Sorting nexin-9 is a protein that in humans is encoded by the SNX9 gene. [5] [6] [7]
This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but does contain an SH3 domain near its N-terminus. This protein interacts with the cytoplasmic domains of the precursor but not the processed forms of a disintegrin and metalloprotease domain 9 and 15. This protein binds the beta-appendage domain of adaptor protein 2 and may function to assist adaptor protein 2 in its role at the plasma membrane. This protein interacts with activated Cdc42-associated kinase-2 to regulate the degradation of epidermal growth factor receptor protein. [7]
SNX9 has been shown to interact with ADAM9, [5] DNM2 [8] and ADAM15. [5]
Sorting nexin-1 is a protein that in humans is encoded by the SNX1 gene. The protein encoded by this gene is a sorting nexin. SNX1 is a component of the retromer complex.
Myc box-dependent-interacting protein 1, also known as Bridging Integrator-1 and Amphiphysin-2 is a protein that in humans is encoded by the BIN1 gene.
Epidermal growth factor receptor substrate 15 is a protein that in humans is encoded by the EPS15 gene.
Dynamin-2 is a protein that in humans is encoded by the DNM2 gene.
AP-2 complex subunit alpha-1 is a protein that in humans is encoded by the AP2A1 gene.
Clathrin heavy chain 1 is a protein that in humans is encoded by the CLTC gene.
Dynamin-1 is a protein that in humans is encoded by the DNM1 gene.
AP-1 complex subunit beta-1 is a protein that in humans is encoded by the AP1B1 gene.
Endophilin-A1 is a protein that in humans is encoded by the SH3GL2 gene.
Formin-binding protein 1 is a protein that in humans is encoded by the FNBP1 gene.
Low-density lipoprotein receptor adapter protein 1 is a protein that in humans is encoded by the LDLRAP1 gene.
AP-1 complex subunit gamma-like 2 is a protein that in humans is encoded by the AP1G2 gene.
Sorting nexin-17 is a protein that in humans is encoded by the SNX17 gene.
Epsin-1 is a protein that in humans is encoded by the EPN1 gene.
TC10/CDC42 GTPase-activating protein is an enzyme that in humans is encoded by the SNX26 gene.
Sorting nexin-3 is a protein that in humans is encoded by the SNX3 gene.
Sorting nexin-15 is a protein that in humans is encoded by the SNX15 gene.
Sorting nexin-4 is a protein that in humans is encoded by the SNX4 gene.
Sorting nexin-18 is a protein that in humans is encoded by the SNX18 gene.
Sorting nexins are a large group of proteins that are localized in the cytoplasm and have the potential for membrane association either through their lipid-binding PX domain or through protein–protein interactions with membrane-associated protein complexes Some members of this family have been shown to facilitate protein sorting.