(R)-pantolactone dehydrogenase (flavin)

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(R)-pantolactone dehydrogenase (flavin)
Identifiers
EC no. 1.1.99.27
CAS no. 140879-14-7
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / QuickGO
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PMC articles
PubMed articles
NCBI proteins

In enzymology, (R)-pantolactone dehydrogenase (flavin) (EC 1.1.99.27) is an enzyme that catalyzes the chemical reaction

 
 
 
(R)-pantolactone dehydrogenase (flavin)
 
 
 
+ reduced acceptor
 

The two substrates of this enzyme are (R)-pantolactone and an electron acceptor. Its products are 2-dehydropantolactone and the corresponding reduced acceptor. [1] [2]

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with other acceptors. The systematic name of this enzyme class is (R)-pantolactone:acceptor oxidoreductase (flavin-containing). Other names in common use include 2-dehydropantolactone reductase (flavin), 2-dehydropantoyl-lactone reductase (flavin), and (R)-pantoyllactone dehydrogenase (flavin).

References

  1. Enzyme 1.1.99.27 at KEGG Pathway Database.
  2. Kataoka M, Shimizu S, Yamada H (1992). "Purification and characterization of a novel FMN-dependent enzyme Membrane-bound L-(+)-pantoyl lactone dehydrogenase from Nocardia asteroides". Eur. J. Biochem. 204 (2): 799–806. doi: 10.1111/j.1432-1033.1992.tb16698.x . PMID   1541293.