SNX26

ARHGAP33
Identifiers
Aliases	ARHGAP33 , NOMA-GAP, SNX26, TCGAP, Rho GTPase activating protein 33
External IDs	OMIM: 614902 MGI: 2673998 HomoloGene: 76448 GeneCards: ARHGAP33
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19q13.12 Start 35,774,532 bp [1] End 35,788,822 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 B1 Start 30,522,226 bp [2] End 30,535,060 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence right uterine tube anterior pituitary nucleus accumbens amygdala Brodmann area 9 caudate nucleus cingulate gyrus canal of the cervix tibial nerve Top expressed in superior frontal gyrus olfactory tubercle piriform cortex visual cortex subiculum nucleus accumbens ganglionic eminence prefrontal cortex globus pallidus suprachiasmatic nucleus More reference expression data BioGPS n/a
Gene ontology Molecular function phosphatidylinositol binding protein binding GTPase activator activity protein kinase binding Cellular component cytosol cytoplasm plasma membrane cell cortex actin cytoskeleton protein-containing complex dendritic spine Biological process regulation of small GTPase mediated signal transduction protein transport positive regulation of GTPase activity signal transduction small GTPase mediated signal transduction response to toxic substance regulation of dendritic spine morphogenesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 115703 233071 Ensembl ENSG00000004777 ENSMUSG00000036882 UniProt O14559 Q80YF9 RefSeq (mRNA) NM_001172630 NM_052948 NM_001366178 NM_001289670 NM_001289682 NM_178252 RefSeq (protein) NP_001166101 NP_443180 NP_001353107 NP_001276599 NP_001276611 NP_839983 Location (UCSC) Chr 19: 35.77 – 35.79 Mb Chr 7: 30.52 – 30.54 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

TC10/CDC42 GTPase-activating protein is an enzyme that in humans is encoded by the SNX26 gene. ^{[5] [6] [7]}

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. The specific function of this protein has not been elucidated. Alternative splice variants have been described but their full length nature has not been determined. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000004777 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000036882 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Peck J, Douglas G IV, Wu CH, Burbelo PD (Sep 2002). "Human RhoGAP domain-containing proteins: structure, function and evolutionary relationships". FEBS Lett. 528 (1–3): 27–34. doi:10.1016/S0014-5793(02)03331-8. PMID   12297274. S2CID   30443852.
6. Worby CA, Dixon JE (Dec 2002). "Sorting out the cellular functions of sorting nexins". Nat Rev Mol Cell Biol. 3 (12): 919–31. doi:10.1038/nrm974. PMID   12461558. S2CID   36361630.
7. "Entrez Gene: SNX26 sorting nexin 26".

Further reading

• Xu Y, Seet LF, Hanson B, Hong W (2002). "The Phox homology (PX) domain, a new player in phosphoinositide signalling". Biochem. J. 360 (Pt 3): 513–30. doi:10.1042/0264-6021:3600513. PMC   1222253 . PMID   11736640.
• Dehal P, Predki P, Olsen AS, et al. (2001). "Human chromosome 19 and related regions in mouse: conservative and lineage-specific evolution". Science. 293 (5527): 104–11. doi:10.1126/science.1060310. PMID   11441184. S2CID   826987.
• Teasdale RD, Loci D, Houghton F, et al. (2001). "A large family of endosome-localized proteins related to sorting nexin 1". Biochem. J. 358 (Pt 1): 7–16. doi:10.1042/0264-6021:3580007. PMC   1222026 . PMID   11485546.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Chiang SH, Hwang J, Legendre M, et al. (2003). "TCGAP, a multidomain Rho GTPase-activating protein involved in insulin-stimulated glucose transport". EMBO J. 22 (11): 2679–91. doi:10.1093/emboj/cdg262. PMC   156759 . PMID   12773384.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. Bibcode:2004Natur.428..529G. doi: 10.1038/nature02399 . PMID   15057824.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Liu H, Nakazawa T, Tezuka T, Yamamoto T (2006). "Physical and functional interaction of Fyn tyrosine kinase with a brain-enriched Rho GTPase-activating protein TCGAP". J. Biol. Chem. 281 (33): 23611–9. doi: 10.1074/jbc.M511205200 . PMID   16777849.