SNX1

Last updated
SNX1
PDB 2i4k EBI.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases SNX1 , HsT17379, VPS5, sorting nexin 1
External IDs OMIM: 601272 MGI: 1928395 HomoloGene: 99716 GeneCards: SNX1
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001242933
NM_003099
NM_148955
NM_152826

NM_019727

RefSeq (protein)

NP_001229862
NP_003090
NP_683758

NP_062701

Location (UCSC) Chr 15: 64.09 – 64.15 Mb Chr 9: 66 – 66.03 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Sorting nexin-1 is a protein that in humans is encoded by the SNX1 gene. The protein encoded by this gene is a sorting nexin. [5] SNX1 is a component of the retromer complex. [6] [7]

Contents

Function

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This endosomal protein regulates the cell-surface expression of epidermal growth factor receptor. This protein also has a role in sorting protease-activated receptor-1 from early endosomes to lysosomes. This protein may form oligomeric complexes with other family members. [8]

Related Research Articles

<span class="mw-page-title-main">Endosome</span> Vacuole to which materials ingested by endocytosis are delivered

Endosomes are a collection of intracellular sorting organelles in eukaryotic cells. They are parts of endocytic membrane transport pathway originating from the trans Golgi network. Molecules or ligands internalized from the plasma membrane can follow this pathway all the way to lysosomes for degradation or can be recycled back to the cell membrane in the endocytic cycle. Molecules are also transported to endosomes from the trans Golgi network and either continue to lysosomes or recycle back to the Golgi apparatus.

Retromer is a complex of proteins that has been shown to be important in recycling transmembrane receptors from endosomes to the trans-Golgi network (TGN) and directly back to the plasma membrane. Mutations in retromer and its associated proteins have been linked to Alzheimer's and Parkinson's diseases.

<span class="mw-page-title-main">SORL1</span> Protein-coding gene in the species Homo sapiens

Sortilin-related receptor, L(DLR class) A repeats containing is a protein that in humans is encoded by the SORL1 gene.

<span class="mw-page-title-main">HGS (gene)</span> Protein-coding gene in the species Homo sapiens

Hepatocyte growth factor-regulated tyrosine kinase substrate is an enzyme that in humans is encoded by the HGS gene.

<span class="mw-page-title-main">SNX9</span> Protein-coding gene in the species Homo sapiens

Sorting nexin-9 is a protein that in humans is encoded by the SNX9 gene.

<span class="mw-page-title-main">SNX2</span> Protein-coding gene in the species Homo sapiens

Sorting nexin-2 is a protein that in humans is encoded by the SNX2 gene.

<span class="mw-page-title-main">VPS26A</span> Protein-coding gene in the species Homo sapiens

Vacuolar protein sorting-associated protein 26A is a protein that in humans is encoded by the VPS26A gene.

<span class="mw-page-title-main">SNX17</span> Protein-coding gene in the species Homo sapiens

Sorting nexin-17 is a protein that in humans is encoded by the SNX17 gene.

<span class="mw-page-title-main">STAB1</span> Protein-coding gene in the species Homo sapiens

Stabilin-1 is a protein that in humans is encoded by the STAB1 gene.

<span class="mw-page-title-main">VPS29</span> Protein-coding gene in the species Homo sapiens

VPS29 is a human gene coding for the vacuolar protein sorting protein Vps29, a component of the retromer complex.

<span class="mw-page-title-main">SNX5</span> Protein-coding gene in the species Homo sapiens

Sorting nexin-5 is a protein that in humans is encoded by the SNX5 gene.

<span class="mw-page-title-main">SNX26</span> Protein-coding gene in the species Homo sapiens

TC10/CDC42 GTPase-activating protein is an enzyme that in humans is encoded by the SNX26 gene.

<span class="mw-page-title-main">SNX3</span> Protein-coding gene in the species Homo sapiens

Sorting nexin-3 is a protein that in humans is encoded by the SNX3 gene.

<span class="mw-page-title-main">SNX15</span> Protein-coding gene in the species Homo sapiens

Sorting nexin-15 is a protein that in humans is encoded by the SNX15 gene.

<span class="mw-page-title-main">VPS25</span> Protein-coding gene in the species Homo sapiens

Vacuolar protein-sorting-associated protein 25 is a protein that in humans is encoded by the VPS25 gene.

<span class="mw-page-title-main">SNX4</span> Protein-coding gene in the species Homo sapiens

Sorting nexin-4 is a protein that in humans is encoded by the SNX4 gene.

<span class="mw-page-title-main">SNX21</span> Protein-coding gene in the species Homo sapiens

Sorting nexin-21 is a protein that in humans is encoded by the SNX21 gene.

<span class="mw-page-title-main">SNAG1</span> Protein-coding gene in the species Homo sapiens

Sorting nexin-18 is a protein that in humans is encoded by the SNX18 gene.

<span class="mw-page-title-main">Cation-dependent mannose-6-phosphate receptor</span> Protein-coding gene in the species Homo sapiens

In the fields of biochemistry and cell biology, the cation-dependent mannose-6-phosphate receptor (CD-MPR) also known as the 46 kDa mannose 6-phosphate receptor is a protein that in humans is encoded by the M6PR gene.

<span class="mw-page-title-main">SNX8</span> Protein

The SNX8 is a sorting nexin protein involved in intracellular molecular traffic from the early endosomes to the TGN. It is suggested that it acts as an adaptor protein in events related to immune response and cholesterol regulation, for example. As a protein of the SNXs family, the SNX8 is formed of 465 aminoacids and presents a BAR-domain and a PX-domain which are very relevant in relation to its functions. Furthermore, SNX8 study is motivated by its medical significance in relation to diseases such as Alzheimer's Disease, cancer, neurodevelopmental malformations and to its role in fighting against viral infections.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000028528 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032382 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Kurten RC, Cadena DL, Gill GN (May 1996). "Enhanced degradation of EGF receptors by a sorting nexin, SNX1". Science. 272 (5264): 1008–10. Bibcode:1996Sci...272.1008K. doi:10.1126/science.272.5264.1008. PMID   8638121. S2CID   42608043.
  6. Vergés M (2008). Retromer: multipurpose sorting and specialization in polarized transport. International Review of Cell and Molecular Biology. Vol. 271. pp. 153–98. doi:10.1016/S1937-6448(08)01204-5. ISBN   9780123747280. PMID   19081543.{{cite book}}: |journal= ignored (help)
  7. Bonifacino JS, Hurley JH (August 2008). "Retromer". Curr. Opin. Cell Biol. 20 (4): 427–36. doi:10.1016/j.ceb.2008.03.009. PMC   2833274 . PMID   18472259.
  8. "Entrez Gene: sorting nexin 1".

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.