SNX1 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | SNX1 , HsT17379, VPS5, sorting nexin 1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 601272 MGI: 1928395 HomoloGene: 99716 GeneCards: SNX1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Sorting nexin-1 is a protein that in humans is encoded by the SNX1 gene. The protein encoded by this gene is a sorting nexin. [5] SNX1 is a component of the retromer complex. [6] [7]
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This endosomal protein regulates the cell-surface expression of epidermal growth factor receptor. This protein also has a role in sorting protease-activated receptor-1 from early endosomes to lysosomes. This protein may form oligomeric complexes with other family members. [8]
Endosomes are a collection of intracellular sorting organelles in eukaryotic cells. They are parts of endocytic membrane transport pathway originating from the trans Golgi network. Molecules or ligands internalized from the plasma membrane can follow this pathway all the way to lysosomes for degradation or can be recycled back to the cell membrane in the endocytic cycle. Molecules are also transported to endosomes from the trans Golgi network and either continue to lysosomes or recycle back to the Golgi apparatus.
Retromer is a complex of proteins that has been shown to be important in recycling transmembrane receptors from endosomes to the trans-Golgi network (TGN) and directly back to the plasma membrane. Mutations in retromer and its associated proteins have been linked to Alzheimer's and Parkinson's diseases.
Sortilin-related receptor, L(DLR class) A repeats containing is a protein that in humans is encoded by the SORL1 gene.
Hepatocyte growth factor-regulated tyrosine kinase substrate is an enzyme that in humans is encoded by the HGS gene.
Sorting nexin-9 is a protein that in humans is encoded by the SNX9 gene.
Sorting nexin-2 is a protein that in humans is encoded by the SNX2 gene.
Vacuolar protein sorting-associated protein 26A is a protein that in humans is encoded by the VPS26A gene.
Sorting nexin-17 is a protein that in humans is encoded by the SNX17 gene.
Stabilin-1 is a protein that in humans is encoded by the STAB1 gene.
VPS29 is a human gene coding for the vacuolar protein sorting protein Vps29, a component of the retromer complex.
Sorting nexin-5 is a protein that in humans is encoded by the SNX5 gene.
TC10/CDC42 GTPase-activating protein is an enzyme that in humans is encoded by the SNX26 gene.
Sorting nexin-3 is a protein that in humans is encoded by the SNX3 gene.
Sorting nexin-15 is a protein that in humans is encoded by the SNX15 gene.
Vacuolar protein-sorting-associated protein 25 is a protein that in humans is encoded by the VPS25 gene.
Sorting nexin-4 is a protein that in humans is encoded by the SNX4 gene.
Sorting nexin-21 is a protein that in humans is encoded by the SNX21 gene.
Sorting nexin-18 is a protein that in humans is encoded by the SNX18 gene.
In the fields of biochemistry and cell biology, the cation-dependent mannose-6-phosphate receptor (CD-MPR) also known as the 46 kDa mannose 6-phosphate receptor is a protein that in humans is encoded by the M6PR gene.
The SNX8 is a sorting nexin protein involved in intracellular molecular traffic from the early endosomes to the TGN. It is suggested that it acts as an adaptor protein in events related to immune response and cholesterol regulation, for example. As a protein of the SNXs family, the SNX8 is formed of 465 aminoacids and presents a BAR-domain and a PX-domain which are very relevant in relation to its functions. Furthermore, SNX8 study is motivated by its medical significance in relation to diseases such as Alzheimer's Disease, cancer, neurodevelopmental malformations and to its role in fighting against viral infections.
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ignored (help)This article incorporates text from the United States National Library of Medicine, which is in the public domain.