SNX3

SNX3
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2YPS, 2MXC
Identifiers
Aliases	SNX3 , Grd19, MCOPS8, SDP3, sorting nexin 3
External IDs	OMIM: 605930 MGI: 1860188 HomoloGene: 36144 GeneCards: SNX3
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6q21 Start 108,211,222 bp [1] End 108,261,246 bp [1]
Gene location (Mouse) Chr. Chromosome 10 (mouse) [2] Band 10 B2|10 22.89 cM Start 42,378,026 bp [2] End 42,411,377 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cancellous bone middle temporal gyrus visceral pleura parietal pleura endothelial cell right ventricle germinal epithelium parotid gland Brodmann area 23 Brodmann area 46 Top expressed in pyloric antrum yolk sac calvaria plantaris muscle facial motor nucleus entorhinal cortex interventricular septum extraocular muscle Epithelium of stomach anterior horn of spinal cord More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphatidylinositol-3-phosphate binding phosphatidylinositol-3,5-bisphosphate binding phosphatidylinositol-4-phosphate binding phosphatidylinositol-5-phosphate binding protein binding phosphatidylinositol binding protein phosphatase binding lipid binding phosphatidylinositol phosphate binding Cellular component cytoplasm cytosol endosome early endosome membrane early phagosome retromer complex early endosome phagocytic vesicle extracellular exosome cytoplasmic vesicle clathrin-coated vesicle extrinsic component of membrane endosome membrane Biological process protein to membrane docking negative regulation of viral entry into host cell negative regulation of phagocytosis response to bacterium negative regulation of protein catabolic process negative regulation of early endosome to late endosome transport membrane invagination regulation of Wnt signaling pathway intralumenal vesicle formation negative regulation of protein transport positive regulation of neuron projection development protein transport Wnt signaling pathway protein deubiquitination transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8724 54198 Ensembl ENSG00000112335 ENSMUSG00000019804 UniProt O60493 O70492 RefSeq (mRNA) NM_152828 NM_001300928 NM_001300929 NM_003795 NM_152827 NM_017472 RefSeq (protein) NP_001287857 NP_001287858 NP_003786 NP_690040 n/a Location (UCSC) Chr 6: 108.21 – 108.26 Mb Chr 10: 42.38 – 42.41 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Sorting nexin-3 is a protein that in humans is encoded by the SNX3 gene. ^{[5] [6]}

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like most family members. This protein interacts with phosphatidylinositol-3-phosphate, and is involved in protein trafficking. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000112335 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000019804 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Haft CR, de la Luz Sierra M, Barr VA, Haft DH, Taylor SI (Dec 1998). "Identification of a Family of Sorting Nexin Molecules and Characterization of Their Association with Receptors". Mol Cell Biol. 18 (12): 7278–87. doi:10.1128/mcb.18.12.7278. PMC   109309 . PMID   9819414.
6. "Entrez Gene: SNX3 sorting nexin 3".

Further reading

• Parks WT, Frank DB, Huff C, et al. (2001). "Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases". J. Biol. Chem. 276 (22): 19332–9. doi: 10.1074/jbc.M100606200 . PMID   11279102.
• Xu Y, Hortsman H, Seet L, et al. (2001). "SNX3 regulates endosomal function through its PX-domain-mediated interaction with PtdIns(3)P". Nat. Cell Biol. 3 (7): 658–66. doi:10.1038/35083051. PMID   11433298. S2CID   32893219.
• Vervoort VS, Viljoen D, Smart R, et al. (2003). "Sorting nexin 3 (SNX3) is disrupted in a patient with a translocation t(6;13)(q21;q12) and microcephaly, microphthalmia, ectrodactyly, prognathism (MMEP) phenotype". J. Med. Genet. 39 (12): 893–9. doi:10.1136/jmg.39.12.893. PMC   1757218 . PMID   12471201.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID   12665801. S2CID   23783563.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi: 10.1038/nature02055 . PMID   14574404.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID   16964243. S2CID   14294292.
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi: 10.1016/j.cell.2006.09.026 . PMID   17081983. S2CID   7827573.
• Kumar RA, Everman DB, Morgan CT, et al. (2007). "Absence of mutations in NR2E1 and SNX3 in five patients with MMEP (microcephaly, microphthalmia, ectrodactyly, and prognathism) and related phenotypes". BMC Med. Genet. 8: 48. doi:10.1186/1471-2350-8-48. PMC   1950490 . PMID   17655765.