SNX2

Last updated
SNX2
Identifiers
Aliases SNX2 , TRG-9, sorting nexin 2
External IDs OMIM: 605929 MGI: 1915054 HomoloGene: 2332 GeneCards: SNX2
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003100
NM_001278199

NM_026386
NM_001357463

RefSeq (protein)

NP_001265128
NP_003091

NP_080662
NP_001344392

Location (UCSC) Chr 5: 122.78 – 122.83 Mb Chr 18: 53.31 – 53.35 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Sorting nexin-2 is a protein that in humans is encoded by the SNX2 gene. [5] [6]

Contents

Function

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associates with formin-binding protein 17, but its function is unknown. This protein may form oligomeric complexes with family members. [6]

Interactions

SNX2 has been shown to interact with FNBP1. [7] [8]

Related Research Articles

<span class="mw-page-title-main">Retromer</span>

Retromer is a complex of proteins that has been shown to be important in recycling transmembrane receptors from endosomes to the trans-Golgi network (TGN) and directly back to the plasma membrane. Mutations in retromer and its associated proteins have been linked to Alzheimer's and Parkinson's diseases.

<span class="mw-page-title-main">SORL1</span> Protein-coding gene in the species Homo sapiens

Sortilin-related receptor, L(DLR class) A repeats containing is a protein that in humans is encoded by the SORL1 gene.

<span class="mw-page-title-main">SNX1</span> Protein-coding gene in the species Homo sapiens

Sorting nexin-1 is a protein that in humans is encoded by the SNX1 gene. The protein encoded by this gene is a sorting nexin. SNX1 is a component of the retromer complex.

<span class="mw-page-title-main">HGS (gene)</span> Protein-coding gene in the species Homo sapiens

Hepatocyte growth factor-regulated tyrosine kinase substrate is an enzyme that in humans is encoded by the HGS gene.

<span class="mw-page-title-main">Perilipin-3</span> Protein-coding gene in the species Homo sapiens

Mannose-6-phosphate receptor binding protein 1 (M6PRBP1) is a protein which in humans is encoded by the M6PRBP1 gene. Its gene product, as well as the gene itself, is commonly known as TIP47.

<span class="mw-page-title-main">Tankyrase</span> Enzyme

Tankyrase, also known as tankyrase 1, is an enzyme that in humans is encoded by the TNKS gene. It inhibits the binding of TERF1 to telomeric DNA. Tankyrase attracts substantial interest in cancer research through its interaction with AXIN1 and AXIN2, which are negative regulators of pro-oncogenic β-catenin signaling. Importantly, activity in the β-catenin destruction complex can be increased by tankyrase inhibitors and thus such inhibitors are a potential therapeutic option to reduce the growth of β-catenin-dependent cancers.

<span class="mw-page-title-main">FNBP1</span> Protein-coding gene in the species Homo sapiens

Formin-binding protein 1 is a protein that in humans is encoded by the FNBP1 gene.

<span class="mw-page-title-main">SNX9</span> Protein-coding gene in the species Homo sapiens

Sorting nexin-9 is a protein that in humans is encoded by the SNX9 gene.

<span class="mw-page-title-main">VPS26A</span> Protein-coding gene in the species Homo sapiens

Vacuolar protein sorting-associated protein 26A is a protein that in humans is encoded by the VPS26A gene.

<span class="mw-page-title-main">SNX17</span> Protein-coding gene in the species Homo sapiens

Sorting nexin-17 is a protein that in humans is encoded by the SNX17 gene.

<span class="mw-page-title-main">RAB11FIP5</span> Protein-coding gene in the species Homo sapiens

Rab11 family-interacting protein 5 is a protein that in humans is encoded by the RAB11FIP5 gene.

<span class="mw-page-title-main">VPS29</span> Protein-coding gene in the species Homo sapiens

VPS29 is a human gene coding for the vacuolar protein sorting protein Vps29, a component of the retromer complex.

<span class="mw-page-title-main">SNX3</span> Protein-coding gene in the species Homo sapiens

Sorting nexin-3 is a protein that in humans is encoded by the SNX3 gene.

<span class="mw-page-title-main">SNX27</span> Protein-coding gene in the species Homo sapiens

Sorting nexin family member 27, also known as SNX27, is a human gene.

<span class="mw-page-title-main">GPRASP1</span> Protein-coding gene in humans

G-protein coupled receptor-associated sorting protein 1 is a protein that in humans is encoded by the GPRASP1 gene.

<span class="mw-page-title-main">SNX13</span> Gene of the species Homo sapiens

Sorting nexin-13 is a protein that in humans is encoded by the SNX13 gene.

<span class="mw-page-title-main">SNX15</span> Protein-coding gene in the species Homo sapiens

Sorting nexin-15 is a protein that in humans is encoded by the SNX15 gene.

<span class="mw-page-title-main">SNX4</span> Protein-coding gene in the species Homo sapiens

Sorting nexin-4 is a protein that in humans is encoded by the SNX4 gene.

<span class="mw-page-title-main">SNX21</span> Protein-coding gene in the species Homo sapiens

Sorting nexin-21 is a protein that in humans is encoded by the SNX21 gene.

<span class="mw-page-title-main">SNAG1</span> Protein-coding gene in the species Homo sapiens

Sorting nexin-18 is a protein that in humans is encoded by the SNX18 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000205302 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034484 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Haft CR, de la Luz Sierra M, Barr VA, Haft DH, Taylor SI (Dec 1998). "Identification of a family of sorting nexin molecules and characterization of their association with receptors". Molecular and Cellular Biology. 18 (12): 7278–87. doi:10.1128/mcb.18.12.7278. PMC   109309 . PMID   9819414.
  6. 1 2 "Entrez Gene: SNX2 sorting nexin 2".
  7. Fuchs U, Rehkamp GF, Slany R, Follo M, Borkhardt A (Nov 2003). "The formin-binding protein 17, FBP17, binds via a TNKS binding motif to tankyrase, a protein involved in telomere maintenance". FEBS Letters. 554 (1–2): 10–6. doi:10.1016/S0014-5793(03)01063-9. PMID   14596906. S2CID   19552309.
  8. Fuchs U, Rehkamp G, Haas OA, Slany R, Kōnig M, Bojesen S, Bohle RM, Damm-Welk C, Ludwig WD, Harbott J, Borkhardt A (Jul 2001). "The human formin-binding protein 17 (FBP17) interacts with sorting nexin, SNX2, and is an MLL-fusion partner in acute myelogeneous leukemia". Proceedings of the National Academy of Sciences of the United States of America. 98 (15): 8756–61. Bibcode:2001PNAS...98.8756F. doi: 10.1073/pnas.121433898 . PMC   37508 . PMID   11438682.

Further reading