SNX9

SNX9
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2RAI, 2RAJ, 2RAK, 3DYT, 3DYU, 3LGE
Identifiers
Aliases	SNX9 , SDP1, SH3PX1, SH3PXD3A, WISP, sorting nexin 9
External IDs	OMIM: 605952; MGI: 1913866; HomoloGene: 49454; GeneCards: SNX9; OMA:SNX9 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) [1] Band 6q25.3 Start 157,700,387 bp [1] End 157,945,077 bp [1]
Gene location (Mouse) Chr. Chromosome 17 (mouse) [2] Band 17 A1|17 3.51 cM Start 5,891,604 bp [2] End 5,982,229 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in cartilage tissue mucosa of ileum superficial temporal artery Achilles tendon decidua right coronary artery tendon of biceps brachii tail of epididymis synovial membrane tibial arteries Top expressed in Ileal epithelium zygote secondary oocyte primary oocyte choroid plexus of fourth ventricle jejunum lactiferous gland duodenum right kidney calvaria More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein homodimerization activity Arp2/3 complex binding 1-phosphatidylinositol binding protein binding phosphatidylinositol binding ubiquitin protein ligase binding lipid binding cadherin binding identical protein binding Cellular component cytoplasm Golgi apparatus cell projection membrane ruffle extrinsic component of cytoplasmic side of plasma membrane plasma membrane trans-Golgi network extracellular exosome cytoplasmic vesicle membrane clathrin-coated vesicle cytosol cytoplasmic vesicle cuticular plate Biological process endocytosis cleavage furrow formation mitotic cytokinesis positive regulation of membrane protein ectodomain proteolysis receptor-mediated endocytosis plasma membrane tubulation cell division endosomal transport positive regulation of GTPase activity positive regulation of protein oligomerization protein transport lipid tube assembly cell cycle intracellular protein transport positive regulation of protein kinase activity membrane organization mitotic cell cycle transport positive regulation of actin filament polymerization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51429 66616 Ensembl ENSG00000130340 ENSMUSG00000002365 UniProt Q9Y5X1 Q91VH2 RefSeq (mRNA) NM_016224 NM_025664 RefSeq (protein) NP_057308 NP_079940 Location (UCSC) Chr 6: 157.7 – 157.95 Mb Chr 17: 5.89 – 5.98 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Sorting nexin-9 is a protein that in humans is encoded by the SNX9 gene. ^{[5] [6] [7]}

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but does contain an SH3 domain near its N-terminus. This protein interacts with the cytoplasmic domains of the precursor but not the processed forms of a disintegrin and metalloprotease domain 9 and 15. This protein binds the beta-appendage domain of adaptor protein 2 and may function to assist adaptor protein 2 in its role at the plasma membrane. This protein interacts with activated Cdc42-associated kinase-2 to regulate the degradation of epidermal growth factor receptor protein. ^[7]

Interactions

SNX9 has been shown to interact with ADAM9, ^[5] DNM2 ^[8] and ADAM15. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000130340 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000002365 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Howard L; Nelson KK; Maciewicz RA; Blobel CP (Dec 1999). "Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1". J Biol Chem. 274 (44): 31693–9. doi: 10.1074/jbc.274.44.31693 . PMID   10531379.
6. Yarar D; Waterman-Storer CM; Schmid SL (Jul 2007). "SNX9 couples actin assembly to phosphoinositide signals and is required for membrane remodeling during endocytosis". Dev Cell. 13 (1): 43–56. doi: 10.1016/j.devcel.2007.04.014 . PMID   17609109.
7. "Entrez Gene: SNX9 sorting nexin 9".
8. Lundmark, Richard; Carlsson Sven R (Nov 2003). "Sorting nexin 9 participates in clathrin-mediated endocytosis through interactions with the core components". J. Biol. Chem. 278 (47). United States: 46772–81. doi: 10.1074/jbc.M307334200 . ISSN   0021-9258. PMID   12952949.

Further reading

• Teasdale RD, Loci D, Houghton F, et al. (2001). "A large family of endosome-localized proteins related to sorting nexin 1". Biochem. J. 358 (Pt 1): 7–16. doi:10.1042/0264-6021:3580007. PMC   1222026 . PMID   11485546.
• Lin Q; Lo CG; Cerione RA; Yang W (2002). "The Cdc42 target ACK2 interacts with sorting nexin 9 (SH3PX1) to regulate epidermal growth factor receptor degradation". J. Biol. Chem. 277 (12): 10134–8. doi: 10.1074/jbc.M110329200 . PMID   11799118.
• Lundmark R; Carlsson SR (2002). "The beta-appendages of the four adaptor-protein (AP) complexes: structure and binding properties, and identification of sorting nexin 9 as an accessory protein to AP-2". Biochem. J. 362 (Pt 3): 597–607. doi:10.1042/0264-6021:3620597. PMC   1222423 . PMID   11879186.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Lundmark R; Carlsson SR (2004). "Sorting nexin 9 participates in clathrin-mediated endocytosis through interactions with the core components". J. Biol. Chem. 278 (47): 46772–81. doi: 10.1074/jbc.M307334200 . PMID   12952949.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi: 10.1038/nature02055 . PMID   14574404.
• Schulze WX; Mann M (2004). "A novel proteomic screen for peptide-protein interactions". J. Biol. Chem. 279 (11): 10756–64. doi: 10.1074/jbc.M309909200 . PMID   14679214.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Lehner B; Sanderson CM (2004). "A protein interaction framework for human mRNA degradation". Genome Res. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC   442147 . PMID   15231747.
• Lundmark R; Carlsson SR (2004). "Regulated membrane recruitment of dynamin-2 mediated by sorting nexin 9". J. Biol. Chem. 279 (41): 42694–702. doi: 10.1074/jbc.M407430200 . PMID   15299020.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Soulet F; Yarar D; Leonard M; Schmid SL (2005). "SNX9 regulates dynamin assembly and is required for efficient clathrin-mediated endocytosis". Mol. Biol. Cell. 16 (4): 2058–67. doi:10.1091/mbc.E04-11-1016. PMC   1073683 . PMID   15703209.
• Yeow-Fong L; Lim L; Manser E (2005). "SNX9 as an adaptor for linking synaptojanin-1 to the Cdc42 effector ACK1". FEBS Lett. 579 (22): 5040–8. doi: 10.1016/j.febslet.2005.07.093 . PMID   16137687. S2CID   44482842.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Childress C; Lin Q; Yang W (2006). "Dimerization is required for SH3PX1 tyrosine phosphorylation in response to epidermal growth factor signalling and interaction with ACK2". Biochem. J. 394 (Pt 3): 693–8. doi:10.1042/BJ20050576. PMC   1383719 . PMID   16316319.
• Marchès O, Batchelor M, Shaw RK, et al. (2006). "EspF of enteropathogenic Escherichia coli binds sorting nexin 9". J. Bacteriol. 188 (8): 3110–5. doi:10.1128/JB.188.8.3110-3115.2006. PMC   1447016 . PMID   16585770.
• Schmid EM, Ford MG, Burtey A, et al. (2007). "Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly". PLOS Biol. 4 (9): e262. doi: 10.1371/journal.pbio.0040262 . PMC   1540706 . PMID   16903783.
• Badour K, McGavin MK, Zhang J, et al. (2007). "Interaction of the Wiskott-Aldrich syndrome protein with sorting nexin 9 is required for CD28 endocytosis and cosignaling in T cells". Proc. Natl. Acad. Sci. U.S.A. 104 (5): 1593–8. Bibcode:2007PNAS..104.1593B. doi: 10.1073/pnas.0610543104 . PMC   1785243 . PMID   17242350.