SNX17

SNX17
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3FOG, 3LUI, 4GXB, 4TKN
Identifiers
Aliases	SNX17 , sorting nexin 17
External IDs	OMIM: 605963 MGI: 2387801 HomoloGene: 8838 GeneCards: SNX17
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2p23.3 Start 27,370,496 bp [1] End 27,377,535 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5|5 B1 Start 31,350,571 bp [2] End 31,356,487 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Right adrenal gland monocyte Left adrenal gland anterior pituitary stromal cell of endometrium right coronary artery spleen right lobe of thyroid gland left uterine tube thoracic aorta Top expressed in medial ganglionic eminence renal corpuscle internal carotid artery external carotid artery Paneth cell endocardial cushion median eminence lacrimal gland vas deferens arcuate nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function low-density lipoprotein particle receptor binding protein C-terminus binding protein binding phosphatidylinositol binding signaling receptor binding lipid binding Cellular component cytosol endosome Golgi apparatus membrane intracellular membrane-bounded organelle early endosome endosome membrane cytoplasmic vesicle membrane cytoplasm cytoplasmic vesicle protein-containing complex Biological process regulation of endocytosis cardiac septum development cholesterol catabolic process receptor-mediated endocytosis coronary vasculature development endosomal transport aorta development protein transport signal transduction intracellular protein transport endocytic recycling Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9784 266781 Ensembl ENSG00000115234 ENSMUSG00000029146 UniProt Q15036 Q8BVL3 RefSeq (mRNA) NM_001267059 NM_001267060 NM_001267061 NM_014748 NM_153680 RefSeq (protein) NP_001253988 NP_001253989 NP_001253990 NP_055563 NP_710147 Location (UCSC) Chr 2: 27.37 – 27.38 Mb Chr 5: 31.35 – 31.36 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Sorting nexin-17 is a protein that in humans is encoded by the SNX17 gene. ^{[5] [6] [7]}

Function

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but contains a B41 domain. This protein interacts with the cytoplasmic domain of P-selectin, and may function in the intracellular trafficking of P-selectin. ^[7]

Interactions

SNX17 has been shown to interact with Low density lipoprotein receptor-related protein 8 ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000115234 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029146 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Stockinger W, Sailler B, Strasser V, Recheis B, Fasching D, Kahr L, Schneider WJ, Nimpf J (Aug 2002). "The PX-domain protein SNX17 interacts with members of the LDL receptor family and modulates endocytosis of the LDL receptor". EMBO J. 21 (16): 4259–67. doi:10.1093/emboj/cdf435. PMC   126172 . PMID   12169628.
6. Knauth P, Schlüter T, Czubayko M, Kirsch C, Florian V, Schreckenberger S, Hahn H, Bohnensack R (Mar 2005). "Functions of sorting nexin 17 domains and recognition motif for P-selectin trafficking". J. Mol. Biol. 347 (4): 813–25. doi:10.1016/j.jmb.2005.02.004. PMID   15769472.
7. "Entrez Gene: SNX17 sorting nexin 17".

Further reading

• Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S (1994). "Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 1 (5): 223–9. doi: 10.1093/dnares/1.5.223 . PMID   7584044.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Hoja MR, Wahlestedt C, Höög C (2000). "A visual intracellular classification strategy for uncharacterized human proteins". Exp. Cell Res. 259 (1): 239–46. doi:10.1006/excr.2000.4948. PMID   10942595.
• Florian V, Schlüter T, Bohnensack R (2001). "A new member of the sorting nexin family interacts with the C-terminus of P-selectin". Biochem. Biophys. Res. Commun. 281 (4): 1045–50. doi:10.1006/bbrc.2001.4467. PMID   11237770.
• Teasdale RD, Loci D, Houghton F, Karlsson L, Gleeson PA (2001). "A large family of endosome-localized proteins related to sorting nexin 1". Biochem. J. 358 (Pt 1): 7–16. doi:10.1042/0264-6021:3580007. PMC   1222026 . PMID   11485546.
• Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J (2003). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID   12665801. S2CID   23783563.
• Burden JJ, Sun XM, García AB, Soutar AK (2004). "Sorting motifs in the intracellular domain of the low density lipoprotein receptor interact with a novel domain of sorting nexin-17". J. Biol. Chem. 279 (16): 16237–45. doi: 10.1074/jbc.M313689200 . PMID   14739284.
• Williams R, Schlüter T, Roberts MS, Knauth P, Bohnensack R, Cutler DF (2004). "Sorting nexin 17 accelerates internalization yet retards degradation of P-selectin". Mol. Biol. Cell. 15 (7): 3095–105. doi:10.1091/mbc.E04-02-0143. PMC   452567 . PMID   15121882.
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC   442148 . PMID   15231748.
• van Kerkhof P, Lee J, McCormick L, Tetrault E, Lu W, Schoenfish M, Oorschot V, Strous GJ, Klumperman J, Bu G (2005). "Sorting nexin 17 facilitates LRP recycling in the early endosome". EMBO J. 24 (16): 2851–61. doi:10.1038/sj.emboj.7600756. PMC   1187941 . PMID   16052210.
• Czubayko M, Knauth P, Schlüter T, Florian V, Bohnensack R (2006). "Sorting nexin 17, a non-self-assembling and a PtdIns(3)P high class affinity protein, interacts with the cerebral cavernous malformation related protein KRIT1". Biochem. Biophys. Res. Commun. 345 (3): 1264–72. doi:10.1016/j.bbrc.2006.04.129. PMID   16712798.