SNX17

Last updated
SNX17
Protein SNX17 PDB 3FOG.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases SNX17 , sorting nexin 17
External IDs OMIM: 605963; MGI: 2387801; HomoloGene: 8838; GeneCards: SNX17; OMA:SNX17 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001267059
NM_001267060
NM_001267061
NM_014748

NM_153680

RefSeq (protein)

NP_001253988
NP_001253989
NP_001253990
NP_055563

NP_710147

Location (UCSC) Chr 2: 27.37 – 27.38 Mb Chr 5: 31.35 – 31.36 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Sorting nexin-17 is a protein that in humans is encoded by the SNX17 gene. [5] [6] [7]

Contents

Function

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but contains a B41 domain. This protein interacts with the cytoplasmic domain of P-selectin, and may function in the intracellular trafficking of P-selectin. [7]

Interactions

SNX17 has been shown to interact with Low density lipoprotein receptor-related protein 8 [5]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000115234 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029146 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 Stockinger W, Sailler B, Strasser V, Recheis B, Fasching D, Kahr L, Schneider WJ, Nimpf J (Aug 2002). "The PX-domain protein SNX17 interacts with members of the LDL receptor family and modulates endocytosis of the LDL receptor". EMBO J. 21 (16): 4259–67. doi:10.1093/emboj/cdf435. PMC   126172 . PMID   12169628.
  6. Knauth P, Schlüter T, Czubayko M, Kirsch C, Florian V, Schreckenberger S, Hahn H, Bohnensack R (Mar 2005). "Functions of sorting nexin 17 domains and recognition motif for P-selectin trafficking". J. Mol. Biol. 347 (4): 813–25. doi:10.1016/j.jmb.2005.02.004. PMID   15769472.
  7. 1 2 "Entrez Gene: SNX17 sorting nexin 17".

Further reading