SNX13

SNX13
Identifiers
Aliases	SNX13 , RGS-PX1, sorting nexin 13
External IDs	OMIM: 606589 MGI: 2661416 HomoloGene: 41011 GeneCards: SNX13
Gene location (Mouse) Chr. Chromosome 12 (mouse) [1] Band 12|12 A3 Start 35,047,186 bp [1] End 35,147,479 bp [1]
RNA expression pattern More reference expression data
Gene ontology Molecular function • phosphatidylinositol binding • phosphatidylinositol-3-phosphate binding • lipid binding Cellular component • endosome • early endosome • early endosome membrane • membrane Biological process • protein transport • negative regulation of signal transduction • intracellular protein transport • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	23161	217463
Ensembl	ENSG00000071189	ENSMUSG00000020590
UniProt	Q9Y5W8	Q6PHS6
RefSeq (mRNA)	NM_015132	NM_001014973
RefSeq (protein)	NP_055947 NP_001337791 NP_001337792 NP_001337793 NP_001337795 NP_001337796 NP_001337797 NP_001337799	NP_001014973
Location (UCSC)	n/a	Chr 12: 35.05 – 35.15 Mb
PubMed search	[2]	[3]
Wikidata
View/Edit Human View/Edit Mouse

Sorting nexin-13 is a protein that in humans is encoded by the SNX13 gene. ^{[4] [5] [6]}

Function

This gene encodes a PHOX domain- and RGS domain-containing protein that belongs to the sorting nexin (SNX) family and the regulator of G protein signaling (RGS) family. The PHOX domain is a phosphoinositide binding domain, and the SNX family members are involved in intracellular trafficking. The RGS family members are regulatory molecules that act as GTPase activating proteins for G alpha subunits of heterotrimeric G proteins. The RGS domain of this protein interacts with G alpha(s), accelerates its GTP hydrolysis, and attenuates G alpha(s)-mediated signaling. Overexpression of this protein delays lysosomal degradation of the epidermal growth factor receptor. Because of its bifunctional role, this protein may link heterotrimeric G protein signaling and vesicular trafficking. ^[6]

References

1. GRCm38: Ensembl release 89: ENSMUSG00000020590 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Teasdale RD, Loci D, Houghton F, Karlsson L, Gleeson PA (August 2001). "A large family of endosome-localized proteins related to sorting nexin 1". The Biochemical Journal. 358 (Pt 1): 7–16. doi:10.1042/0264-6021:3580007. PMC   1222026 . PMID   11485546.
5. Zheng B, Ma YC, Ostrom RS, Lavoie C, Gill GN, Insel PA, Huang XY, Farquhar MG (November 2001). "RGS-PX1, a GAP for GalphaS and sorting nexin in vesicular trafficking". Science. 294 (5548): 1939–42. Bibcode:2001Sci...294.1939Z. doi:10.1126/science.1064757. PMID   11729322. S2CID   85169394.
6. "Entrez Gene: SNX13 sorting nexin 13".

Further reading

• Worby CA, Dixon JE (December 2002). "Sorting out the cellular functions of sorting nexins". Nature Reviews. Molecular Cell Biology. 3 (12): 919–31. doi:10.1038/nrm974. PMID   12461558. S2CID   36361630.
• Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (October 1998). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (5): 277–86. doi: 10.1093/dnares/5.5.277 . PMID   9872452.
• Kosan C, Kunz J (2003). "Identification and characterisation of the gene TWIST NEIGHBOR (TWISTNB) located in the microdeletion syndrome 7p21 region". Cytogenetic and Genome Research. 97 (3–4): 167–70. doi:10.1159/000066618. PMID   12438708. S2CID   27223779.
• Hillman RT, Green RE, Brenner SE (2005). "An unappreciated role for RNA surveillance". Genome Biology. 5 (2): R8. doi:10.1186/gb-2004-5-2-r8. PMC   395752 . PMID   14759258.