SNX27

SNX27
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4HAS
Identifiers
Aliases	SNX27 , MRT1, MY014, sorting nexin family member 27, sorting nexin 27
External IDs	OMIM: 611541 MGI: 1923992 HomoloGene: 12797 GeneCards: SNX27
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q21.3 Start 151,612,006 bp [1] End 151,699,091 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3|3 F2.1 Start 94,404,851 bp [2] End 94,490,023 bp [2]
RNA expression pattern Bgee Top expressed in pituitary gland putamen corpus callosum occipital lobe cerebellum internal globus pallidus subthalamic nucleus cerebral cortex nucleus accumbens mesencephalon More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphatidylinositol-3-phosphate binding GO:0001948 protein binding phosphatidylinositol binding lipid binding Cellular component early endosome membrane membrane nucleoplasm retromer complex early endosome immunological synapse WASH complex cytoplasm endosome cytosol Biological process establishment of natural killer cell polarity endosome to lysosome transport endosomal transport protein transport intracellular protein transport signal transduction Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	81609	76742
Ensembl	ENSG00000143376	ENSMUSG00000028136
UniProt	Q96L92	Q3UHD6
RefSeq (mRNA)	NM_030918 NM_001330723	NM_001082484 NM_029721
RefSeq (protein)	NP_001317652 NP_112180	NP_001075953 NP_083997
Location (UCSC)	Chr 1: 151.61 – 151.7 Mb	Chr 3: 94.4 – 94.49 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Sorting nexin family member 27, also known as SNX27, is a human gene. ^[5]

This gene encodes a member of the sorting nexin family, a diverse group of cytoplasmic and membrane-associated proteins involved in endocytosis of plasma membrane receptors and protein trafficking through these compartments. All members of this protein family contain a phosphoinositide binding domain (PX domain). A highly similar protein in mice is responsible for the specific recruitment of an isoform of the serotonin 5-hydroxytryptamine 4 receptor into early endosomes, suggesting the analogous role for the human protein. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000143376 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028136 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: SNX27 sorting nexin family member 27".

Further reading

• Worby CA, Dixon JE (December 2002). "Sorting out the cellular functions of sorting nexins". Nature Reviews. Molecular Cell Biology. 3 (12): 919–31. doi:10.1038/nrm974. PMID   12461558. S2CID   36361630.
• Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Seki N, Ohira M, Nagase T, Ishikawa K, Miyajima N, Nakajima D, Nomura N, Ohara O (October 1997). "Characterization of cDNA clones in size-fractionated cDNA libraries from human brain". DNA Research. 4 (5): 345–9. doi: 10.1093/dnares/4.5.345 . PMID   9455484.
• Teasdale RD, Loci D, Houghton F, Karlsson L, Gleeson PA (August 2001). "A large family of endosome-localized proteins related to sorting nexin 1". The Biochemical Journal. 358 (Pt 1): 7–16. doi:10.1042/0264-6021:3580007. PMC   1222026 . PMID   11485546.
• Williams R, Schlüter T, Roberts MS, Knauth P, Bohnensack R, Cutler DF (July 2004). "Sorting nexin 17 accelerates internalization yet retards degradation of P-selectin". Molecular Biology of the Cell. 15 (7): 3095–105. doi:10.1091/mbc.E04-02-0143. PMC   452567 . PMID   15121882.
• Joubert L, Hanson B, Barthet G, Sebben M, Claeysen S, Hong W, Marin P, Dumuis A, Bockaert J (October 2004). "New sorting nexin (SNX27) and NHERF specifically interact with the 5-HT4a receptor splice variant: roles in receptor targeting". Journal of Cell Science. 117 (Pt 22): 5367–79. doi: 10.1242/jcs.01379 . PMID   15466885.
• Rincón E, Santos T, Avila-Flores A, Albar JP, Lalioti V, Lei C, Hong W, Mérida I (June 2007). "Proteomics identification of sorting nexin 27 as a diacylglycerol kinase zeta-associated protein: new diacylglycerol kinase roles in endocytic recycling". Molecular & Cellular Proteomics. 6 (6): 1073–87. doi: 10.1074/mcp.M700047-MCP200 . PMID   17351151.
• MacNeil AJ, Mansour M, Pohajdak B (August 2007). "Sorting nexin 27 interacts with the Cytohesin associated scaffolding protein (CASP) in lymphocytes". Biochemical and Biophysical Research Communications. 359 (4): 848–53. doi:10.1016/j.bbrc.2007.05.162. PMID   17577583.