Related Research Articles
Retromer is a complex of proteins that has been shown to be important in recycling transmembrane receptors from endosomes to the trans-Golgi network (TGN).
The PX domain is a phosphoinositide-binding structural domain involved in targeting of proteins to cell membranes.
Sorting nexin-1 is a protein that in humans is encoded by the SNX1 gene. The protein encoded by this gene is a sorting nexin. SNX1 is a component of the retromer complex.
Proto-oncogene serine/threonine-protein kinase Pim-1 is an enzyme that in humans is encoded by the PIM1 gene.
Vacuolar protein sorting-associated protein 35 is a protein that in humans is encoded by the VPS35 gene.
Sorting nexin-9 is a protein that in humans is encoded by the SNX9 gene.
Sorting nexin-2 is a protein that in humans is encoded by the SNX2 gene.
Vacuolar protein sorting-associated protein 26A is a protein that in humans is encoded by the VPS26A gene.
Sorting nexin-17 is a protein that in humans is encoded by the SNX17 gene.
Sorting nexin-5 is a protein that in humans is encoded by the SNX5 gene.
Sorting nexin-3 is a protein that in humans is encoded by the SNX3 gene.
Sorting nexin family member 27, also known as SNX27, is a human gene.
Sorting nexin-13 is a protein that in humans is encoded by the SNX13 gene.
Sorting nexin-15 is a protein that in humans is encoded by the SNX15 gene.
Sorting nexin-4 is a protein that in humans is encoded by the SNX4 gene.
Sorting nexin-21 is a protein that in humans is encoded by the SNX21 gene.
Sorting nexin-18 is a protein that in humans is encoded by the SNX18 gene.
Sorting nexins are a large group of proteins that are localized in the cytoplasm and have the potential for membrane association either through their lipid-binding PX domain or through protein–protein interactions with membrane-associated protein complexes Some members of this family have been shown to facilitate protein sorting.
Sorting nexin 10 is a protein that in humans is encoded by the SNX10 gene.
The SNX8 is a sorting nexin protein involved in intracelullar molecular traffic from the early endosomes to the TGN. It is suggested that it acts as an adaptor protein in events related to immune response and cholesterol regulation, for example. As a protein of the SNXs family, the SNX8 is formed of 465 aminoacids and presents a BAR-domain and a PX-domain which are very relevant in relation to its functions. Furthermore, SNX8 study is motivated by its medical significance in relation to diseases such as Alzheimer's Disease, cancer, neurodevelopmental malformations and to its role in fighting against viral infections.
References
- ↑ Wassmer T, Attar N, Bujny MV, Oakley J, Traer CJ, Cullen PJ (January 2007). "A loss-of-function screen reveals SNX5 and SNX6 as potential components of the mammalian retromer". J. Cell Sci. 120 (Pt 1): 45–54. doi: 10.1242/jcs.03302 . PMID 17148574.
- ↑ Parks WT, Frank DB, Huff C, Renfrew Haft C, Martin J, Meng X, de Caestecker MP, McNally JG, Reddi A, Taylor SI, Roberts AB, Wang T, Lechleider RJ (June 2001). "Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases". J. Biol. Chem. 276 (22): 19332–9. doi: 10.1074/jbc.M100606200 . PMID 11279102.
- ↑ Ishibashi Y, Maita H, Yano M, Koike N, Tamai K, Ariga H, Iguchi-Ariga SM (September 2001). "Pim-1 translocates sorting nexin 6/TRAF4-associated factor 2 from cytoplasm to nucleus". FEBS Lett. 506 (1): 33–8. doi:10.1016/S0014-5793(01)02881-2. PMID 11591366.
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