SNX9

Last updated
SNX9
Protein SNX9 PDB 2RAI.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases SNX9 , SDP1, SH3PX1, SH3PXD3A, WISP, sorting nexin 9
External IDs OMIM: 605952 MGI: 1913866 HomoloGene: 49454 GeneCards: SNX9
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_016224

NM_025664

RefSeq (protein)

NP_057308

NP_079940

Location (UCSC) Chr 6: 157.7 – 157.95 Mb Chr 17: 5.89 – 5.98 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Sorting nexin-9 is a protein that in humans is encoded by the SNX9 gene. [5] [6] [7]

Contents

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but does contain an SH3 domain near its N-terminus. This protein interacts with the cytoplasmic domains of the precursor but not the processed forms of a disintegrin and metalloprotease domain 9 and 15. This protein binds the beta-appendage domain of adaptor protein 2 and may function to assist adaptor protein 2 in its role at the plasma membrane. This protein interacts with activated Cdc42-associated kinase-2 to regulate the degradation of epidermal growth factor receptor protein. [7]

Interactions

SNX9 has been shown to interact with ADAM9, [5] DNM2 [8] and ADAM15. [5]

Related Research Articles

<span class="mw-page-title-main">SNX1</span> Protein-coding gene in the species Homo sapiens

Sorting nexin-1 is a protein that in humans is encoded by the SNX1 gene. The protein encoded by this gene is a sorting nexin. SNX1 is a component of the retromer complex.

<span class="mw-page-title-main">BIN1</span> Protein-coding gene in Homo sapiens

Myc box-dependent-interacting protein 1, also known as Bridging Integrator-1 and Amphiphysin-2 is a protein that in humans is encoded by the BIN1 gene.

<span class="mw-page-title-main">EPS15</span> Protein-coding gene in the species Homo sapiens

Epidermal growth factor receptor substrate 15 is a protein that in humans is encoded by the EPS15 gene.

<span class="mw-page-title-main">DNM2</span> Protein-coding gene in the species Homo sapiens

Dynamin-2 is a protein that in humans is encoded by the DNM2 gene.

<span class="mw-page-title-main">Adaptor-related protein complex 2, alpha 1</span> Protein-coding gene in the species Homo sapiens

AP-2 complex subunit alpha-1 is a protein that in humans is encoded by the AP2A1 gene.

<span class="mw-page-title-main">CLTC</span> Protein-coding gene in the species Homo sapiens

Clathrin heavy chain 1 is a protein that in humans is encoded by the CLTC gene.

<span class="mw-page-title-main">DNM1</span> Protein-coding gene in the species Homo sapiens

Dynamin-1 is a protein that in humans is encoded by the DNM1 gene.

<span class="mw-page-title-main">AP1B1</span> Protein-coding gene in the species Homo sapiens

AP-1 complex subunit beta-1 is a protein that in humans is encoded by the AP1B1 gene.

<span class="mw-page-title-main">SH3GL2</span> Protein-coding gene in the species Homo sapiens

Endophilin-A1 is a protein that in humans is encoded by the SH3GL2 gene.

<span class="mw-page-title-main">FNBP1</span> Protein-coding gene in the species Homo sapiens

Formin-binding protein 1 is a protein that in humans is encoded by the FNBP1 gene.

<span class="mw-page-title-main">Low-density lipoprotein receptor adapter protein 1</span> Protein-coding gene in the species Homo sapiens

Low-density lipoprotein receptor adapter protein 1 is a protein that in humans is encoded by the LDLRAP1 gene.

<span class="mw-page-title-main">AP1G2</span> Protein-coding gene in the species Homo sapiens

AP-1 complex subunit gamma-like 2 is a protein that in humans is encoded by the AP1G2 gene.

<span class="mw-page-title-main">SNX17</span> Protein-coding gene in the species Homo sapiens

Sorting nexin-17 is a protein that in humans is encoded by the SNX17 gene.

<span class="mw-page-title-main">EPN1</span> Protein-coding gene in the species Homo sapiens

Epsin-1 is a protein that in humans is encoded by the EPN1 gene.

<span class="mw-page-title-main">SNX26</span> Protein-coding gene in the species Homo sapiens

TC10/CDC42 GTPase-activating protein is an enzyme that in humans is encoded by the SNX26 gene.

<span class="mw-page-title-main">SNX3</span> Protein-coding gene in the species Homo sapiens

Sorting nexin-3 is a protein that in humans is encoded by the SNX3 gene.

<span class="mw-page-title-main">SNX15</span> Protein-coding gene in the species Homo sapiens

Sorting nexin-15 is a protein that in humans is encoded by the SNX15 gene.

<span class="mw-page-title-main">SNX4</span> Protein-coding gene in the species Homo sapiens

Sorting nexin-4 is a protein that in humans is encoded by the SNX4 gene.

<span class="mw-page-title-main">SNAG1</span> Protein-coding gene in the species Homo sapiens

Sorting nexin-18 is a protein that in humans is encoded by the SNX18 gene.

<span class="mw-page-title-main">Sorting nexin</span>

Sorting nexins are a large group of proteins that are localized in the cytoplasm and have the potential for membrane association either through their lipid-binding PX domain or through protein–protein interactions with membrane-associated protein complexes Some members of this family have been shown to facilitate protein sorting.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000130340 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000002365 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. 1 2 3 Howard L; Nelson KK; Maciewicz RA; Blobel CP (Dec 1999). "Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1". J Biol Chem. 274 (44): 31693–9. doi: 10.1074/jbc.274.44.31693 . PMID   10531379.
  6. Yarar D; Waterman-Storer CM; Schmid SL (Jul 2007). "SNX9 couples actin assembly to phosphoinositide signals and is required for membrane remodeling during endocytosis". Dev Cell. 13 (1): 43–56. doi: 10.1016/j.devcel.2007.04.014 . PMID   17609109.
  7. 1 2 "Entrez Gene: SNX9 sorting nexin 9".
  8. Lundmark, Richard; Carlsson Sven R (Nov 2003). "Sorting nexin 9 participates in clathrin-mediated endocytosis through interactions with the core components". J. Biol. Chem. United States. 278 (47): 46772–81. doi: 10.1074/jbc.M307334200 . ISSN   0021-9258. PMID   12952949.

Further reading