Sepiapterin reductase (L-threo-7,8-dihydrobiopterin forming)

Sepiapterin reductase (L-threo-7,8-dihydrobiopterin forming)
Identifiers
EC no.	1.1.1.325
CAS no.	9059-48-7
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

Sepiapterin reductase (L-threo-7,8-dihydrobiopterin forming) (EC 1.1.1.325) is an enzyme with systematic name L-threo-7,8-dihydrobiopterin:NADP⁺ oxidoreductase. ^{[1] [2]} This enzyme catalyses the following chemical reaction

(1) L-threo-7,8-dihydrobiopterin + NADP⁺${\displaystyle \rightleftharpoons }$ sepiapterin + NADPH + H⁺

(2) L-threo-tetrahydrobiopterin + 2 NADP⁺${\displaystyle \rightleftharpoons }$ 6-pyruvoyl-5,6,7,8-tetrahydropterin + 2 NADPH + 2 H⁺

This bacterial ( Chlorobium tepidum ) enzyme catalyses the final step in the de novo synthesis of tetrahydrobiopterin from GTP.

References

1. Cho SH, Na JU, Youn H, Hwang CS, Lee CH, Kang SO (June 1999). "Sepiapterin reductase producing L-threo-dihydrobiopterin from Chlorobium tepidum". The Biochemical Journal. 340 ( Pt 2) (2): 497–503. doi:10.1042/0264-6021:3400497. PMC   1220277 . PMID   10333495.
2. Supangat S, Choi YK, Park YS, Son D, Han CD, Lee KH (February 2005). "Expression, purification, crystallization and preliminary X-ray analysis of sepiapterin reductase from Chlorobium tepidum". Acta Crystallographica Section F. 61 (Pt 2): 202–4. doi:10.1107/S174430910403444X. PMC   1952253 . PMID   16510994.

External links

• Sepiapterin+reductase+(L-threo-7,8-dihydrobiopterin+forming) at the U.S. National Library of Medicine Medical Subject Headings (MeSH)