SNX21

SNX21
Identifiers
Aliases	SNX21 , C20orf161, PP3993, SNX-L, dJ337O18.4, sorting nexin family member 21, SNXL
External IDs	MGI: 1917729 HomoloGene: 43132 GeneCards: SNX21
Gene location (Human)
Chr.	Chromosome 20 (human)
End	45,843,276 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	164,635,736 bp
RNA expression pattern
	Top expressed in
	skin of abdomen; ; right coronary artery; ; endothelial cell; ; gastric mucosa; ; left uterine tube; ; canal of the cervix; ; left coronary artery; ; popliteal artery; ; ascending aorta; ; subcutaneous adipose tissue;
	Top expressed in
	lip; ; superior frontal gyrus; ; facial motor nucleus; ; cerebellar cortex; ; ascending aorta; ; Ankle joint; ; triceps brachii muscle; ; sternocleidomastoid muscle; ; skeletal muscle tissue; ; proximal tubule;
	More reference expression data
	n/a
Gene ontology
Molecular function	lipid binding ; phosphatidylinositol binding ; phosphatidylinositol-4,5-bisphosphate binding ; phosphatidylinositol-3-phosphate binding ;
Cellular component	membrane ; cytoplasmic vesicle ; cytoplasmic vesicle membrane ; endosome ; early endosome membrane ;
Biological process	protein transport ;
	Sources:Amigo / QuickGO
Orthologs
	90203
	101113
	ENSG00000124104
	ENSMUSG00000050373
	Q969T3
	Q3UR97
	NM_001042632 ; NM_001042633 ; NM_033421 ; NM_152897
	NM_133924 ; NM_001399716
	NP_001036097 ; NP_001036098 ; NP_219489 ; NP_690857
	NP_598685 ; NP_001386645
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated October 18, 2022

Sorting nexin-21 is a protein that in humans is encoded by the SNX21 gene.^[5]^[6]^[7]

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members. The specific function of this protein has not been determined. Multiple transcript variants encoding distinct isoforms have been identified for this gene.^[7]

Related Research Articles

<span class="mw-page-title-main">PX domain</span>

The PX domain is a phosphoinositide-binding structural domain involved in targeting of proteins to cell membranes.

Sorting nexin-1 is a protein that in humans is encoded by the SNX1 gene. The protein encoded by this gene is a sorting nexin. SNX1 is a component of the retromer complex.

Disintegrin and metalloproteinase domain-containing protein 9 is an enzyme that in humans is encoded by the ADAM9 gene.

Sorting nexin-9 is a protein that in humans is encoded by the SNX9 gene.

Sorting nexin-2 is a protein that in humans is encoded by the SNX2 gene.

Sorting nexin-17 is a protein that in humans is encoded by the SNX17 gene.

Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide is a protein that in humans is encoded by the DAPP1 gene.

Phosphatidylinositol 3-kinase regulatory subunit gamma is an enzyme, which in humans is encoded by the PIK3R3 gene.

Sorting nexin-5 is a protein that in humans is encoded by the SNX5 gene.

TC10/CDC42 GTPase-activating protein is an enzyme that in humans is encoded by the SNX26 gene.

Sorting nexin-3 is a protein that in humans is encoded by the SNX3 gene.

Pleckstrin homology domain-containing family B member 2 is a protein that in humans is encoded by the PLEKHB2 gene.

Sorting nexin family member 27, also known as SNX27, is a human gene.

Sorting nexin-13 is a protein that in humans is encoded by the SNX13 gene.

Sorting nexin-15 is a protein that in humans is encoded by the SNX15 gene.

Kinesin family member 16B, also known as KIF16B, is a protein which in humans is encoded by the KIF16B gene.

Sorting nexin-4 is a protein that in humans is encoded by the SNX4 gene.

Sorting nexin-18 is a protein that in humans is encoded by the SNX18 gene.

Sorting nexins are a large group of proteins that are localized in the cytoplasm and have the potential for membrane association either through their lipid-binding PX domain or through protein–protein interactions with membrane-associated protein complexes Some members of this family have been shown to facilitate protein sorting.

Sorting nexin 10 is a protein that in humans is encoded by the SNX10 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000124104 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000050373 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Worby CA, Dixon JE (Dec 2002). "Sorting out the cellular functions of sorting nexins". Nat Rev Mol Cell Biol. 3 (12): 919–31. doi:10.1038/nrm974. PMID 12461558. S2CID 36361630.
↑ Zeng W, Yuan W, Wang Y, Jiao W, Zhu Y, Huang C, Li D, Li Y, Zhu C, Wu X, Liu M (Dec 2002). "Expression of a novel member of sorting nexin gene family, SNX-L, in human liver development". Biochem Biophys Res Commun. 299 (4): 542–8. doi:10.1016/S0006-291X(02)02695-5. PMID 12459172.
1 2 "Entrez Gene: SNX21 sorting nexin family member 21".

Xu Y, Seet LF, Hanson B, Hong W (2002). "The Phox homology (PX) domain, a new player in phosphoinositide signalling". Biochem. J. 360 (Pt 3): 513–30. doi:10.1042/0264-6021:3600513. PMC 1222253 . PMID 11736640.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129 . PMID 16344560.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi: 10.1038/414865a . PMID 11780052.
Teasdale RD, Loci D, Houghton F, et al. (2001). "A large family of endosome-localized proteins related to sorting nexin 1". Biochem. J. 358 (Pt 1): 7–16. doi:10.1042/0264-6021:3580007. PMC 1222026 . PMID 11485546.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000124104 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000050373 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12461558-5] Worby CA, Dixon JE (Dec 2002). "Sorting out the cellular functions of sorting nexins". Nat Rev Mol Cell Biol. 3 (12): 919–31. doi:10.1038/nrm974. PMID 12461558. S2CID 36361630.

[pmid12459172-6] Zeng W, Yuan W, Wang Y, Jiao W, Zhu Y, Huang C, Li D, Li Y, Zhu C, Wu X, Liu M (Dec 2002). "Expression of a novel member of sorting nexin gene family, SNX-L, in human liver development". Biochem Biophys Res Commun. 299 (4): 542–8. doi:10.1016/S0006-291X(02)02695-5. PMID 12459172.

[entrez-7] 1 2 "Entrez Gene: SNX21 sorting nexin family member 21".

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v t e Sorting nexins
SNX-BAR	SNX1 SNX2 SNX4 SNX5 SNX6 SNX7 SNX8 SNX9 SNX18 SNX30 SNX32 SNX33
SNX-PX	SNX3 SNX10 SNX11 SNX12 SNX16 SNX20 SNX21 SNX22 SNX24 SNX29
SNX-Other	SNX13 SNX14 SNX15 SNX17 SNX19 SNX23 SNX25 SNX26 SNX27 SNX28 SNX31
Related articles	PX domain BAR domain Retromer

SNX21

Related Research Articles

References

Further reading