SNAG1

SNX18
Identifiers
Aliases	SNX18 , SH3PX2, SH3PXD3B, SNAG1, sorting nexin 18
External IDs	MGI: 2137642 HomoloGene: 14164 GeneCards: SNX18
Gene location (Human) Chr. Chromosome 5 (human) [1] Band 5q11.2 Start 54,517,759 bp [1] End 54,546,586 bp [1]
Gene location (Mouse) Chr. Chromosome 13 (mouse) [2] Band 13|13 D2.2 Start 113,592,179 bp [2] End 113,618,564 bp [2]
Gene ontology Molecular function • GO:0001948 protein binding • phosphatidylinositol binding • phosphatidylinositol-4,5-bisphosphate binding • lipid binding Cellular component • membrane • extrinsic component of cytoplasmic side of plasma membrane • cell membrane • endosome membrane • extracellular exosome • cytoplasmic vesicle membrane • endomembrane system • clathrin-coated vesicle • cytoplasmic vesicle • endosome Biological process • cleavage furrow formation • cell division • endosomal transport • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity • protein transport • cell cycle • endocytosis • mitotic cytokinesis • GO:0007067 mitotic cell cycle • transport Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	112574	170625
Ensembl	ENSG00000178996	ENSMUSG00000042364
UniProt	Q96RF0	Q91ZR2 Q8C788
RefSeq (mRNA)	NM_052870 NM_001102575 NM_001145427	NM_130796
RefSeq (protein)	NP_001096045 NP_001138899 NP_443102	NP_570614
Location (UCSC)	Chr 5: 54.52 – 54.55 Mb	Chr 13: 113.59 – 113.62 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Sorting nexin-18 is a protein that in humans is encoded by the SNX18 gene. ^{[5] [6] [7]}

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but contains a SH3 domain. The specific function of this protein has not been determined. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000178996 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000042364 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Seet LF, Hong W (Sep 2006). "The Phox (PX) domain proteins and membrane traffic". Biochim Biophys Acta. 1761 (8): 878–96. doi:10.1016/j.bbalip.2006.04.011. PMID   16782399.
6. Thornhill PB, Cohn JB, Drury G, Stanford WL, Bernstein A, Desbarats J (Sep 2007). "A proteomic screen reveals novel Fas ligand interacting proteins within nervous system Schwann cells". FEBS Lett. 581 (23): 4455–62. doi:10.1016/j.febslet.2007.08.025. PMID   17761170. S2CID   23223511.
7. "Entrez Gene: SNAG1 sorting nexin associated golgi protein 1".

Further reading

• Worby CA, Dixon JE (2003). "Sorting out the cellular functions of sorting nexins". Nat. Rev. Mol. Cell Biol. 3 (12): 919–31. doi:10.1038/nrm974. PMID   12461558. S2CID   36361630.
• Xu Y, Seet LF, Hanson B, Hong W (2002). "The Phox homology (PX) domain, a new player in phosphoinositide signalling". Biochem. J. 360 (Pt 3): 513–30. doi:10.1042/0264-6021:3600513. PMC   1222253 . PMID   11736640.
• Ozyildirim AM, Wistow GJ, Gao J, et al. (2005). "The lacrimal gland transcriptome is an unusually rich source of rare and poorly characterized gene transcripts". Invest. Ophthalmol. Vis. Sci. 46 (5): 1572–80. CiteSeerX   10.1.1.123.3574 . doi:10.1167/iovs.04-1380. PMID   15851553.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Schulze WX, Mann M (2004). "A novel proteomic screen for peptide-protein interactions". J. Biol. Chem. 279 (11): 10756–64. doi: 10.1074/jbc.M309909200 . PMID   14679214.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC   139241 . PMID   12477932.
• Teasdale RD, Loci D, Houghton F, et al. (2001). "A large family of endosome-localized proteins related to sorting nexin 1". Biochem. J. 358 (Pt 1): 7–16. doi:10.1042/0264-6021:3580007. PMC   1222026 . PMID   11485546.