SNX2

SNX2
Identifiers
Aliases	SNX2 , TRG-9, sorting nexin 2
External IDs	OMIM: 605929; MGI: 1915054; HomoloGene: 2332; GeneCards: SNX2; OMA:SNX2 - orthologs
Gene location (Human) Chr. Chromosome 5 (human) [1] Band 5q23.2 Start 122,775,079 bp [1] End 122,834,543 bp [1]
Gene location (Mouse) Chr. Chromosome 18 (mouse) [2] Band 18|18 D1 Start 53,309,388 bp [2] End 53,353,937 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte Achilles tendon islet of Langerhans ventricular zone gallbladder rectum ganglionic eminence Descending thoracic aorta popliteal artery tibial arteries Top expressed in blastocyst yolk sac spleen sciatic nerve placenta morula morula olfactory epithelium uterus stomach More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein homodimerization activity insulin receptor binding leptin receptor binding epidermal growth factor receptor binding protein binding phosphatidylinositol binding protein heterodimerization activity transferrin receptor binding lipid binding cadherin binding Cellular component cytoplasm cell projection early endosome membrane membrane retromer, tubulation complex retromer complex endosome membrane lamellipodium extrinsic component of membrane cytosol lysosome endosome protein-containing complex Biological process endocytosis vesicle organization early endosome to Golgi transport retrograde transport, endosome to Golgi protein complex oligomerization protein transport intracellular protein transport lamellipodium morphogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6643 67804 Ensembl ENSG00000205302 ENSMUSG00000034484 UniProt O60749 Q9CWK8 RefSeq (mRNA) NM_003100 NM_001278199 NM_026386 NM_001357463 RefSeq (protein) NP_001265128 NP_003091 NP_080662 NP_001344392 Location (UCSC) Chr 5: 122.78 – 122.83 Mb Chr 18: 53.31 – 53.35 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Sorting nexin-2 is a protein that in humans is encoded by the SNX2 gene. ^{[5] [6]}

Function

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associates with formin-binding protein 17, but its function is unknown. This protein may form oligomeric complexes with family members. ^[6]

Interactions

SNX2 has been shown to interact with FNBP1. ^{[7] [8]}

References

1. GRCh38: Ensembl release 89: ENSG00000205302 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000034484 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Haft CR, de la Luz Sierra M, Barr VA, Haft DH, Taylor SI (Dec 1998). "Identification of a family of sorting nexin molecules and characterization of their association with receptors". Molecular and Cellular Biology. 18 (12): 7278–87. doi:10.1128/mcb.18.12.7278. PMC   109309 . PMID   9819414.
6. "Entrez Gene: SNX2 sorting nexin 2".
7. Fuchs U, Rehkamp GF, Slany R, Follo M, Borkhardt A (Nov 2003). "The formin-binding protein 17, FBP17, binds via a TNKS binding motif to tankyrase, a protein involved in telomere maintenance". FEBS Letters. 554 (1–2): 10–6. doi:10.1016/S0014-5793(03)01063-9. PMID   14596906. S2CID   19552309.
8. Fuchs U, Rehkamp G, Haas OA, Slany R, Kōnig M, Bojesen S, Bohle RM, Damm-Welk C, Ludwig WD, Harbott J, Borkhardt A (Jul 2001). "The human formin-binding protein 17 (FBP17) interacts with sorting nexin, SNX2, and is an MLL-fusion partner in acute myelogeneous leukemia". Proceedings of the National Academy of Sciences of the United States of America. 98 (15): 8756–61. Bibcode:2001PNAS...98.8756F. doi: 10.1073/pnas.121433898 . PMC   37508 . PMID   11438682.

Further reading

• Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Haft CR, de la Luz Sierra M, Bafford R, Lesniak MA, Barr VA, Taylor SI (Dec 2000). "Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes". Molecular Biology of the Cell. 11 (12): 4105–16. doi:10.1091/mbc.11.12.4105. PMC   15060 . PMID   11102511.
• Parks WT, Frank DB, Huff C, Renfrew Haft C, Martin J, Meng X, de Caestecker MP, McNally JG, Reddi A, Taylor SI, Roberts AB, Wang T, Lechleider RJ (Jun 2001). "Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases". The Journal of Biological Chemistry. 276 (22): 19332–9. doi: 10.1074/jbc.M100606200 . PMID   11279102.
• Fuchs U, Rehkamp G, Haas OA, Slany R, Kōnig M, Bojesen S, Bohle RM, Damm-Welk C, Ludwig WD, Harbott J, Borkhardt A (Jul 2001). "The human formin-binding protein 17 (FBP17) interacts with sorting nexin, SNX2, and is an MLL-fusion partner in acute myelogeneous leukemia". Proceedings of the National Academy of Sciences of the United States of America. 98 (15): 8756–61. Bibcode:2001PNAS...98.8756F. doi: 10.1073/pnas.121433898 . PMC   37508 . PMID   11438682.
• Teasdale RD, Loci D, Houghton F, Karlsson L, Gleeson PA (Aug 2001). "A large family of endosome-localized proteins related to sorting nexin 1". The Biochemical Journal. 358 (Pt 1): 7–16. doi:10.1042/0264-6021:3580007. PMC   1222026 . PMID   11485546.
• Fuchs U, Rehkamp GF, Slany R, Follo M, Borkhardt A (Nov 2003). "The formin-binding protein 17, FBP17, binds via a TNKS binding motif to tankyrase, a protein involved in telomere maintenance". FEBS Letters. 554 (1–2): 10–6. doi:10.1016/S0014-5793(03)01063-9. PMID   14596906. S2CID   19552309.
• Gullapalli A, Garrett TA, Paing MM, Griffin CT, Yang Y, Trejo J (May 2004). "A role for sorting nexin 2 in epidermal growth factor receptor down-regulation: evidence for distinct functions of sorting nexin 1 and 2 in protein trafficking". Molecular Biology of the Cell. 15 (5): 2143–55. doi:10.1091/mbc.E03-09-0711. PMC   404011 . PMID   14978220.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi: 10.1073/pnas.0404720101 . PMC   514446 . PMID   15302935.
• Schaaf CP, Benzing J, Schmitt T, Erz DH, Tewes M, Bartram CR, Janssen JW (Feb 2005). "Novel interaction partners of the TPR/MET tyrosine kinase". FASEB Journal. 19 (2): 267–9. doi: 10.1096/fj.04-1558fje . PMID   15546961. S2CID   17142907.
• Abdul-Ghani M, Hartman KL, Ngsee JK (Jul 2005). "Abstrakt interacts with and regulates the expression of sorting nexin-2". Journal of Cellular Physiology. 204 (1): 210–8. doi:10.1002/jcp.20285. PMC   2963638 . PMID   15690390.
• Carlton JG, Bujny MV, Peter BJ, Oorschot VM, Rutherford A, Arkell RS, Klumperman J, McMahon HT, Cullen PJ (Oct 2005). "Sorting nexin-2 is associated with tubular elements of the early endosome, but is not essential for retromer-mediated endosome-to-TGN transport". Journal of Cell Science. 118 (Pt 19): 4527–39. doi:10.1242/jcs.02568. PMC   1904489 . PMID   16179610.
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP (Oct 2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nature Biotechnology. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID   16964243. S2CID   14294292.
• Rojas R, Kametaka S, Haft CR, Bonifacino JS (Feb 2007). "Interchangeable but essential functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors". Molecular and Cellular Biology. 27 (3): 1112–24. doi:10.1128/MCB.00156-06. PMC   1800681 . PMID   17101778.
• Skånland SS, Wälchli S, Utskarpen A, Wandinger-Ness A, Sandvig K (Mar 2007). "Phosphoinositide-regulated retrograde transport of ricin: crosstalk between hVps34 and sorting nexins". Traffic. 8 (3): 297–309. doi:10.1111/j.1600-0854.2006.00527.x. hdl: 10852/11339 . PMID   17319803. S2CID   21600584.