutenberg Literary Archive Foundation.
  17. Moraes, R.M., H. Lata, E. Bedir, M. Maqbool, and K. Cushman. 2002. On American Mayapple as a practical source of podophyllotoxin p. 527–532. In: J. Janick and A. Whipkey (eds.), Trends in new crops and new uses. ASHS Press, Alexandria, VA.
  18. 1 2 Ernest Small and Paul M. Catling (1999), "Podophyllum peltatum L. (May-apple)", Canadian Medicinal Crops, NRC Research Press
  19. Brunton LL et al. Goodman and Gilman's The Pharmacological Basis of Therapeutics, chapter: 61. Cytotoxic agents/Epipodophyllotoxins Twelfth Edition ISBN   978-0-07-162442-8
  20. Lewis, W.H. and M.P.F. Elvin-Lewis. 1977. Medical Botany. Plants Affecting Man's Health. Wiley, New York. 515 p. p. 123-124.
  21. "22nd Essential Medicines List". World Health Organization. Retrieved 22 September 2022.
  22. "PubChem". National Library of Medicine. Retrieved 22 September 2022.