SNX15

SNX15
Identifiers
Aliases	SNX15 , HSAF001435, sorting nexin 15
External IDs	OMIM: 605964 MGI: 1916274 HomoloGene: 12294 GeneCards: SNX15
Gene location (Mouse) Chr. Chromosome 19 (mouse) [1] Band 19|19 A Start 6,169,429 bp [1] End 6,178,334 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bone marrow cells prefrontal cortex cerebellar hemisphere monocyte skeletal muscle tissue gastrocnemius muscle popliteal artery right coronary artery Brodmann area 9 amygdala Top expressed in blood superior frontal gyrus islet of Langerhans yolk sac lip gastric mucosa Epithelium of stomach external carotid artery spermatocyte mucous cell of stomach More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding phosphatidylinositol binding lipid binding Cellular component nucleolus cytoplasmic vesicle membrane membrane cytoplasmic vesicle cytoplasm cytosol Biological process protein transport signal transduction intracellular protein transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29907 69024 Ensembl n/a ENSMUSG00000024787 UniProt Q9NRS6 Q91WE1 RefSeq (mRNA) NM_147777 NM_013306 NM_026912 RefSeq (protein) NP_037438 NP_680086 NP_081188 Location (UCSC) n/a Chr 19: 6.17 – 6.18 Mb PubMed search [2] [3]
Wikidata
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Sorting nexin-15 is a protein that in humans is encoded by the SNX15 gene. ^{[4] [5]}

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. Overexpression of this gene results in a decrease in the processing of insulin and hepatocyte growth factor receptors to their mature subunits. This decrease is caused by the mislocalization of furin, the endoprotease responsible for cleavage of insulin and hepatocyte growth factor receptors. This protein is involved in endosomal trafficking from the plasma membranee to recycling endosomes or the trans-Golgi network. This gene encodes two transcript variants encoding distinct isoforms. ^[5]

References

1. GRCm38: Ensembl release 89: ENSMUSG00000024787 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Barr VA, Phillips SA, Taylor SI, Haft CR (Mar 2001). "Overexpression of a novel sorting nexin, SNX15, affects endosome morphology and protein trafficking". Traffic. 1 (11): 904–16. doi:10.1034/j.1600-0854.2000.011109.x. PMID   11208079. S2CID   31092568.
5. "Entrez Gene: SNX15 sorting nexin 15".

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Guru SC, Agarwal SK, Manickam P, et al. (1997). "A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus". Genome Res. 7 (7): 725–35. doi:10.1101/gr.7.7.725. PMC   310681 . PMID   9253601.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Phillips SA, Barr VA, Haft DH, et al. (2001). "Identification and characterization of SNX15, a novel sorting nexin involved in protein trafficking". J. Biol. Chem. 276 (7): 5074–84. doi: 10.1074/jbc.M004671200 . PMID   11085978.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.